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Presenter Name(s)	Mentor and Co‑Author Name(s)	Abstract Title	Session Time / Location	Poster Number / Oral Presentation Time
Downs-Paprocki, Kyla Heitman, June	Lowell, Randy	Can you spot a serial killer? View Full Text Abstract Text Imagine that you’re asked to identify the perpetrator of a violent crime and are presented with suspects, some you’re told have mental disorders. Would that push you towards those suspects? Based on the literature related to attitudes about mental illness and violence, this may be the case (e.g., Angermeyer & Matschinger, 1996; Link et al., 1999; Swanson et al, 2008; Van Dorn et al., 2012). Many studies in the literature that look at these connections between mental illness, and attitudes about mental illness, and violence reflect explicit attitudes on this topic. The current study brings awareness to bias at a physiological level connected to conscious awareness of what people think they use to make judgments. We connect those attitudes to the extreme violence by serial killers. That is, do people associate mental illness with serial killers, and if so, how strong is that association and how aware are people of that association for themselves? Specifically, we examine how biases, such as those related to stereotypes surrounding mental illness and violence affect assumptions about characteristics of serial killers. This includes examination of the roles of implicit (i.e., eye movement behavior) and explicit (i.e., survey responses) attitudes related to mental illness and other demographic characteristics on judgments about serial killers. Participants completed pre- and post-eyetracking questionnaires. For the eyetracking portion, participants read a series of 36 trial profiles in random order on the screen (24 serial killer, 12 controls). Each profile consisted of 10 characteristics about a real person, and based on those characteristics, the participant indicated if they believed that the profile was a serial killer (“yes”) or not (“no”). Discrepancies between the profile information that people implicitly attended to (i.e., eye movement behavior) and their explicit responses regarding which information they believed they relied on will be discussed.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Rechsteiner, Jenna	Boggs, Carol Duverglas, Laurent	Morphological Variation in Euphydryas gillettii Butterflies Across Time and Space View Full Text Abstract Text Examining variation in dispersal capability is essential to understanding the effects of global environmental change on the ability of organisms to colonize new habitats. Dispersal capability depends on wing morphology. I examined the disparity in dispersal potential between and within two populations of differing age of Euphydryas gillettii in the Colorado Rocky Mountains. To examine morphological differences as a function of space, approximately 70 butterflies were photographed from two sites, which differ in their habitat characteristics. Wing and body size measurements were taken from the photographs, and the butterflies were weighed to the nearest 0.1 mg. These measurements were used to determine wing loading and aspect ratio. To determine how E. gillettii morphologies have changed across time, wing measurements were compared to measurements derived from photos in one of the sites in 2011, 2013, 2017, 2019, and 2024. Initial data analysis shows significant differences in wing loading as a function of sex and site and differences in aspect ratio as a function of site, sex, and year. Our results indicate that dispersal capability is changing across both space and time.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Staniszewski, Adrianna	Wirth, Michael Dawson, Robin Abshire, Demetrius	Comparing Academic Stress and Perceived Stress Among Nursing Students of Various Education Levels View Full Text Abstract Text Background: The nursing undergraduate major tends to be one of the most stressful undergraduate degrees. Evidence shows that stress does not only affect undergraduate nursing students during their education but carries through to their professional lives. Less research exists about graduate nursing student stress. Purpose: Determine if nursing students in post- vs pre-licensure programs experience the same levels of academic/perceived stress. Methods: This study was a comparative cross-sectional design. The pre-licensure cohort consisted of Lower Division Undergraduates, Upper Division Undergraduates, and Master’s Entry to Practice Nursing students. The post-licensure cohort consisted of Doctor of Philosophy in Nursing, Doctor of Nursing Practice, and Master of Nursing Practice students. Data were collected using virtual surveys on RedCap software that measured perceived and academic stress using the Perceived Stress Scale (PSS-10) and Academic Stress Scale. Confounding variables were collected using the Resilience Scale for Adults (RSA), Center for Epidemiologic Studies Depression (CESD) scale, International Physical Activity Questionnaire (IPAQ), Eating at America’s Table Quick Food Scan, and Pittsburgh Sleep Quality Index (PSQI). Data was analyzed through correlation testing and two-sample t-testing. Results: Within pre-licensure, there was a strong positive correlation between academic stress and perceived stress (⍴=0.67). There was no significant correlation between academic stress and perceived stress in post-licensure students (⍴=0.37). Within post-licensure, there was a strong negative correlation between CESD score and the ‘social resources’ subscore of the RSA (⍴=0.62). Post-licensure students had a significantly higher PSS-10 score of 21.94 versus pre-licensure students’ score of 19.57 (p=0.008). Post-licensure students had a significantly higher ‘personal strength/perception of self’ resilience scale subscore of 22.58 versus pre-licensure's subscore of 19.56 (p=<0.01). Conclusions/Implications: This area of research would greatly benefit from a study focusing on each individual education level, as well as qualitative interviews or focus groups to provide personalized insight.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Tiseth, Olivia	Vaughn, Paige	Evaluating Procedural Justice Attitudes and Behaviors Using Body-Worn Cameras View Full Text Abstract Text Procedural justice training has shown to be effective at changing police attitudes towards community members, but there’s still little proof that this training changes actual behaviors in the field. This project aims to assess the impact of procedural justice training on the behaviors exhibited by police officers in Yonkers, NY, using body-worn camera (BWC) footage. In particular, we will examine officer interactions with civilians in various situations, including in responding to frequent calls for service, such as disorderly persons, verbal disputes, traffic violations, and suspicious persons, and in proactively engaging with citizens via directed patrol. This will allow us to determine the behavioral effects of procedural justice training as well as uncover specific areas for improvement. In the process, we have developed a novel method for quantifying procedural justice behaviors in BWC footage and thereby allow for more meaningful accountability using this widespread – though as yet unproven – technology. Our goal is to measure the prevalence of each “pillar” of procedural justice – voice, neutrality, respect, benevolence – in BWC footage. This model allows us to conduct a statistically robust study on the real-world impact of procedural justice training. Moreover, such a model could allow police departments and scholars to draw insights from the vast amounts of BWC video that is currently underutilized or disregarded entirely.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Forrester, Ella	Guimaraes, Edena Torres, Myriam	Knowledgeable Births: Advancing Informed Consent in Maternal Healthcare View Full Text Abstract Text Background: Informed consent is both a legal requirement and an ethical cornerstone of healthcare, ensuring that patients understand and voluntarily agree to medical treatments. However, evidence suggests that the informed consent process is often inadequately implemented in maternal healthcare settings, particularly during childbirth. While giving birth, women retain full decision-making capacity but are not consistently provided with sufficient information or support to exercise this right. Contributing factors include ineffective patient–provider communication, limited health literacy, and insufficient access to culturally responsive educational resources. Methods: This study aimed to address gaps in accessible prenatal education by developing an online resource platform, Know Your Birth, designed for pregnant individuals in the United States aged 18 years or older. The platform delivered clear, culturally sensitive, and evidence-based information regarding prenatal care, common medical interventions, and patient rights during childbirth. Two cross-sectional surveys were administered to evaluate user engagement and perceived effectiveness of the platform in improving knowledge and awareness. Results: Survey results demonstrated that participants reported increased understanding of routine prenatal visits, common obstetric procedures, and their legal rights during labor and delivery, including the right to provide or refuse informed consent. Users also indicated that the platform was accessible, easy to navigate, and helpful in preparing them for discussions with healthcare providers. Conclusion: The findings suggest that accessible digital educational interventions may improve comprehension of informed consent and patient rights among reproductive-age populations. Digital tools such as Know Your Birth may serve as scalable strategies to promote patient autonomy and health literacy in maternal healthcare. Future research should assess whether such interventions influence clinical decision-making behaviors and maternal health outcomes. Keywords: Patient autonomy; reproductive health; childbirth; informed consent; health literacy; digital health intervention; maternal health communication	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
John, Sarah	Tasseva-Kurktchieva, Mila Fahey, Danielle Rubina, Angelina Ausheva, Ekaterina McMahon, Scout	Russian-English Bilingual Processing of Cognates in Written and Oral Modes View Full Text Abstract Text The present research investigates (i) the effect of the phonological and orthographic overlap on bilingual processing in languages with partially overlapping scripts (Russian and English), and (ii) whether language proficiency affects the interaction between orthography and phonology. We employed a bilingual cognate similarity rating study in the spoken and written modes. Caramazza & Brones (1979), Dijkstra et al. (1999), Sánchez-Casas et al. (1992), among others, have shown that cognates are processed faster than non-cognates across tasks, modalities and bilingual populations. However, most research on cognate facilitation used language pairs with overlapping scripts (Hoshino & Kroll, 2008) and employed almost exclusively the written mode of language presentation (Fahey, 2021), disregarding the potential influence of (a) partially overlapping scripts and (b) mode of presentation on the activation of the orthographic and phonological structures. 24 participants (4 native speakers of English and 20 heritage speakers of Russian) completed a perceived similarity rating study in two blocks: auditory and written. Each block presented 120 English-Russian and Russian-English cognate pairs in randomized, counterbalanced order. Participants indicated similarity on a 7-point Likert scale. Normalized Levenshtein orthographic and phonological distances were used as an independent measure of cognate similarity. We used the AIC values (Vrieze, 2012) in a forward stepwise ordinal logistic regression to determine the best fit model . Results suggested that orthographic and phonological distances both contributed to the perceived similarity of cognates, with the self-reported native language and country of origin also having an effect while mode of presentation and proficiencies had no significant effect on the perceived similarity. In agreement with Fahey (2021), we observe that in auditory presentation, orthographic overlap continues to have an influence on bilingual processing of cognates.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Stamper, Natalie	Bulusu, Subrahmanyam	Salinity Dynamics During Marine Heatwaves in the Northwest Atlantic: The Role of Gulf Stream Eddies View Full Text Abstract Text The frequency and intensity of marine heatwaves (MHWs) have increased globally, with pronounced expression in western boundary current systems such as the Gulf Stream (GS), where circulation variability regulates upper-ocean stratification and heat storage. Here, we investigate salinity dynamics during MHWs in the Northwest Atlantic, focusing on their co-evolution with surface and subsurface temperature. Satellite-derived sea surface temperature and salinity observations are combined with high-resolution ocean reanalysis to characterize both horizontal patterns and vertical structure during recent active MHW years. A consistent threshold-based framework is applied to identify anomalous temperature and salinity conditions and to examine their coupling. Using a largest-contour eddy tracking algorithm applied to satellite sea surface height and reanalysis fields, we quantify relationships between GS eddy characteristics, salinity anomalies, and MHW properties. Results show that surface freshening enhances upper-ocean stratification, suppresses vertical mixing, and promotes longer-lived, surface-intensified MHWs. Conversely, saline intrusions linked to GS advection and warm-core rings weaken stratification, enhance vertical exchange, and favor deep-reaching MHWs with subsurface expression. Extreme shelf freshening during 2023 coincided with widespread and persistent MHW conditions, underscoring salinity as a key dynamical control on MHW evolution. Additionally, MHW surface coverage and intensity exhibit an inverse relationship that aligns with the relative occurrence of events within cool-core versus warm-core rings. These findings highlight the central role of salinity variability and GS eddy activity in modulating the structure, intensity, and persistence of MHWs in the Northwest Atlantic.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Yu, Tiffany	Karakchi, Rasha	AutoSlim: Intelligent Automata Graph Optimization for Efficient Acceleration View Full Text Abstract Text Modern high-performance computing increasingly relies on sophisticated graph-based models to represent and manipulate symbolic data. From bioinformatics and cyber security to inference of the AI model and text analytics, these applications often use directed graphs to capture complex dependencies and transitions between states. However, as data sets and patterns grow in complexity and size, graph representations - composed of nodes and edges - also expand dramatically, resulting in excessive memory usage, power consumption, routing congestion, and inefficiencies in hardware acceleration platforms such as Field-Programmable Gate Arrays (FPGAs). These graphs often contain redundancies, such as rarely activated nodes, unnecessary connections, or expensive computation paths that contribute little to the final output, yet significantly bloat the hardware footprint. To address this challenge, this paper presents AutoSlim, an intelligent automata graph optimization framework that leverages AI-based analysis to reduce the complexity of large-scale pattern matching graphs while maintaining their core functionality. At the heart of AutoSlim is a toolchain developed to generate a synthesizable benchmark suite of graph datasets with detailed annotations. These annotations go beyond standard state transition labels to include per-edge scoring metrics that indicate the frequency, likelihood, or computational cost of traversing a specific edge during matching operations. This scoring information is extracted from prior runs or static graph analysis and is instrumental in identifying nodes and edges with minimal contribution to system functionality. The proposed framework then applies a supervised machine learning model - specifically a Random Forest classifier - trained to identify graph components with low impact. The classifier distinguishes redundant or infrequently used edges and nodes based on various features such as transition frequency, edge weights, and connectivity patterns. Using this predictive capability, AutoSlim prunes the graph structure, removing edges and nodes that are unlikely to impact overall match accuracy or output correctness.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Ganesh Babu, Shyam	Pena, Marj Mao, Qiuyi Byrd Fort, Valerie	Early Life Exposure to Antibiotics and Risk for Early-Onset Colorectal Cancer View Full Text Abstract Text The incidence of early-onset colorectal cancer (EOCRC), which is colorectal cancer in patients fifty years of age, has steadily increased since the 1980s, rising from 6% to 11% over two decades, and predicted to increase by 140% in 2032. It is now the leading cause of cancer related deaths in patients under 50 years of age, and the underlying causes are poorly understood. In this study I hypothesized that early life exposure to commonly prescribed pediatric antibiotics can disrupt the gut microbiota, causing dysbiosis that leads to chronic inflammation thereby increasing the risk for developing EOCRC. We used a mouse model of EOCRC to determine the effect of multiple exposures to antibiotics on tumor development and found that certain classes of antibiotics promote the growth of pathogenic bacteria that cause inflammation and promote increased tumor burden in the distal rectum upon exposure to azoxymethane, a carcinogen. We then examine the impact of probiotics or fecal microbiome transplantation to rebuild the gut microbiota after antibiotic exposure on mitigating the risk of developing EOCRC. These studies will assess the effects of antibiotics early in life of gut microbiome composition and their impact on risk of developing EOCRC later in life. The results can lead to development of simple yet novel strategies to identify individuals who are at risk of developing EOCRC and minimize long-term antibiotic-associated cancer risk in pediatric populations.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Marshall, David	Wright, Pamela	Evaluation of Inter-method Reliability between Online and In-person Fitness Assessments among Physically Inactive Adults View Full Text Abstract Text Background: Online assessments are common. However, scarce research compares the accuracy of online assessments to in-person assessments. Purpose: The purpose of this study was to evaluate the reliability of an online versus in-person fitness assessment . Methods: Participants (N=20) were recruited using flyers. Participants completed an online fitness assessment followed by an in-person fitness assessment 2-10 days later. Reliability was evaluated using intraclass correlation coefficients and Bland-Altman plots. Results: Participants were 30.8(±20.2) years, mostly female (76.5%), and diverse in race/ethnicity with a body mass index of 23.4kg/m2 (±3.8). Statistically significant intraclass correlation coefficients were excellent for waist circumference (0.93), hip circumference (0.94), and push-up test (0.94) and good for static squat test (0.89) and curl up test (0.76). Conclusion: The online fitness assessment revealed high reliability when compared to an in-person fitness assessment.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Spires, Savanna	Hatchett, Andrew	The Effect of Upper and Lower Extremity Power on Countermovement Jump Performance With Arm Swing and Without View Full Text Abstract Text The countermovement jump (CMJ) is a common measure of lower-body power and neuromuscular performance. Incorporating an arm swing (AS) enhances CMJ outcomes, yet the contributions of anthropometrics, body composition (BC), and muscular power to performance are not fully understood in recreationally active adults. This study examined these factors in CMJ trials with and without AS. Thirty adults (15 males, 15 females; 18–25 years) performed CMJs on a force plate. Upper-body power was assessed via an 8 kg medicine ball throw, and lower-body power using a maximal cycling-based power test. Three-dimensional body scanning captured anthropometric data. Descriptive statistics, Pearson correlations, and hierarchical multiple regressions were conducted for the total sample and by sex. Jump height and peak power were significantly higher with AS than without (p < .001). Strong positive correlations were observed among jump- and power-related variables (r = .73–.92). Body fat percentage showed moderate-to-strong negative associations with relative peak power, particularly in females. Regression analyses revealed that BC accounted for the largest proportion of variance in AS peak power, whereas upper-body power did not provide additional predictive value beyond anthropometrics and BC. These findings indicate that CMJ performance is primarily influenced by lower-body mechanical capacity and BC, with adiposity consistently reducing relative power output. The results underscore the importance of BC in explosive performance training and support the use of AS-restricted jumps to isolate lower-body power during performance assessments.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Stahle-Smith, Rye	Karakchi, Rasha	Real-time ML-based Defense Against Malicious Payload in Reconfigurable Embedded Systems View Full Text Abstract Text Field-programmable gate arrays (FPGAs) in reconfigurable systems face escalating security threats from malicious bitstreams capable of causing denial-of-service, data leakage, or covert operations. Traditional detection methods often require source code or netlists, limiting their applicability for real-time protection. We present a supervised machine learning approach that directly analyzes FPGA bitstreams at the binary level, enabling rapid detection without design-level access. Using byte frequency analysis, truncated singular value decomposition (TSVD), and SMOTE balancing, we developed and evaluated multiple classifiers on a dataset of 122 benign and malicious configurations for the Xilinx PYNQ-Z1 board. Random Forest achieved a macro F1-score of 0.97, validating the method’s effectiveness for resource-constrained devices. The final model was deployed on PYNQ for integrated, on-device analysis. During the poster session, we will outline our detection pipeline, dataset preparation process, and performance results, emphasizing the novelty of binary-level analysis and its implications for real-time Trojan detection in embedded systems.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Griffin, Molly	Meyer, Chase Spence, Gina	The Digital Divide: Voter Perceptions in the Age of Social Media View Full Text Abstract Text This thesis examines how social media shapes voter perceptions of candidate ideology and economic issues, and how these perceptions influence electoral decision-making. As digital platforms increasingly serve as primary sources of political information, exposure to negative content and patterns such as doom-scrolling can affect voters’ understanding of political realities. The study explores how social media reinforces preexisting beliefs, amplifies stereotypes, and creates echo chambers that shape both perceptions and choices in elections. Using survey data from US senators collected from the 2020 and 2022 election cycles, the research investigates the mechanisms by which digital media influences voter behavior. It also considers moderating factors, such as age, education, and demographics, that shape how individuals interpret and respond to online political content. The findings aim to provide insights into the intersection of technology, information processing, and electoral behavior, highlighting the broader implications of digital media on democratic participation. By illuminating how social media can subtly influence voter cognition and decision-making, this research contributes to a deeper understanding of political communication in the digital age and informs strategies to promote informed and equitable civic engagement.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Hampton, Emma	Kim, Jung-Hwan	How Social Media Influencers Persuade Consumers: Promotional Tactics in Consumer Behavior View Full Text Abstract Text Social media influencers (SMIs), defined as experts or social connectors who influence others’ attitudes toward products and brands (Fakhreddin and Foroudi, 2021), play a significant role in product promotion. Currently, about 5.24 billion people worldwide use social media, representing approximately 96% of internet users (Statista, 2025). Many consumers now visit influencers’ pages to seek product information and build connections (Hassan et al., 2021). As reliance on SMIs grows, many retailers collaborate with them to promote products (Kenan, 2024). However, a notable drawback is that influencers often prioritize revenue generation without fully understanding the products or brands they promote (Duffek et al., 2025). Retailers often depend on influencers without critically evaluating the promotional tactics being used. These practices can result in compulsive buying behaviors and distorted brand perceptions caused by misleading or unethical promotions (Roach, 2024). As digital natives who have never lived without smartphones, Gen Z consumers frequently rely on social media for product information and often base purchase decisions on SMIs’ recommendations (Schaefer, 2025). TikTok is reported to be their preferred platform for product discovery, followed by Instagram (eMarketer, 2025). Given Gen Z’s reliance on social media for product reviews, they are particularly vulnerable to being swayed by SMIs,sometimes resulting in compulsive purchasing behaviors. Therefore, this study seeks to examine the promotional tactics SMIs use to persuade Gen Z consumers to purchase products and to explore how they perceive these tactics in relation to their decision-making processes.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Eichler, Emerson Grieco, Alex	Wilson-King, Dawn Liles, Olivia Leahy, Grace Leech, Connor St. John, Anna Claire	An Overview and Baseline Data of the Linking Exercise for Advancing Daily Stress (LEADS) Management and Resilience in African American Families Trial View Full Text Abstract Text Chronic stressors place African American (AA) adolescents at greater risk for developing chronic diseases. Resilience-based interventions that empower youth to cope with chronic stressors have shown improvements across a broad range of outcomes, however, no previous study has evaluated a family-based resilience plus positive parenting intervention on improving physical activity (PA) in AA families. The purpose of the presentation is to describe the design and methodology of the Linking Exercise for Advancing Daily Stress (LEADS) Management and Resilience NIH trial, for evaluating the efficacy of a family-based intervention to address chronic stressors and promote behavioral skills for increasing PA in overweight AA adolescents; and to provide an overview of the study sample and baseline measures. The LEADS trial uses a randomized group cohort design and involves 330 AA adolescents with a BMI percentile > 70%. The trial tests the efficacy of a 10-week online family-based intervention (vs. health education) and draws from Stress and Coping, Family Systems, and Social Cognitive Theories to integrate components that build coping skills for engaging in PA. A total of 76 participants have enrolled, and, on average, adolescents are 12.9 (SD=1.6) years old with a body mass index (BMI) percentile of 97.9 (SD=3.1), with 50% female participants. On average, caregivers are 42.3 (SD=8.4) years old with a BMI (kg/m2) of 40.8 (SD=11.0), and 99% are female. 41% of our caregivers are married with 72% have had some high school or college education. The primary outcome of the trial is change in minutes of moderate to vigorous PA (MVPA) at post-intervention and 6-month follow-up among adolescents. Secondary outcomes include changes in MVPA in caregivers, as well as changes in light PA, diet, family mealtime, BMI, waist circumference, and blood pressure in adolescents and caregivers. This trial will inform best practices for promoting health among AA families.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
McGuff, Madeline Eagles, Amani	Wilson, Dawn Ferrara, Marisa Thompson, Khalon Gantt, Miriam White, Taylor	Associations of Perceived Stress, Adaptive, and Maladaptive Coping on Quality of Family Mealtime in African American Adolescents and their Parents View Full Text Abstract Text African Americans (AA) have the high rates of chronic stress exposure (e.g., neighborhood disorder, financial strain). Furthermore, stress has been associated with less nutritious food intake, as individuals who report higher perceived stress and are more likely to consume high-caloric, energy dense foods. Few studies have, however, focused on understanding how stress and coping relate to quality of family mealtime in AA adolescents. The current study investigated how perceived stress, adaptive coping (social support) and maladaptive coping (behavioral disengagement), were associated with quality of family mealtime in AA adolescents and their parents. AA dyads (adolescent, parent) participated (N=49) in the study. The mean age of adolescents was 13.8 years (SD=1.9), and the mean age of parents was 45.7 years (SD=10.0). Validated self-report measures assessed perceived stress and coping (behavioral disengagement, emotional support, and tangible support) as well as quality of family mealtime. Results showed a significant negative association between parent stress and quality of family mealtime, (r = -0.41, p<0.01), indicating that as perceived stress decreased family mealtime quality increased. For adolescents, there was a positive correlation between maladaptive coping (behavioral disengagement) and perceived stress (r = 0.46, p<0.01) indicating that as maladaptive coping increased, perceived stressed also increased. Only adaptive coping strategies (emotional and tangible support) were significantly associated with family mealtime. Specifically, there was positive association between perceived emotional support and quality of family mealtime in adolescents, (r=0.37, p<0.05), indicating that as perceived emotional support increased perceptions of quality of mealtime increased. A significant positive association between perceived tangible support and quality of family mealtime in adolescents, (r=0.40, p<0.05) also demonstrated that as perceived tangible support increased perceptions of quality of family mealtime also increased. These results provide new insights into understanding the role of stress and adaptive coping on dietary outcomes in AA adolescents and their parents.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Woytowitz, Sophia	Childs, Matthew	Altitude and Empire: Environmental Constraint and Human Adaptation in Andean Peru View Full Text Abstract Text This project argues that chronic high-altitude hypoxia fundamentally structured political organization, labor systems, and inequality in Andean Peru, shaping both imperial success under Inca rule and conditions under Spanish colonial expansion. Rather than treating altitude as passive geography, I analyze reduced atmospheric oxygen as a measurable physiological constraint using hemoglobin transport as an interpretive framework. At Andean elevations, decreased partial pressure of oxygen lowers hemoglobin saturation and limits tissue oxygen delivery, placing ceilings on endurance and sustained physical labor. Although acclimatization responses such as increased 2,3-bisphosphoglycerate levels and rightward shifts of the hemoglobin–oxygen dissociation curve improve oxygen unloading, they do not eliminate the metabolic costs of chronic hypoxia. Inca political systems implicitly aligned governance with these biological realities. Agricultural terraces stabilized food production in marginal terrain, vertical ecological exchange distributed resources across elevations, ayllu-based communal labor regulated work demands, and quipu recordkeeping coordinated redistribution to prevent overexertion in hypoxic environments. Together, these institutions moderated cumulative physiological strain and enabled dense highland populations to persist. In contrast, Spanish colonial expansion intensified labor extraction through expanded mita drafts while dismantling Indigenous administrative systems attuned to altitude-specific constraints. By disregarding the physiological limits imposed by hemoglobin-based oxygen transport, colonial authorities amplified fatigue, illness, and inequality between highland laborers and lowland centers such as Lima. Overall, this study demonstrates that oxygen transport functioned as a structural determinant of imperial stability. Political systems in the Andes succeeded when they operated within biological limits imposed by altitude and destabilized when they exceeded them.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Mahoney, Audrey	McQuail, Joseph Stone, Leah Vento, Peter	Development and Validation of a Translational Dual-Task Paradigm for Assessing Executive Function in Rodent Models of Aging and Alzheimer’s Disease View Full Text Abstract Text Aging is the strongest risk factor for Alzheimer’s disease (AD), yet executive control processes such as cognitive flexibility and task switching are also vulnerable to normative aging. Distinguishing age-related executive decline from early AD-related dysfunction requires paradigms that isolate specific control mechanisms rather than global performance deficits. We developed and validated a rodent dual-task paradigm designed to quantify executive control demands through switching and mixing costs. Male and female TgF344-AD rats and wild-type (WT) littermate controls were tested alongside young (~6 months) and aged (~26 months) F344 rats. Using operant chambers, rats were trained to alternate between matching and non-matching rules. Switching costs were defined as performance differences between repeat and switch trials within mixed blocks and mixing costs as differences between single-task and mixed-task blocks. Accuracy and latency were measured to dissociate executive-specific impairments from generalized slowing. Accuracy declined as executive demand increased, with non-matching and mixed-block conditions producing greater costs than single-task conditions. Switching costs were significantly greater than mixing costs (p < 0.0001), demonstrating robust sensitivity to rule-switching demands. Latency was unaffected, indicating that performance costs reflected executive accuracy impairments rather than motor slowing. Although aged rats exhibited reduced overall accuracy relative to young rats, the magnitude of switching and mixing costs did not differ by age. Importantly, Tg rats did not differ from WT controls in switching or mixing costs, suggesting preserved executive flexibility at this stage of AD pathology. These findings demonstrate that the paradigm reliably engages executive control mechanisms and dissociates executive-specific accuracy costs from generalized cognitive load. This framework provides a mechanistically sensitive platform for longitudinal studies investigating the emergence of executive dysfunction and its translational relevance to early cognitive decline in AD.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Calhoun, Elizabeth	Meyer-Gutbrod, Erin Walsh, Ryan	Understanding migratory behavior of the Pacific Coast Feeding Group gray whales through barnacle morphology and body condition View Full Text Abstract Text The Pacific Coast Feeding Group (PCFG) is a subset of approximately 213 individuals from the Eastern North Pacific (ENP) gray whale population. Both the ENP and the PCFG have declined in abundance. PCFG gray whales migrate annually from summer foraging grounds of northern California to northern British Columbia, to winter breeding grounds in the lagoons of Baja California, Mexico. However, recent evidence suggests that some PCFG whales have not migrated south each breeding season, biasing the annual abundance estimates derived from shore-based observations of migrating whales in Point Reyes, California. In the breeding lagoons and on the southern range of the migration corridor, barnacles, Cryptolepas rhachianecti, rapidly recruit to gray whales. These barnacles have characteristic morphologies of each growth stage post-settlement which can be leveraged to determine gray whale migratory behavior. We assumed that an absence of young barnacles on an individual observed on the northern corridor was indicative of that whale not fully migrating south during the previous breeding season. The Makah Tribe provided photos spanning from 2014 to 2020 of PCFG whales observed in northwest Washington. We delineated 26 distinct anatomical regions on individual gray whales to assess the overall visibility (i.e., effort), barnacle presence, and barnacle life stage in each defined body region for every month that a whale was observed. Results will be compared to the body condition of individuals to evaluate if an underlying health factor is correlated with migration decisions. We hypothesized that a whale without juvenile barnacles would have insufficient energy stores needed to complete the migration, and therefore, remain in the north, preventing new barnacle recruitment. The results from this study will help inform whether this non-invasive method of evaluating migratory behavior can be used to aid abundance estimates, while attempting to elucidate factors that drive migration decision-making.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Yigamawano, Francesco	Shazly, Tarek Spinale, Francis	Myocardial stiffness properties are improved in heart failure with preserved ejection fraction (HFpEF) in pigs by a regular exercise regimen View Full Text Abstract Text Left ventricular (LV) pressure overload (LVPO) causes LV hypertrophy and resistance to LV filling, notably increased LV chamber stiffness and LV myocardial stiffness (Kc, Km, respectively), and ultimately causes increased pulmonary capillary wedge pressure (PCWP) and the development of heart failure with preserved ejection fraction (HFpEF). Exercise programs in HFpEF patients have been promising, but whether an exercise program superimposed with progressive LVPO would alter LV stiffness properties and thus HFpEF progression remains unclear. Pigs (25 kg) underwent progressive LVPO for 5 weeks without (n=8) or with daily exercise (n=8, 10 degrees elevation, 2.5 mph, 10 min, 5 days/week). LV function and geometry was determined at baseline and weekly by transthoracic echocardiography whereby Kc and Km were computed by validated algorithms including speckle tracking echocardiography (Figure). In both LVPO groups, LV mass increased by over 55% from baseline, and while Kc and Km increased in a time dependent manner with LVPO, the increase in LV stiffness properties was significantly reduced in the LVPO exercise group, which was particularly evident for Km. At 5 weeks, PCWP was lower in the LVPO exercise group (10.52 ± 0.35 vs 11.88 ± 0.34 mmHg, p<0.05). LV collagen percent area by histomorphometry was reduced in the LVPO exercise group compared to LVPO (5.96 ± 0.50 vs 10.82 ± 0.39 %, p<0.05). Thus, this model of progressive LVPO caused time dependent increases in LV stiffness properties, fibrosis and emergence of a HFpEF phenotype whereby these changes were blunted with a superimposed exercise protocol. The unique and significant findings from this study were that with a continuous and progressive LVPO stimulus, a superimposed regular exercise protocol did not alter the LV hypertrophic response, but reduced time dependent increases in LV stiffness properties, particularly Km, and a structural basis for this effect was the prevention of myocardial fibrosis.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Miller, Sienna	McQuail, Joseph	Ketogenic Feeding Induces Selective and Context-Dependent Mitochondrial Remodeling in the Aging Hippocampus View Full Text Abstract Text Aging is associated with reduced cerebral glucose utilization and altered mitochondrial oxidative phosphorylation (OXPHOS), potentially contributing to cognitive vulnerability. Ketone bodies provide an alternative metabolic substrate, but it remains unclear whether dietary ketosis induces selective remodeling of hippocampal mitochondrial proteins and whether such changes relate to spatial memory performance across age and sex. Male and female rats aged 6 months (young) and 24 months (aged) were maintained on ad libitum chow (AL-CHOW), time-restricted carbohydrate diet (TRF-CARB), or time-restricted ketogenic medium chain triglyceride diet (TRF-KMCT). Spatial learning was assessed using the Morris Water Maze. Hippocampal synaptosomal fractions were isolated, and mitochondrial protein expression was quantified via Western blot. Data were analyzed using three-way ANOVA (Sex × Age × Diet) and hierarchical regression predicting Spatial Learning Index (SLI). Diet regulated mitochondrial proteins in a selective manner MTCO1 (Complex IV) exhibited a significant main effect of diet, with reduced expression in TRF-KMCT relative to AL-CHOW, independent of age and sex. ATP5A (Complex V) showed a significant Diet × Sex interaction, indicating sex-dependent modulation of ATP synthase expression across dietary conditions. TOM20, a marker of mitochondrial content, also demonstrated a significant main effect of diet, with reduced expression under ketogenic feeding. While most OXPHOS proteins were not directly associated with SLI, TOM20 exhibited a significant Diet × SLI interaction: higher TOM20 expression was positively associated with poorer spatial learning in AL-CHOW animals but not in time-restricted diet groups. These findings demonstrate that ketogenic feeding induces selective and partially sex-dependent remodeling of hippocampal mitochondria. Together, these results suggest that metabolic interventions may influence cognitive vulnerability not through global enhancement of mitochondrial function, but through selective and context-dependent remodeling of specific mitochondrial components.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Dumych, Roman	Zeng, Qingli	VeriRouter - UAV Secure Routing View Full Text Abstract Text With the rising use of Unmanned Aerial Vehicles (UAVs), security has become an important factor in UAV networks. The devices’ functionality and the data that they transmit are constantly at risk of attacks and intrusions. VeriRoute, our lightweight packet‑level path‑commitment and delayed key‑disclosure mechanism. It appends short tags to each packet that is sent, which enables the receiver to verify the packet’s authenticity. We plan to implement VeriRoute in ns-3, a standard network simulator built in C++. We plan to test its performance against standard AODV/OLSR models and compare its effectiveness against blackhole and wormhole attacks. This paper focuses on the initial setup of the project, which includes installing ns-3, researching its functionality configuring the network topology, and implementing visual tools for easier data collection and analysis. This project heavily reinforces our understanding of network security, particularly intrusion detection and prevention, C++ programming and the implementation of external libraires, and extending the current libraries with our own modules.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Fyock, Madeline	Kisselev, Olesya	Tastes of Belonging: Food, Language, and Cultural Continuity Among Second-Generation Russophone Immigrants View Full Text Abstract Text As the Russian language increasingly loses its unifying role across diasporic communities, other cultural practices—particularly food and foodways—may be stepping in to sustain a sense of shared identity among Russophone/post-Soviet migrants. This project examines how members of the Russophone diaspora in the United States navigate shifting cultural allegiances in light of recent geopolitical ruptures, notably Russia’s full-scale invasion of Ukraine and the growing rejection of Russian linguistic and symbolic dominance. Russian heritage speakers, as representatives of the second generation of immigrant diasporas, often experience a weakening connection to the Russian language—due to limited exposure, shifting parental priorities, or local language environments (Polinsky, 2018). Yet many still engage with food-based traditions inherited from parents and grandparents. This study draws on qualitative interviews and surveys to investigate how food and foodways persist as meaningful semiotic resources that link younger generations to their familial and cultural histories (Mankekar, 2005; Miller & Deutsch, 2009). In the absence of strong linguistic continuity, can shared culinary practices serve as alternative markers of diasporic identity? How do second-generation individuals interpret, adapt, or reinvent food traditions associated with their family’s post-Soviet background? Our findings suggest that food—often embedded in routines of holiday celebration, storytelling, and intergenerational interaction—frequently plays a central role in sustaining cultural memory and emotional connection to heritage, even when language proficiency fades. By focusing on the cultural lives of heritage speakers, this research sheds light on how everyday practices help construct and preserve diasporic identities. It also complicates assumptions about cultural loss by showing that while language may recede, other modes of cultural expression, such as food, remain resilient and dynamic (Pavlenko, 2011).	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Lewis, Hannah	Quattro, Joe	Applications of Near-Infrared Spectroscopy to Cryptic Species Management View Full Text Abstract Text Two species of morphologically indistinguishable, and therefore ‘cryptic’, hammerhead shark species are known to use estuarine systems in South Carolina as nursery areas. The recently described Carolina hammerhead, Sphyrna gilberti, is externally indistinguishable but co-occurs with the scalloped hammerhead, S. lewini. Applications of Near-Infrared Spectroscopy (NIRS) have recently been described as a method that differentiates closely related animal species but has yet to be applied to cartilaginous fishes. Using NIRS absorbance data and Fourier-transformed statistics, the technology can be portable thereby allowing a rapid and non-invasive determination of species identification in the field. I hypothesized that NIRS would be a rapid and robust method for differentiating cryptic species and therefore be useful for field expedient, non-invasive identifications of S. gilberti and S. lewini. Tissue biopsies taken from the dorsal, anal, pectoral, and caudal (upper and lower lobes) fins using a paper punch. Individual tissue samples were assigned a dummy variable of 0 or 1 (S. lewini or S. gilberti) and then scanned on a Bruker Matrix-I Near Infrared Spectrometer. Data for each individual NIRS scan were parsed the OPUS suite of statistical software for statistical analysis. My results suggest that fin biopsies and the NIRS approach are not suitable for accurately distinguishing this cryptic species pair. I am currently using this approach on other tissue types (e.g., teeth and scales) to determine if other tissue biopsies will yield results in distinguishing this cryptic species pair. Comparatively little is known about the distribution of S. gilberti within and among estuarine systems along the southeastern US and the NIRS approach represents a cost-effective and real-time solution to species discrimination that contributes to rare species management.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
McElveen, Kennerly	Wright, Pamela	Coping Among Women with PCOS: A Comparative Analysis View Full Text Abstract Text Polycystic ovary syndrome (PCOS) a common chronic endocrinopathy, affects ~13% of reproductive-aged women globally. PCOS is a complex, heterogenous collection of symptoms involving hormonal and metabolic dysregulation. Notable symptoms are hirsutism, menstrual irregularities, visceral adiposity, insulin resistance, and subfertility, all which negatively impact quality of life. Women with PCOS are at increased risk of anxiety and depression, as well as other mental health disorders. However, limited research exists on coping strategies used among women with PCOS. The purpose of this study was to examine coping strategies used among women with PCOS and compare to women with no chronic health conditions. Participants were recruited via flyers and social media. Implied informed consent was obtained. The survey was comprised of demographic questions and the BriefCOPE and Adult Coping Inventories (ACI). Data were collected via REDCap. Means/standard deviations were calculated for continuous variables, frequencies for categorical variables, and independent sample t-tests for mean differences between the PCOS group (n=121) and healthy control (HC) group (n=168) on inventory scores. Participants (N=289) were 33.73 (±7.53) years and mostly White (69%). The groups did not significantly differ in baseline characteristics. On the BriefCOPE Inventory, women with PCOS used more emotion-focused coping and avoidance compared to the HC (p<0.001). On the ACI, women with PCOS scored significantly higher than the HC for using maladaptive coping strategies and avoidance (p=0.002 and 0.018, respectively). Poor coping strategies in women with PCOS may be linked to the psychological distress of chronic PCOS symptoms such as hirsutism, acne, subfertility, and depression. As women with a chronic health condition, poor coping skills may reflect a perceived lack of control over the condition and feelings of helplessness. Future research is needed to understand the impact of PCOS on developing poor coping strategies and identify clinical timepoints and measures to promote healthy coping strategies.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Pallapothu, Sriya	Wenceslau, Camilla Townsend, Paul Pernomian, Laena Parente, Juliana Conway, Molly Gibbs, Tiereney	Hypertension-like stretch induces brain endothelial damage View Full Text Abstract Text Hypertension affects almost one-half of adults and increases the risk of stroke, dementia, and heart failure. A key contributor to hypertension is dysfunction of endothelial cells, which line blood vessels and regulate vascular tone. Under hypertensive stress, these cells undergo endothelial-to-mesenchymal transition (EndMT), where they lose their protective endothelial identity and adopt a stiff, muscle-like phenotype. Hypertension is also characterized by inflammation, and prior work found increased expression of the immune receptor formyl peptide receptor 1 (FPR1) in hypertensive conditions. However, whether inflammatory signaling through FPR1 contributes to EndMT remains unknown. In this study, murine brain endothelial cells underwent physiological (normotension) (5%) or hypertensive (20%) mechanical stretch, with or without FPR1 or FPR2 inhibitors. Western blots assessed protein expression associated with mesenchymal features, and results showed that hypertension-like stretch changed the endothelial cell cytoskeleton. By clarifying how inflammatory signaling drives harmful endothelial changes, this work explores early mechanisms underlying hypertension and potential targets to prevent disease progression.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Johnson, Marissa	Toll, Katherine	Evolution of Anthocyanin Pigments in M. guttatus Across Soil Types View Full Text Abstract Text Serpentine soil is characterized by its low calcium-to-magnesium ratios, toxic heavy metals, and generally low nutrient content. Its low calcium levels substantially limit serpentine plant productivity, as calcium is essential for proper function and growth. Additionally, serpentine soils are shallow and have reduced vegetative cover, forcing serpentine endemics to adapt to the soil's high levels of UV radiation, hotter temperatures, and water scarcity. Anthocyanins are floral pigments that occur in both floral and vegetative tissue and provide plants with tolerance to abiotic stressors, such as heavy metals, UV radiation, and drought. The pigment also plays an important role in pollinator-mediated selection through floral display. Mimulus guttatus, or the yellow monkeyflower, has adapted to grow in both serpentine and nonserpentine soils. Using seeds from 8 populations of M. Guttatus (4 serpentine and 4 nonserpentine), grown in a common garden experiment, phenotypic traits and anthocyanin levels will be compared between serpentine and nonserpentine populations. We hypothesize that anthocyanin levels in serpentine populations will be elevated in floral and vegetative tissue as a result of local adaptation to the harsh abiotic stressors of the serpentine environment. Afterwards, machine learning and multivariate techniques will be employed on genetic, phenotypic, and visual data to summarize and predict pigment patterning on leaves and flowers from both serpentine vs. nonserpentine M. guttatus populations.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Bunton, Jesse Way, Jordyn	Kilpatrick, Eran	Supporting the University of South Carolina Salkehatchie Herbarium: An Undergraduate Research Experience through Palmetto College View Full Text Abstract Text Herbaria are collections of preserved plant specimens that are pressed, mounted, and stored in databases for research. Scientists use these specimens to study plant distribution, genetics, ecology, evolution, and biodiversity. The University of South Carolina Salkehatchie Herbarium (SALK), founded in 2013, is part of the Southeast Regional Network of Expertise and Collections (SERNEC), which connects over 200 herbaria across the Southeast. During this research experience, we mounted 158 dried plant specimens onto herbarium sheets, entered 212 records into the SERNEC database, and assisted in organizing the collection. Salkehatchie's Herbarium currently houses over 1,400 publicly available specimens through SERNEC and the Global Biodiversity Information Facility (GBIF). Collections like the one curated at the University of South Carolina Salkehatchie are important because they provide real, physical records that support research in biodiversity, systematics, ecology, and evolution.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Christy, Hunter	McQuillin, Samuel	Images or Not: Memorization Ability With or Without a Guide View Full Text Abstract Text The purpose of this experiment is to examine peoples’ ability to recall items from their short-term memory depending on how that information is presented to them, that is if that information has an accompaniment or not, or whether that accompaniment is lying. The hypothesis is that participants will on average score higher on the test with congruent accompaniments compared to the exams without an accompaniment. Furthermore, the test with incongruent accompaniments will have a lower average score than the other two tests. Participants will be convenience sampled around the University of South Carolina campus, and each of them will be asked to participate in an online survey individually. The first part will evaluate their abilities to create mental images in their head. The next three parts will evaluate short-term recall, with each section having a video, each containing a spoken list of ten words with three seconds between each word. The first video will be just a black screen, the second will have images that are congruent with the words (such as showing a photo of a beach while the word beach is spoken), and the third will have incongruent imagery (such as a photo of a baby when the word adult is spoken). Following the viewing of each video, the participants will be asked to write down as many words as they can remember. A Pearson’s R will be used to see if there is a correlation between participants’ ability to generate mental images and scores associated with the no-images video. A paired samples t-test will be used to compare the average scores associated with video with no images and the video containing congruent images. Finally, a repeated measures ANOVA will be used to compare the mean scores associated with all three videos.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Arcement, Jake	Hudac, Caitlin Benjamin-Cramer, Sophie Mace, Olivia	Auditory Hypersensitivity, Habituation, and Behavioral Dysregulation in Autism Spectrum Disorder View Full Text Abstract Text Auditory hypersensitivity and over-reactivity are among the most common sensory processing differences in individuals with Autism Spectrum Disorder (ASD) and have been linked to over-focused or “sticky” attention. Caregiver reports of auditory filtering difficulties are also associated with maladaptive behavioral outcomes, including both externalizing behaviors (e.g., impulsivity and hyperactivity) and internalizing behaviors (e.g., anxiety and perseveration). However, the neural mechanisms underlying auditory sensitivity and habituation, and how they relate to behavioral dysregulation in ASD, remain unclear. The present study used neural markers of attention to clarify the relationship between auditory processing and internalizing and externalizing symptom severity in ASD. Participants included 130 autistic and 86 non-autistic individuals ranging from early childhood through young adulthood. Participants completed an auditory oddball task during electroencephalography (EEG) recording, which included frequent and novel sounds. Neural sensitivity and habituation were indexed using P3 event-related potential (ERP) amplitude (125–450 ms), a marker of early attention orienting. Internalizing and externalizing behaviors were assessed via parent report using the Child Behavior Checklist. Results indicated that autistic participants showed different patterns of neural adaptation to novel sounds as a function of both internalizing and externalizing symptom severity. Higher internalizing and externalizing severity were associated with lower initial neural sensitivity to novel sounds, followed by sensitization across task progression rather than typical habituation. In contrast, non-autistic participants demonstrated adaptive habituation to novel sounds regardless of symptom severity. These findings suggest that heightened behavioral dysregulation in ASD is linked to atypical neural attention patterns, characterized by over-focused attention and lack of habituation to novel sounds. Together, these results offer a potential neural explanation for the co-occurrence of under- and over-responsiveness to auditory stimuli in ASD, and they underscore the importance of sensory-based interventions for addressing maladaptive internalizing and externalizing behaviors.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
May, Zoe	Pellegrini, Christine Jamieson, Scott Horn, Kailyn	Perceived Competence and its Influence on Pain and Activity View Full Text Abstract Text Introduction: Limited research exists on the influence of one’s perceived competence of physical activity (PA) on pain, function, and activity levels after-total knee replacement (TKR). This study examined the association between perceived competence of PA with pain, function, and PA in adults with TKR. Methods: This was a secondary analysis of baseline data from a randomized trial examining the effects of a weight loss intervention after TKR. Participants completed the 1) Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), which has 3 subscales (pain, fitness, physical function). Participants responded to 5 items on a Likert scale none (0) to extreme (4))2) Knee Injury and Osteoarthritis Outcome Score (KOOS) has 5 subscales (pain, activities of daily living, sports/recreation, quality of life) with 5 items on a 5-point Likert Scale (0 (never/none) to 4 (always/extreme)) And 3) Perceived competence of PA is a 4-item survey (Likert scale from 1 (not at all true) to 7 (very true)). Participants wore Actigraph accelerometers on waists for 7 days for ≥10 hours/day to measure moderate-to-vigorous intensity physical activity (MVPA) (min/week) and steps/day. Linear regressions examined the relationship between perceived competence with pain, perception of knee health, and PA using SPSS (v29). Results: Participants (n=179) were 68.2% female, 73.3% white, 80.59±20.60 days since TKR, 65.96±8.39 years, with a BMI of 33.91±4.57kg/m2. Perceived competence significantly predicted MVPA levels, (β = 3.145, p <0.003, R² = .50) and steps/day (β = 74.940, p <0.006, R² = .42). Higher perceived competence predicted all higher KOOS scores (p≤0.026) except KOOS Sport (p=0.190). Higher perceived competence predicted all lower WOMAC scores (p≤0.009). Conclusion: Perceived competence of activity predicted pain, function, and activity in adults with knee replacement. Identifying perceived competence prior to PA or rehab programs for post-surgical populations may help optimize intervention strategies and support clinical outcomes.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Nanda, Chitra	Sigfus, Kristinsson	Interacting Effects of Race and Lesion Volume on Aphasia Severity View Full Text Abstract Text Post-stroke aphasia impairs language production and comprehension (Berthier, 2005). Recovery is influenced by stroke-specific factors such as severity, lesion size, and location. Additionally, patient-specific factors like age, cognitive reserve, psychosocial support, and socio-economic status also impact outcomes (Kristinsson et al., 2022; Gadson et al., 2022). Recent work suggests that race is similarly a determining factor for recovery outcomes, with African American stroke survivors experiencing more severe aphasia compared to White individuals. Potential reasons for this effect include inequities in healthcare access, access to rehabilitation, and social determinants of health (Gadson et al., 2022). However, previous studies are scarce and generally include a relatively small sample of research participants, which limits the extent to which these findings may generalize across studies. The present study aimed to address this gap by examining the effect of race on aphasia severity after accounting for demographic and lesion variables associated with recovery in a large cohort of chronic stroke survivors. Specifically, this study researches the interaction between race and aphasia severity in post-stroke patients. The sample included 139 White and 39 African American participants that have left hemisphere post-stroke aphasia. Chi-square tests and independent t-test calculated the racial difference in provided factors. Regression analyses measured the effect of race on aphasia severity (WAB-AQ scores) after controlling for sex, stroke age, lesion volume, and time post-onset. Results showed that African American participants had WAB-AQ scores 12.4 points less than White participants. This indicated that they experienced more severe aphasia, even if lesion size and other affecting variables were controlled. These results suggest that racial disparities in stroke recovery may impact recovery. By emphasizing the relationship between race and structural inequities in aphasia severity outcomes, this research promotes the need for equity in access to post-stroke rehabilitation.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Gulczinski, Rachel	Tucker, Curisa Hickey, Patrick	Informed Consent in Childbirth: A Global Scoping Review of Episiotomy Practices and The Gaps in U.S. Perinatal Care View Full Text Abstract Text Purpose: The objective of this study was to examine the existing literature documenting whether informed consent is obtained for episiotomy procedures during childbirth. Background: Informed consent is a fundamental ethical and legal component of perinatal care. Despite this, current evidence suggests that many childbirth interventions, including episiotomies, are often performed without explicit consent. Episiotomy remains highly associated with non-consented care and obstetric violence. Therefore, this scoping review aimed to evaluate whether informed consent is obtained for episiotomy, understand experiences of disrespect and overmedicalization, and identify gaps in U.S. practices. Methods: Following the PRISMA Scoping Review (PRISMA-ScR) guidelines, peer-reviewed studies published in English from 2015 to 2025 were searched in PubMed, Embase, and Web of Science. Eligible studies assessed informed consent practices and documented experiences of disrespectful care or unnecessary procedures during childbirth. Following full-text review, 17 studies were included in the final analysis and included data from 15 countries across Asia, Africa, North America, South America, and Europe. Results: Findings indicate global deficiencies in obtaining informed consent during childbirth interventions, including episiotomies, with some settings reporting non-consent rates as high as 40-70%. Additionally, many countries reported an episiotomy rate significantly higher than the World Health Organization’s recommended threshold of 10%, including Nigeria (62%), Ecuador (35.7%), and Hungary (62%). The deficiencies in consent and high episiotomy rates reflected in these studies indicate high rates of disrespect that lead to birth dissatisfaction, lack of perceived control, and poorer birth outcomes. Implications: This review demonstrates that non-consented and unnecessary obstetric interventions remain prevalent despite the recognition of the harms associated with routine episiotomy. The findings also highlight gaps in the standardization of informed consent practices, particularly within the United States. By analyzing global maternal healthcare systems, these findings identify gaps in care and provide the framework to improve informed consent procedures during labor.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Williams, Abigail	Poulain, Fabienne E.	Expression of Latrophilin-3 in the developing visual system in vivo View Full Text Abstract Text Precise wiring of neural circuits is critical for proper development and function of the central nervous system. In the visual system, dorsal and ventral retinal ganglion cells (RGCs) extend their axons toward the visual processing center known as the optic tectum in non-mammalian vertebrates. During development, some dorsal retinal axons initially misroute along the dorsal branch of the optic tract but then selectively and locally degenerate. Using zebrafish as a model, our previous work has shown that trans-axonal signaling initiated by pioneer ventral axons instructs the pruning of missorted axons in the optic tract. At the molecular level, Glypican-3 and Teneurin-3 located at the surface of ventral retinal axons signal to Latrophilin-3.1 (Lphn3.1) located at the surface of missorted dorsal axons. While these results point to a novel function of Lphn3.1 in axonal pruning, which specific domains of Lphn3.1 are required to instruct degeneration remain unknown. To address this question, we established several stable transgenic lines expressing Lphn3.1 (control) or Lphn3.1 variants fused to EGFP under the control of the RGC-specific promoter isl2b. Here, I analyzed three different alleles of Tg[isl2b:adgrl3.1-EGFP] expressing different levels of Lphn3.1-EGFP that may differentially impact retinotectal circuit development. Using RT-PCR, I quantified adgrl3.1-EGFP expression at 54 hours post-fertilization (hpf) and identified the line with the most robust and consistent expression. I then performed lipophilic dye injections in the dorsal retina of adgrl3.1-EGFP transgenic embryos and EGFP controls at 54 and 72 hpf to selectively label dorsal RGC axons. Confocal imaging of dorsal axons along the optic tract suggests that expressing different levels of Lphn3.1-EGFP differently affects the persistence of missorted dorsal axons within the optic tract, consistent with a role for Lphn3.1 in mediating selective axon degeneration. Future work will test whether expressing different Lphn3.1 variants triggers axon degeneration.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Thomas, Sandra Prince	Welshhans, Kristy	Altered local translation in Down Syndrome fibroblasts View Full Text Abstract Text Down syndrome is a neurodevelopmental disorder caused by the triplication of human chromosome 21 (T21). It is characterized by developmental delays and intellectual disability. T21 causes genome-wide alterations, thereby dysregulating many physiological and molecular processes. One such dysregulated mechanism is local translation of mRNAs, which is critical for rapid protein synthesis in response to extracellular cues. Studies using various Down syndrome models have shown that global protein synthesis is decreased; however, little is known about how local mRNA translation in subcellular regions is affected. The fibroblast leading edge is highly dynamic, motile, and responds to various extracellular cues. Furthermore, previous work from our lab shows that Down syndrome fibroblasts have altered motility. Thus, we hypothesized that local translation is decreased in the leading edge of fibroblasts from individuals with Down syndrome. We performed a puromycin assay to fluorescently label newly synthesized proteins in fibroblasts from age- and sex-matched apparently healthy (Control) and Down syndrome (T21) individuals. Each group was starved in media lacking growth factors, and then stimulated with media containing either fetal bovine serum (FBS) or vehicle (without FBS), followed by puromycin treatment and fixation. In addition to puromycin, we stained for paxillin, which is a member of the focal adhesion complex where local translation occurs. Local translation in the leading edge of T21 fibroblasts was significantly decreased in both vehicle and FBS-stimulated conditions compared to Control fibroblasts. Interestingly, paxillin puncta in the leading edge were decreased in Control FBS-stimulated fibroblasts compared to Control vehicle fibroblasts. In contrast, paxillin density was significantly increased in the T21 FBS-stimulated group compared to the Control FBS-stimulated group. These data suggest that local translation and possibly adhesion turnover are dysregulated in T21 fibroblasts. These changes may underlie impaired cell motility, proteostasis, and other molecular pathways that contribute to Down syndrome pathology.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Mitchell, Emerson	Rizos, Dimitris	RVTI Derailment Simulations Based on Incomplete Field Data View Full Text Abstract Text Train derailments result in financial losses, personal injuries, and even loss of life with significant environmental and public health impacts. One major root cause of derailments is attributed to the dynamic interaction between a moving train and the supporting track in the presence of defects in the track and/or rolling stock. One derailment mitigation approach is predicting train-track interaction forces through computer simulations. Existing vehicle–track interaction (VTI) simulators typically require a tradeoff between computational efficiency and model fidelity and often simplify or omit spatial variation in track conditions. Rapid VTI (RVTI) is a high-fidelity computer simulation tool, developed at USC that captures spatially varying track conditions at substantially reduced computational cost. RVTI, however, requires inputs that are not reported in routine inspection and track-geometry data, forcing literature—or experience—based assumptions. This study addresses this gap by quantifying the impact of assumed parameters on derailment-potential predictions, by identifying the most critical parameters, and providing evidence-based estimates for those based on available field data. The objectives of the proposed work are to: (I) qualify the relative importance of the unspecified RVTI model parameters in accuracy and efficiency of simulations, (II) use accident reports to demonstrate and validate the use of calibrated RVTI models to predict derailments, (III) use the RVTI simulator within a parametric study framework to develop training datasets for future Machine Learning (ML) implementation. Early work on this project has established baseline values and ranges for several unspecified RVTI model parameters. A Monte Carlo-based analysis has also been established and tested on a simplified proxy model. Current effort includes running RVTI within the Monte Carlo analysis framework to quantify the most impactful parameters and using the information from those simulations in a parametric sensitivity study, to measure the importance and higher-order interactions of parameters.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Imhoff, Conor	Tompkins, Renarta	Building Automaticity: The Impact of Orthographic Mapping and Guided Repeated Reading on Third-Grade Fluency View Full Text Abstract Text This study examines the impact of a small-group fluency intervention designed to increase reading automaticity through orthographic mapping and guided repeated reading. Conducted over nine weeks in a third-grade classroom, the intervention maintained a consistent instructional routine while allowing for data-driven adjustments based on student performance. Three students were selected based on running records and classroom observations. Although decoding accuracy ranged from 93% to 97.5%, all students demonstrated fluency inefficiencies, including frequent hesitations, word-by-word reading, inconsistent phrasing, and difficulty maintaining place in text. Baseline oral reading rates ranged from 93 to 146 Words Correct Per Minute (WCPM). Instruction focused on strengthening automatic word recognition by reinforcing connections between phonology, orthography, and meaning. Progress monitoring was conducted weekly using one-minute cold reads from previously unseen grade-level passages. Measures included WCPM, accuracy, and hesitation frequency. The instructional goal was for students to increase reading rate by approximately 20 WCPM while maintaining at least 95% accuracy and demonstrating reduced hesitation. This study provides classroom-based evidence on the effectiveness of structured, brief fluency intervention to support increased reading efficiency and automatic word recognition.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Kral, Marsh	Tang, Chuanbing Hossain, Md Waliullah	Investigating the Antibacterial Activity of a Cationic Metallopolymer View Full Text Abstract Text Antibiotic resistance as a global health crisis has necessitated the development of effective drug candidates with alternative mechanisms. Host-defense peptides are part of the innate immune system and serve as one of the first lines of defense against pathogens, but their therapeutic applications are limited by cost and scalability. However, cationic metallopolymers (or metal-containing polymers) offer a unique approach in that they may act independently or in complement with traditional antibiotics and functionally mimic natural, host defense peptides. The cobaltocenium (CC) cationic unit in these polymers is composed of a positively charged cobalt center surrounded by two hydrophobic cyclopentadiene rings, allowing it to interact with bacterial membranes and biofilms. Most recently, this CC motif was incorporated into the polymer backbone to yield a main chain cationic polymer, where a marked increase in potency was observed compared to its side chain counterpart. Investigations into the mechanism by which the main chain polymer acts were conducted, as well as a thorough investigation of its antibacterial activity. Studies revealed that the main chain polymer depolarizes and permeabilizes the membrane and kills both gram-positive and gram-negative species within minutes to an hour. A decrease in biofilm biomass was observed in treatment groups, and biofilm embedded bacterial cells were found to be significantly reduced. Additionally, multi-drug resistant (MDR) bacteria did not develop any resistance to the polymer over the course of 21 days. These results demonstrate the potential of cationic metallopolymers as a novel class of drug candidates for MDR-bacterial infections and provide insight into the structure-activity relationship of cationic metallopolymers.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Smith, Ellison	Christ, Christa	EXAMINING THE ROLE OF HUMOR STYLES AND MATING CONTEXTS ON MATE DESIRABILITY View Full Text Abstract Text Humor plays a critical role in facilitating group cohesion and reducing social tensions. Examining humor from an evolutionary perspective may explain why individuals are attracted to certain humor styles and how these preferences shape humor perceptions. Sexual selection has contributed to consistent patterns: women prefer men who produce humor, whereas men often prefer women who appreciate it. Preferences also vary across humor styles, with affiliative and self‑deprecating humor generally viewed as more attractive. Despite extensive research on these dimensions, little work has examined preferences for clean versus dirty humor. Humor styles may also differ across mating contexts due to their signal of parental investment levels. Medlin et al. (2018) remains the only study to directly investigate this distinction, finding that clean humor was preferred overall across both short‑term (STM) and long‑term (LTM) mating contexts, but it was especially appealing for LTM contexts, which aligns with evolutionary theory, as dirty humor signals potentially lower likelihood of parental investment. To further examine this relationship in our current study, participants were placed in a hypothetical date scenario, in which they are invited to view a comedy performance, and learned that the hypothetical date has the same humor style (clean or dirty) as the comedian. Participants then rated their willingness to engage further with this date under both STM and LTM contexts. Participants also completed questionnaires relevant to dating, humor preferences, life history, and demographics. Data collection is ongoing. Analyses will be conducted to examine dating interest across humor styles and mating contexts. This study contributes to previous literature by identifying if there is a preference for clean vs. dirty humor across both STM and LTM contexts, as well as opening new avenues to explore this relationship across gender and life history strategies.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Chrif, Sarah	Roberts, Jane Arnold, Holley	Early RSA Reactivity as a Predictor of ADHD Symptoms in Children with Fragile X Syndrome View Full Text Abstract Text Fragile X syndrome (FXS) is the most common inherited cause of intellectual disability and is frequently associated with difficulties in emotion regulation and increased attention-deficit/hyperactivity disorder (ADHD) symptoms (Grefer et al., 2016). While prior research has found that early cardiac activity predicts later autistic behaviors in FXS (Roberts et al., 2012), it remains unclear whether early autonomic regulation specifically predicts later ADHD symptom severity. Increasing evidence suggests that atypical parasympathetic functioning may contribute to emotion regulation and attentional difficulties (Beauchaine & Thayer, 2015; Klusek et al., 2013). This project examines respiratory sinus arrhythmia (RSA), a heart rate variability measure indexing parasympathetic nervous system activity. RSA was measured during the Laboratory Temperament Assessment Battery (Lab-TAB) arm restraint task (Goldsmith & Rothbart, 1994) in children with FXS between 12-24 months of age. During this task, children were first allowed to play with a toy before being gently restrained by a parent while the toy is visible but out of reach, eliciting frustration. RSA reactivity was calculated as the difference between baseline play and the frustration condition, with decreases in RSA reflecting parasympathetic withdrawal. ADHD symptoms at preschool age (3-6 years) are assessed using the Preschool Age Psychiatric Assessment, a structured parent interview measuring DSM-based ADHD symptoms in young children (Egger & Angold, 2006). We hypothesize that blunted RSA withdrawal from baseline during the frustration task will be associated with greater ADHD symptom severity at preschool age. The current sample will include approximately 25 children with FXS. Regression analyses will be conducted to examine the relationship between early RSA reactivity and later ADHD symptom severity. By characterizing early autonomic reactivity in FXS, this project aims to better understand the biological mechanisms underlying regulatory difficulties in this population. Identifying early physiological markers may help clarify developmental processes linked to later attentional and behavioral challenges.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Szilveszter, Allaina Colino, Ainhoa	Roach, Alexandra	Observable Differences in Physiological Markers of Respiratory Vagal Nerve Stimulation in Deep Breathing Mindfulness Training View Full Text Abstract Text Deep breathing exercises, a core component of mindfulness practices, stimulate the vagus nerve. The vagus nerve innervates the majority of nerves in the parasympathetic nervous system, stimulation of this nerve pair can influence widespread processes including heart rate, blood pressure, respiration, and pain perception. In this study, we used Biopac Bionomadix wireless transmitters to collect physiological data including electrocardiogram, electrodermal activity, electromyography, respiration, and pulse during a stress test. In this within-subjects design, we used a TENS unit to introduce stress in the form of mechanical pain via transdermal electrical stimulation to establish participants' pain threshold and pain tolerance. Perceived pain was measured using the Visual Analog Scale and the McGill Pain Questionnaire at baseline, during vagal nerve stimulation (or control), and post intervention. Participants will select the words that best describe their current pain, which will then be scored based on intensity rankings. These subjective pain ratings were compared to physiological data gathered in search of consistent biomarkers of stress among participants. Vagal nerve stimulation was achieved through deep breathing mindfulness training, utilizing slow, deep breathing with low inspiration or expiration ratio. During the experimental session, participants were guided in a 2 minute “box breathing” session where they were instructed to inhale for 5 beats, hold for 5 beats, exhale for 5 beats, and hold for 5 beats. The control condition did not provide participants with guidance on breathing, allowing for non-paced, regular breathing to be observed during treatment with the TENS unit. Physiological data were recorded continuously and processed using AcqKnowledge Data Acquisition and Analysis Software. We hypothesized that the physiological difference between baseline and deep breathing, compared to baseline and undirected quiet, was greater, indicating that perceived pain was attenuated or reduced by the box breathing technique.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Shull, Anna	Xu, Peisheng Wang, Mingming	Assessing Blood Brain Barrier Integrity After Nanoparticle-Mediated CNS Drug Delivery in Alzheimer’s Disease View Full Text Abstract Text Alzheimer’s disease (AD) is a neurodegenerative disorder defined by progressive cognitive decline, with its underlying pathogenesis remaining incompletely understood. Although numerous pharmaceuticals show promise in mitigating AD-related pathology in vitro, their clinical efficacy is often limited by poor penetration of the blood-brain barrier (BBB). To address this challenge, our laboratory has developed a brain-targeted nanoparticle drug delivery system (TN-D) capable of transporting diverse compounds into the brain. While targeted nanoparticle systems enhance CNS drug bioavailability, their effects on cerebrovascular integrity require rigorous evaluation. Here, we assess whether TN-D administration alters cerebrovascular architecture or compromises BBB integrity in a murine model of AD. Vascular structure and tight junction integrity are evaluated using immunohistochemical analyses of endothelial and junctional markers, including CD31, ZO-1, and Occludin, across multiple nanoparticle formulations. These studies aim to determine whether TN-D delivery preserves vascular structure and BBB integrity, thereby supporting its safety profile as a therapeutic platform for AD. Findings from this ongoing work will inform the development of nanoparticle-based strategies for safe and effective CNS drug delivery.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Chinnasami, Nishant	Karakchi, Rasha	Hybrid Monitoring for Side-Channel Security in Edge SoCs View Full Text Abstract Text Edge-class SoCs, widely used in IoT and embedded devices such as IoT gateways, smart meters, medical devices, surveillance cameras, and industrial controllers, face increasing exposure to side-channel and fault injection attacks due to their deployment in untrusted environments and strict power and resource constraints. Traditional defenses, such as constant-time coding or hardware redundancy, are often infeasible on these lightweight platforms. To address this challenge, we present a hybrid cryptographic monitoring system that combines statistical thresholding with machine learning (ML) to detect anomalies in real time. Using injected timing delays and ciphertext alteration, we evaluated two complementary detectors: a lightweight threshold-based monitor and a Random Forest classifier leveraging timing and ciphertext features. Implemented on the PYNQ-Z1, the framework achieves <5 ms inference latency with under 30% resource utilization. The results show that the hybrid approach improves accuracy and reduces false positives/negatives compared to threshold-only detection, offering a practical solution to strength cryptographic resilience in edge-class SoCs.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Srinivasan, Anish	Vasquez, Paula	Uncertainty Quantification of the Basic Reproduction Number (R0) in a Modified SEIR Model Using Sobol Sensitivity Analysis View Full Text Abstract Text Mathematical modeling is a critical tool for predicting epidemic trajectories and informing public health interventions. However, traditional Susceptible-Exposed-Infectious-Recovered (SEIR) frameworks often suffer from unrealistic assumptions, most notably the use of exponentially distributed latent and infectious periods, as well as a lack of distinction between symptomatic and asymptomatic transmission. This study used a modified model that addresses these limitations by incorporating Erlang distributions with subcompartments while also explicitly modeling both symptomatic and asymptomatic transmission pathways. The research focuses on quantifying how variability in model input parameters influence the uncertainty of the Basic Reproductive Number (R0). Using the Next Generation Matrix (NGM) as a foundational framework, we found an explicit algebraic derivation of R0 proved prohibitively complex for our model. Therefore, we used the NGM method within a simulation framework to compute R0 for many parameter combinations generated via Saltelli sampling. This dataset was used to perform a global variance-based Sobol sensitivity analysis. The analysis identifies the symptomatic transmission rate (bS), the proportion of asymptomatic infections (k1), and the daily isolation rate (dI) as the primary drivers of R0 variance. Conversely, the Erland parameters m and n, describing the number of latent and infectious subcompartments, had negligible sensitivity, indicating that R0 uncertainty does not come from the model design. Significantly, the Total-Order indices were nearly double the First-Order indices for key parameters, indicating that R0 uncertainty is dominated by non-linear parameter interactions rather than additive effects. These findings imply that reducing uncertainty in single parameters provides diminishing returns. Therefore, effective pandemic preparedness requires a holistic approach, combining isolation with broad screening to identify asymptomatic reservoirs, as uncertainty in one parameter can greatly amplify the uncertainty in others.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Atkinson, Allison	Mulkey, Malissa McDonnell, Karen Owens, Shaun	Comparing Health Perceptions and Care Quality in Dementia Care: A Multi-Methods Study Protocol View Full Text Abstract Text Background: The effects of Alzheimer’s disease and related dementias (ADRD) present substantial challenges for individuals living with cognitive impairment and their caregivers, particularly regarding quality of life. Prior research shows a discrepancy between how individuals with ADRD perceive their health-related quality of life (HRQoL) versus how caregivers view the HRQoL of those with ADRD. However, limited evidence exists on how these perceptual discrepancies influence caregiving experiences, communication, and care quality. Objective: This multi-methods study aims to assess concordance between individuals with ADRD and their caregivers regarding patient HRQoL and examine how perceptual discrepancies relate to caregiving experiences, communication, and overall care quality. Methods: A comparative cross-sectional design will collect quantitative data from 46 patient-caregiver dyads. Each dyad will consist of an individual with mild to moderate ADRD and their primary caregiver. Participants will be recruited from local healthcare providers, senior care facilities, and support groups. Participants will be at least 18 years of age and speak English. Participants with ADRD must score 10-25 points on the Montreal Cognitive Assessment. The Quality of Life in Alzheimer’s Disease scale will be used as well as demographic and caregiving data collection forms. Caregiving data includes number of hours spent providing direct care and the caregiver’s relationship to the participant with ADRD. A subsample of five dyads will participate in semi-structured qualitative interviews to explore communication, caregiving relationships, and the impact of HRQoL perceptions on care quality. Paired t-tests and Wilcoxon matched-pairs rank tests will analyze quantitative HRQoL concordance data. Qualitative data analysis will follow a thematic approach. Discussion: Findings will inform caregiver education, strengthen communication strategies, and support care approaches aligned with patients’ lived experiences. Ultimately, this study seeks to bridge perceptual gaps in ADRD care to improve care quality and quality of life for individuals living with ADRD and their caregivers.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Elya, Rita	Burkart, Sarah Randolph, Griffin	Evaluation of WP200 in a Community Sleep Lab Setting: A Retrospective Chart Review View Full Text Abstract Text Purpose: We investigated the percentage of false negatives and associated characteristics of individuals who had a Home Sleep Apnea Test (WatchPat200; WP200) using retrospective data from a sleep clinic in South Carolina. Methods: Between February 6, 2024, and March 14, 2025, adults (n=84, age= 51.3± 14.7 years, 57% female) with high probability for Obstructive Sleep Apnea (OSA) underwent home testing to determine presence of OSA. Those with negative home tests underwent an in-lab sleep test (polysomnography; PSG) to confirm OSA diagnosis. The percentage of false negatives for WP200 was calculated, and logistic regression was used to examine potential associated characteristics. Results: Among those who completed both tests (n=37), the percentage of false negatives was 51.35%. We observed a statistically significant relationship between probability of false negative and age (OR= 0.88; 95% CI= 0.80–0.97) and daytime sleepiness (OR= 1.40; 95% CI= 1.00–1.96). There was no statistically significant difference between prescriber type and WP200 results. Discussion: The percentage of false negatives was higher than we had predicted. Additionally, while the relationships between age, sex, and false negative results were predicted, our findings demonstrated an unexpected relationship between excessive daytime sleepiness and probability of false negative result. Future research should conduct simultaneous PSG and WP200 to comprehensively assess performance.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Caudillo, Yair	Fadel, James	Orexin Signaling as a Requisite Mediator for LPS-Induced TLR4 Translocation in Basal Forebrain Cholinergic Neurons View Full Text Abstract Text Introduction: Neuroinflammation is a primary driver of structural and functional decline in the basal forebrain cholinergic system. The recruitment of Toll-like Receptor 4 (TLR4) from intracellular compartments to the plasma membrane is a critical "gatekeeping" step in the initiation of the inflammatory cascade. While the orexin (hypocretin) system is known to modulate neuroimmune responses, its specific role in the physical trafficking of TLR4 within neurons remains poorly understood. Methods: We utilized a 35-rat cohort (ChAT-SAP/Orexin-Antisense) to investigate whether orexin signaling is necessary for TLR4 mobilization. Using a randomized spatial analysis ("Donut Method"), we isolated the 2μm membrane shell from the cytoplasmic core in over 175 ChAT-positive neurons. A Translocation Index (Shell:Core intensity) and Area Fraction Ratios were calculated to quantify protein recruitment. Results: Lipopolysaccharide (LPS) challenge in control rats induced a robust mobilization of TLR4 to the membrane, resulting in a significantly elevated Translocation Index of 1.69 ± 0.08. This recruitment was accompanied by a collapse in soma morphology, with roundness scores dropping to 0.69 ± 0.02 (indicating inflammatory atrophy). Conversely, orexin knockdown via antisense significantly attenuated this trafficking, maintaining a Translocation Index of 1.36 ± 0.11—effectively stranding the receptor in the cytoplasmic core. This "recruitment failure" was further evidenced by a reduction in the Shell:Core Area Fraction Ratio (from 1.85 in controls to 1.23 in antisense males). Notably, the blockade of TLR4 trafficking in antisense rats preserved soma roundness at healthy baseline levels (0.76 ± 0.02). Conclusion: Our findings demonstrate that orexin signaling is a requisite factor for the translocation of TLR4 to the neuronal membrane. By blocking this molecular trafficking, orexin knockdown prevents the structural remodeling and atrophy associated with acute neuroinflammation. These results suggest that the "functional impairment" previously observed with orexin loss may be a trade-off for significant structural neuroprotection against TLR4-mediated inflammatory stress.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Hudson, Dylan	Alberts, Halley	Baseline Characteristics, Care Gaps, and Barriers Among Adults With Diabetes Enrolled in a Community-Led Program in Rural Belize View Full Text Abstract Text Sarteneja is a rural coastal community in northern Belize with historically limited access to consistent medical care. Until recently, the village lacked a permanent physician, and residents relied on intermittent outreach clinics or travel to access services. Although infrastructure improvements have reduced travel times, accessing routine care requires a full-day commitment. A community-led diabetes support program utilizing lay community health workers (CHWs) was established to provide ongoing education and monitoring within the village. As part of enrollment, we characterized baseline clinical status and care gaps among participating adults to guide targeted CHW support strategies. To characterize baseline clinical status, behavioral patterns, and self-efficacy among adults with diabetes enrolling in a community-led CHW initiative to inform targeted education and support. We conducted a community-based descriptive analysis of adults with type 2 diabetes enrolling in a layperson CHW support program in Sarteneja, Belize. At enrollment, participants underwent anthropometric assessment, blood pressure measurement, point-of-care glucose testing, and HbA1c evaluation. A structured survey assessed demographics, medication use, healthcare access, self-management behaviors, and diabetes-related self-efficacy. Participants reported high medication adherence (mean 6.3 days/week; 79.7% reporting daily use); however, 27.5% of daily users remained poorly controlled (HbA1c ≥9%). Behavioral and knowledge gaps were evident: 26.6% reported forgetting medications, 28.1% reported no weekly exercise, and 38.1% did not report regular home glucose monitoring. Notably, 93.8% were unable to identify their A1c goal. Over half (54.7%) reported managing diabetes without support from family or peers. Adults enrolling in this community-based diabetes support program demonstrated substantial cardiometabolic burden alongside behavioral, educational, and self-efficacy gaps despite widespread medication use. Community-based models emphasizing sustained engagement and patient empowerment may strengthen chronic disease self-management in rural settings.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Stanton, Reagan	Tahani, Mehrnoosh	New Eyes for a Unique Telescope: Adding Circular Polarization to Dragonfly View Full Text Abstract Text Measurements of circular polarization, or the 3D oscillation of a component of light in a circular pattern, especially in optical wavelengths, are extremely challenging to observe and are therefore neglected in most astrophysical studies. However, existing observations and theoretical predictions have shown that we can expect regions with high circular polarization, especially near star-forming regions. Observing circular polarization is important for unraveling pivotal questions about the universe such as the presence of dark (non-luminous) matter, the origin of life (through understanding homochiral molecules), star formation, and beyond. We are designing an instrument that can measure circular polarization with the Dragonfly Telephoto Array, a novel and innovative telescope located in Mayhill, New Mexico. The Dragonfly Telephoto Array is an optical refracting telescope made out of 48 science-grade commercial camera lenses. This modular design gives the telescope the unique ability to probe both low brightness objects and complete polarization information of cosmic light throughout the universe at a high resolution. Currently, we are testing two possible designs for the circular polarization instrument. One design relies solely on the individual rotating polarizers on the cameras and the other design relies on the inherent properties of the Dragonfly Telephoto Array and uses the multicamera design to host various polarizing filter angles. Both designs will incorporate other optical components in addition to the polarizers. Our anticipated results are a conclusion about which design is more efficient and effective at measuring circular polarization as well as a plan to implement the instrument onto the telescope. This integration will open unique pathways for discoveries about the mysteries of the universe.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Hassouneh, Jana	Banerjee, Meeta	Zip Code and Opportunity: Examining Structural Disparities Across U.S. Zip Codes View Full Text Abstract Text This study examines whether structural disparities exist across the zip codes of college students in the United States, with a particular focus on differences in racial composition, homelessness rates, and food insecurity. The purpose of this research is to understand how geographic location may shape students’ lived experiences and access to social and economic resources. By identifying patterns of inequality across zip codes, the study seeks to determine whether certain communities experience concentrated disadvantage and how these structural factors may contribute to unequal conditions. The study hypothesizes that significant structural disparities will be present across regions of the United States, particularly in Southern states and urban areas, and that these disparities will be associated with differences in race, homelessness, and food insecurity. These conditions may influence students’ educational outcomes, safety, and overall well-being. The participants include 439 college students from the University of South Carolina, with data collected between 2022 and 2024. Future analyses will examine relationships between students’ demographic characteristics and the structural conditions of their home zip codes. Understanding these disparities may help educators and policymakers design targeted interventions to better support students from structurally disadvantaged communities.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Incognito, Isabella	Shustova, Natalia B. Maldeni Kankanamalage, Buddhima K. P.	Mapping of Catalyst Distribution in Porous Supports via Energy Transfer View Full Text Abstract Text Solid-supported (heterogeneous) catalysts play a pivotal role in the chemical and pharmaceutical industries due to their recyclability and resilience against contaminants. Therefore, it contributes significantly to sustainable chemical industry and align with green chemistry principles. One strategy to obtain highly efficient and industrially competitive heterogeneous catalysts is to encapsulate homogeneous molecular catalysts in a solid-state host-guest system. This approach combines the high activity and selectivity of molecular catalysts with the durability and recoverability of heterogeneous supports. Metal-organic frameworks (MOFs) have gained attention in this area as hosts due to their modularity, versatile pathways for catalytic site integration, and selective pore size capabilities. In this study, we demonstrated how resonance energy transfer (RET) can be used as a powerful method for mapping the evolution of catalytically active sites in host-guest catalytic systems. This presentation shows the synthesis of MOFs, their structural characterization, the integration of catalysts into MOFs with increasing pore sizes, and the study of different catalyst distributions in these host-guest systems using fluorescence spectroscopy via RET. Overall, this work showcases a novel concept acquiring the fundamental knowledge for mapping the catalyst distribution within a porous host, allowing us to develop next-generation solid-supported catalytic systems with enhanced catalytic activities.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Madiot, Gwenael	Schools, Gary Mengqian, Chen	Assessing the Process by Which a CDK8 Inhibitor Prevents Resistance to Palbociclib in MCF7 Cells View Full Text Abstract Text Hormone receptor-positive (HR+) breast cancer is commonly treated with targeted therapies such as Palbociclib, a CDK4/6 inhibitor that induces cell cycle arrest and apoptosis. However, resistance to Palbociclib remains a significant clinical challenge. CDK8 and CDK19, Mediator Complex kinases, regulate gene expression changes associated with drug resistance, including the activation of STAT1 and STAT3 transcription factors. Inhibition of CDK8/19 has been shown to prevent resistance to HER2-targeting and triple-negative breast cancer therapies, suggesting a potential role in maintaining Palbociclib sensitivity in HR+ breast cancer. The study aims to investigate the role of CDK8/19 inhibition in preventing Palbociclib resistance in HR+ breast cancer using MCF-7 cell xenografts, a well-established model for studying estrogen receptor-positive tumors. The hypothesis is the combination of Palbociclib and the CDK8/19 inhibitor SNX631 will prevent the development of resistance in part by limiting the phosphorylation of STAT1/3, therefore avoiding gene expression changes required for resistance. The project first quantified Ki-67, a marker for cell division, of 4 different treatment groups (control, Palbociclib, SNX631, and Palbociclib + SNX631) through immunofluorescence staining. The result showed a significant decrease in Ki-67 between Palbociclib alone and Palbociclib + SNX631 groups. The results involving apoptosis, which was quantified through immunofluorescence of Cleaved Caspase 3, and pSTAT1 yielded no significant differences between the treatment groups. The analysis of the mean intensity of pSTAT3 and STAT3 using immunofluorescence is still ongoing. This experiment demonstrated that adding a CDK8/19 inhibitor alters the proportion of proliferating cells in tumors treated with palbociclib. In contrast, neither the fraction of apoptotic cells nor changes in STAT1 protein expression and phosphorylation levels appear to contribute to the mechanism underlying the in vivo enhancement of CDK4/6 therapy by Mediator kinase inhibition. Further understanding of those pathways may allow for a greater remission percentage in patients with HR+ breast cancer.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Little, Wade	Wuesst, Thorsten Khan, Md Irfan	Blockchain Enabled Privacy-Preserving Cross-Industrial Data Collaboration in Smart Manufacturing View Full Text Abstract Text The increasing digitalization of manufacturing systems has led to the generation of vast amounts of data. However, ensuring the integrity, security, and intelligent utilization of this data remains a major challenge. This study presents an integrated framework that combines blockchain-based data storage with Machine Learning (ML) analytics to ensure a secure, scalable, and intelligent data management system. To protect the confidentiality and integrity of stored data, symmetric encryption (Advanced Encryption Standard, AES), asymmetric encryption (Rivest–Shamir–Adleman, RSA) and a hybrid (AES+RSA) encryption method are employed and comparatively analyzed. A chatter classification model was developed to detect and classify chatter conditions in a machining process dataset. The proposed framework was evaluated by analyzing different encryption mechanisms for blockchain based storage and assessing ML models under batch and incremental settings. For data protection, the hybrid approach shows optimal performance, maintaining minimal storage overhead (~0.8% higher than AES) and reduced computational complexity compared to RSA. For chatter classification, under the batch setting, four models; Logistic regression (LR), Random Forest (RF), Extreme Gradient Boosting (XGBoost), and Multi-Layer Perceptron (MLP) were implemented. Among them XGBoost achieved the best performance, attaining an accuracy of ~94.0%. In the incremental setting, the Hoeffding Adaptive Tree (HAT) classifier achieved accuracy around 90%. The integrated blockchain-ML framework provides a robust foundation for secure and intelligent manufacturing data management, facilitating real-time analytics and trustworthy decision making in smart manufacturing systems.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Southworth, Riwin Lee, Isabella	Burke, Fernanda	Unveiling Gut Health through VOC Analysis View Full Text Abstract Text Probiotics are beneficial microorganisms that play an essential role in supporting human health by enriching the gut microbiota and promoting immune function. These organisms naturally occur in certain foods and supplements as they contribute to overall well being through their metabolic activities. One key metabolic pathway is anaerobic fermentation, during which probiotics generate a variety of volatile organic compounds (VOCs) including carbon dioxide, low molecular weight alcohols, dimethyl disulfide, and benzaldehyde. Because these compounds provide insight into microbial metabolism, they can be quantitatively and qualitatively assessed using Gas Chromatography–Mass Spectrometry (GC MS). In this method, VOCs collected via Solid Phase Microextraction (SPME) fibers are separated according to their physical and chemical properties, then further identified based on retention time and mass spectra. This study investigates the VOC profiles produced by three prominent probiotic species: Lactobacillus casei, Lactococcus lactis, and Enterococcus faecium. Our research aims to characterize the types and relative quantities of chemical compounds released during fermentation by each organism and to evaluate the suitability of GC MS for detecting these metabolites. Preliminary data show the presence of three main alcohols across the species evaluated in our study. Of particular interest is 3 methyl 1 butanol, which is present at a significantly higher level than all other volatile components. This finding will allow for narrowing the scope of compounds and enable focused comparison of additional species with probiotic potential.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Tsomos, Angeliki	Kiaris, Hippokratis	Phenotype Development in Aging Colony of Peromyscus maniculatus (BW) View Full Text Abstract Text The Peromyscus Genetic Stock Center (PGSC) of the University of South Carolina maintains different stocks of deer mice (genus Peromyscus) as closed outbred colonies for several decades. Peromyscus are commonly studied model organisms in the field of biological and biomedical research, but systematic research on their aging -related phenotypes has not been performed as yet. A cohort of BW mice was longitudinally studied at the University of South Carolina, to record the phenotypes they develop as they age. Three common phenotypes started developing in older animals, being skin tumors, tail cricks, and ataxia. In this study we determined the incidence of these in relation to age, sex, and parental relatedness. The results show that crick tails develop with high correlation to tumors and may exhibit X-linked inheritance patterns. Tumor histology revealed squamous cell carcinoma pathology that develop around and after 2 years of age. The pattern of ataxia is significantly higher in male BW than females and coincided with inflammation of the liver. These phenotypic changes are associated with high age and parental relatedness, and high relatedness has lower chances of survival. The implication of this research helps scientists know about Peromyscus phenotypes, lifespan, and any confounding variables that may impact future investigations.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Lamendola, Andrew	Dudycha, Jeff	Linking Maternal Diet to Offspring Lipid Stores: Transgenerational Effects of Food Environment in Daphnia View Full Text Abstract Text Maternal effects, defined as the influence of a mother’s environment and physiology on the phenotype of her offspring, are a central topic in evolutionary ecology. Daphnia, a small freshwater crustacean, has been a model for investigating maternal provisioning and resource allocation. Previous work demonstrates that maternal food conditions strongly affect offspring quality: mothers in low-food environments typically produce fewer but larger, lipid-rich eggs, enhancing neonate starvation resistance, while offspring reared under poor food conditions grow slower but can be partially buffered by maternal provisioning. Despite decades of research on high versus low food environments, no studies have explicitly tested whether maternal or offspring environment plays the stronger role in shaping lipid provisioning. This project provides a direct comparison of maternal versus offspring food environment effects on lipid content, while also testing how ecological background shapes these transgenerational dynamics. Pond (Daphnia pulex) and lake (Daphnia pulicaria) populations differ in life-history strategies, with pond populations typically exhibiting “faster” strategies and lake populations “slower” strategies, making them an ideal system for comparison. Using a 2 × 2 factorial design (maternal high vs. low food × offspring high vs. low food) in both species, lipid allocation was quantified using Nile Red fluorescence microscopy. Measurements were made after the third clutch to ensure representative adult reproductive investment. Body length and clutch size were also measured. I hypothesized that maternal diet will have a stronger effect than offspring diet on lipid storage in adult offspring, and that pond and lake species will differ in the magnitude of maternal influence.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Haynes, Madelyn	Roberts, Jane Hantman, Rachel	Parental Stress Levels in Parents of Children with ASD and ASIBs View Full Text Abstract Text Autism spectrum disorder (ASD) is a neurodevelopmental disorder involving challenges with social interaction and communication, deficits in relationship skills, and repetitive or restrictive behaviors (American Psychiatric Association, 2013). A child has an elevated risk of developing ASD if they have an older sibling diagnosed with ASD (Britsch and Iverson, 2025). Parental stress results from caring for a child while parenting demands outpace resources (Abidin, 1992). Studies report parental stress levels are higher in parents of children with ASD than in parents of neurotypical children (Pastor-Cerezuela et al., 2016); however, the relationship between parents’ stress regarding their child with ASD and their younger siblings (ASIBs) is understudied. Filling this gap will further knowledge into ASIBs and how parents’ stress is impacted by this population. Using the Parental Stress Index (PSI-SF; Abidin, 1995) to measure parents’ stress levels, an independent t-test was completed to identify the difference between stress in parents of children with ASD compared to ASIBs. It was hypothesized that parental stress levels would be lower for ASIBs than for children with ASD. Participants included mothers of 82 toddlers: 60 (85% males, mean age 3.78 years) diagnosed with ASD and 22 (54.55% males, mean age 3.53 years) ASIBs. The results indicated higher levels of stress in parents of children with ASD than in parents of ASIBs (t(80) = 3.881, p < .001). This may be because ASIBs have less severe symptoms of ASD than their older siblings or because parents experience more self-efficacy with their second child (Pisula and Ziegart-Sadowska, 2015; Vanaken et al., 2024). These results will help first-time parents of toddlers by offering appropriate resources and will help parents earlier in their child’s life, reducing stress that would otherwise persist. Future research could evaluate role of sibling order or compare the parental stress of ASIBs to neurotypical children.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Gazzelli, Elenora	Young, Sarah	The Effect of Recent Military Policy Shifts on Public Service Motivation of ROTC Cadets and College-Enrolled Service Members View Full Text Abstract Text Our study explores public service motivation in ROTC cadets and college-enrolled service members. The public service motivation (PSM) scholarship emphasizes how public sector workers are drawn to careers due to intrinsic incentives (qualities internal to the job itself) even more than extrinsic incentives (externally provided compensation such as pay or benefits). Our study considers how public service motivation of students pursuing military careers may be impacted by current military policy changes. Our hypothesis is that respondents indicating higher levels of PSM in their reasons to pursue military service will report feeling more negatively impacted due to these policy shifts than those who indicate less PSM. We operationalize negative impact as respondents expressing decreased confidence, pride, and/or motivation to pursue a military career within the past year. We will administer an anonymous online survey utilizing a widely-respected measure of PSM (see Kim et al 2013) to the military population on the USC Aiken campus. The study will add to the literature on PSM by considering how policy shifts in deployment, funding, and public perception of military service impact service members’ and recruits’ incentivization experiences. We will also add to the body of data-informed PSM studies that emphasize college service members as a particular population of interest. Survey administration is ongoing and results are forthcoming.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Kohlmann, Samantha	Outten, F. Wayne Miller, Kennedy	Functional Characterization of Iron-Sulfur Cluster Binding in the E. coli Ferric Uptake Regulator (Fur) View Full Text Abstract Text Iron is an essential cofactor required for central metabolic and redox processes, including respiration, DNA synthesis, and iron–sulfur (Fe–S) cluster biogenesis. In Escherichia coli, intracellular iron must be tightly regulated to support Fe–S cluster assembly while preventing oxidative stress caused by excess free iron. Iron homeostasis is controlled in part by the ferric uptake regulatory protein (Fur), a metal-dependent transcription factor that coordinates expression of genes involved in iron acquisition, storage, and utilization. While Fur has classically been described as an iron-activated DNA-binding repressor, prior work has demonstrated that it can also bind an Fe–S cluster, suggesting a potential link between Fe–S cluster status and transcriptional regulation. This project investigates the mechanism by which Fur acquires its Fe–S cluster in vitro and evaluates whether cluster delivery occurs via known Fe–S trafficking proteins, including the monothiol glutaredoxin, GrxD, and the A-type carriers. To investigate this, Fur is overexpressed and purified for anaerobic biochemical reconstitution and spectroscopic analysis. Iron–sulfur cluster formation and associated changes in protein properties are monitored using circular dichroism and UV–Visible Absorption Spectroscopy to detect characteristic Fe–S spectral features. Ongoing studies assess cluster transfer reactions between Fur and candidate trafficking proteins in vitro. This work seeks to clarify how iron sensing is integrated with Fe–S cluster biogenesis and trafficking, ultimately refining current models of bacterial iron homeostasis and redox-responsive transcriptional control.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Parise, Sanjana	Patel, Rekha Swager, Emily	Role of PKR in Regulating the Integrated Stress Response (ISR) During Endoplasmic Reticulum (ER) Stress View Full Text Abstract Text Many neurodegenerative diseases, including some forms of dystonia, Parkinson’s, Alzheimer’s, and Huntington’s diseases, involve chronic endoplasmic reticulum (ER) stress, which is a critical component of disease progression. Disruption in ER homeostasis is regulated through the Integrated Stress Response (ISR), an evolutionarily conserved pathway activated in eukaryotic cells. The core event of this pathway is the phosphorylation of eIF2α, a critical translation initiation factor. Phosphorylation of eIF2α attenuates general protein synthesis while allowing selective translation of stress response proteins. These proteins promote either recovery and homeostasis or cellular apoptosis (programmed cell death), depending on the intensity and duration of the stress signals. One of the kinases that initiates this core event is PKR, which is traditionally defined as a viral response protein and can be activated by directly binding dsRNA or by binding to its upstream activator protein PACT. Our lab has shown that PKR is activated by PACT under ER stress conditions, directly linking PKR to cellular fate decisions under ER stress. To examine the contribution of PKR to the restoration of homeostasis through the ISR, this experiment utilized a human neuroblastoma cell line SK-N-SH, which has been stably transfected with a plasmid containing a puromycin selection marker and a catalytically inactive mutant of PKR, known as K296R. K296R forms homodimers with the endogenous wild-type PKR expressed in cells, leading to PKR inhibition. After treating the cells with tunicamycin, an ER stress-inducing drug, I examined how catalytically inactive PKR affects eIF2α phosphorylation and downstream ISR signaling. I hypothesized that the absence of PKR would compromise the ISR, resulting in delayed or reduced p-eIF2α, ATF4, and CHOP expression. Understanding this pathway provides key insights into the molecular causes of cell death in neurodegenerative diseases and supports new therapeutic approaches.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Bradbury, Alexia	Vannucci, Aaron Maybach, Laura	Electronic State and Selectivity Relationships of a New Class of Hybrid Catalysts on Metal Oxide Supports View Full Text Abstract Text Heterogenous catalysts are currently utilized because of their long catalyst lifetimes and ease in separation. Homogeneous molecular catalysts are used because of their unmatched product selectivity. Hybrid catalysts take the benefits of both types by anchoring molecular catalysts onto heterogeneous supports. Second row transition metals, though rare and expensive, are currently used within these catalysts for their strong stability and selectivity. To make these catalysts more accessible, their first-row transition metal counterparts should be used instead, for sustainability and costs sake. First row transition metals are not used often though because they tend to be too unpredictable, which leads to short catalyst lifetimes. Thus, new strategies are needed to correct this problem and enable their use in a specified manner. We have developed a new procedure for anchoring molecular catalysts to oxide supports through metal-ester bonds and this new anchoring influences the reactivity of the hybrid catalysts. This linkage also prevents many decomposition routes, most notably dimerization. Thus, a first-row transition metal can be a replacement for the second-row transition metals with the right procedure. Initially, a nickel catalyst, instead of a second-row palladium catalyst, was utilized for Suzuki-Miyaura cross-coupling reactions, and the conditions were optimized to achieve the highest percent yield. Following this, a manganese catalyst for CO, reduction was developed to replace expensive rhenium catalysts, and IR characterization of the carbonyl ligands allowed us to measure changes in metal center electron density, thus changing the selectivity of the catalyst. In the end, we achieved a new understanding of the electronic state and the specificity relationship of molecular catalysts on metal oxide supports through a metal-oxide-ester binding motif.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Moser, Ryan	Heyden, Andreas Zare, Mehdi	Developing a Machine Learning Potential for Catalyst Discovery in the Liquid Phase View Full Text Abstract Text Accurately modeling catalytic behavior under realistic liquid-phase conditions is essential for understanding a wide range of chemical reactions; however, traditional computational methods achieve this precision only at computational costs that are currently infeasible. Current methods face a fundamental trade-off. Approaches such as density functional theory (DFT) struggle to model large-scale systems over long timescales, while classical molecular dynamics methods based on force fields efficiently reach long timescales but often fail to accurately predict key energetic quantities, such as adsorption energies and activation barriers. This project develops machine learning potentials capable of efficiently modeling reactions at solid-liquid interfaces with accuracy comparable to that of DFT. The insights gained will establish a framework for extending high-fidelity modeling to complex, solvent-mediated catalytic systems that are currently beyond reach. To showcase the efficiency of this new methodology, an aqueous-phase alkoxy-hydrogenation reaction over Ru(0001) was used as a test case. This system demonstrates that the novel approach accurately captures the necessary physics of a complex, catalytic interface. Ultimately, this work will accelerate catalyst design and contribute to the advancement of sustainable and data-driven chemical technologies.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Powell, Austin	Moussa Rogers, Mary	Is Tobacco Free Really Tobacco Free? View Full Text Abstract Text Electronic cigarette (EC) use has steadily risen, bringing new psychological and social issues, specially creating challenges for policies. For example, recent standards suggest implementing a tobacco-free and smoke-free environment for workplaces and university campuses, with no updated language regarding nicotine free spaces as smokeless ability to enforce policies decrease. Along with EC use rising, new trends in nicotine pouch (NP) consumption begun around 2020 in the United States. Both ECs and NPs make stealth use more possible compared to combustible cigarettes or dip, chew, and snus. With both ECs and NPs being flavored and more discrete than their tobacco counterparts, each are increasingly attractive to new demographics of nicotine consumers who perceive these products as more safe to use than their tobacco counterparts, which increases risk of mortality and morbidity rates in educational and work environments. With the lack of literature comparing nicotine use motivations and possible health outcomes across environments where smoke free or tobacco free policies are implemented, as well as across form of nicotine used it is increasingly important to understand the stealth use behaviors for early intervention and policy change in prohibited locations. This study aims to clarify the current trends in nicotine use across types in environments with tobacco-free or smoke-free policies. The project will gather information from past and present nicotine users through Prolific. Measures include questionnaires assessing nicotine use frequency and motives, perceptions of policy and use in workplace or school environments, and demographics. For analyses, total scores of each measure will be created by summing or averaging items. Frequencies and descriptive statistics will be examined to evaluate use types across prohibited locations. Chi-square analyses will be conducted via SPSS to examine if there are significant differences across types of nicotine use and location of prohibited use.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Webb, Emily	Fillo, Jennifer	Social resources as protective factors against alcohol misuse among adults in the US, 2024 View Full Text Abstract Text Alcohol use disorder (AUD) is the most common substance use disorder in the US, yet only ~5% of those with AUD receive treatment annually. Research shows that social/interpersonal factors (e.g., family/romantic relationships) can mitigate alcohol misuse and encourage treatment; however, substance use treatments remain largely individual-focused, and recent population-level research examining these effects remains sparse. This study examined relations between social resources and alcohol use patterns in a nationally representative sample. Using data from the 2024 National Survey on Drug Use and Health (most recent publicly available wave; n=24,068), analyses tested differences in alcohol variables (past month: any use, quantity, frequency, binge, heavy drinking, AUD) by marital status (never/previous/current), children in the home (none/any), and living situation (alone/with others), controlling for sex and age. Weighted regression models accounted for complex sampling. Currently (vs. never) married individuals were 34% more likely to drink, consumed 23% fewer drinks per occasion, had 23% lower odds of binge drinking, 26% lower odds of heavy drinking, and 20% lower odds of meeting AUD criteria. Those with children in the home (vs. none) were 24% less likely to drink, had 12% lower drinking frequency, and 21% lower odds of meeting AUD criteria. Living with others was associated with 9% lower drinking frequency, but 12% higher odds of binge drinking. Results show that family-level social resources may protect against alcohol misuse/AUD. Children in the home was related to drinking less often and lower odds of AUD. Whereas marriage was associated with greater likelihood of any drinking, it also appears to protect individuals from more hazardous drinking patterns and AUD. This same protective effect was not observed for the presence of others in the home, generally. These population-level findings demonstrate the protective role of social resources and bolster arguments for greater inclusion of close others in alcohol-related interventions.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Zabielaite, Meda	Xu, Peisheng	PDA-PEG/Copper Selective Killing of Ovarian Cancer Cells View Full Text Abstract Text Ovarian cancer remains a leading cause of gynecologic cancer mortality due to late-stage diagnosis and limited therapeutic selectivity. Epithelial ovarian cancers account for approximately 95% of all malignant ovarian tumors, indicating the need for highly targeted therapeutic methods with improved selectivity and systemic toxicity. This study evaluated the cytotoxic selectivity of poly[(2-(pyridin-2-yldisulfanyl) ethyl acetate)-co-[poly (ethylene glycol))]] (PDA-PEG) nanoparticles in combination with copper ions (PDA-PEG/Cu) on the epithelial-like SKOV3 ovarian cancer cell line. PDA-PEG polymer comprises hydrophobic PDA segments and hydrophilic PEG segments, allowing the formation of a polymer nanocomplex with copper ions in aqueous solution. Polymer nanoparticles were synthesized and characterized by dynamic light scattering. Cytotoxic effects of polymer and Polymer/Cu were assessed using MTT assays. Comparative analyses were conducted to determine whether copper supplement can enhance selective cytotoxicity relative to polymer alone. Results demonstrated that Polymer/Cu significantly increased the cytotoxicity of SKOV3 cells compared to the standalone polymer, without affecting normal cells. This indicates enhanced anticancer activity upon complex formation. These findings suggest that copper-mediated activation of the polymer may represent a promising strategy for the selective killing of ovarian cancer cells.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Leonard, Lilly	Flory, Kate Tucker, Aren	Grit as a Potential Moderator of the Association Between School Support and Internalizing Symptoms among College Students View Full Text Abstract Text College students are at heightened risk for internalizing symptoms, including depression, anxiety, and stress. Prior literature identifies school support as a robust protective factor, with higher levels of perceived school support associated with lower internalizing symptoms. School support is defined as a network of resources designed to foster a safe and supportive learning environment for students. This network of support encompasses multiple dimensions, including adult support, peer support, and school safety. Although school support has been linked to lower internalizing symptoms, its protective nature varies from person to person based on individual factors. Grit, defined as sustained passion for long-term goals, is one such individual factor that could impact the association between school support and internalizing symptoms. For instance, students high in grit may be better equipped to overcome emotional challenges even in the context of low perceived school support. No previous research has examined whether grit could moderate the relation between school support and internalizing symptoms, particularly among college students. This current study aims to address this gap by examining whether grit impacts the association between school support and depression and anxiety in college students. Participants were 2,066 undergraduate students (M age = 19.5; 71% female) across seven U.S. universities participating in the multisite Undergraduate Learning, Emotion, and Attention Research Network (U-LEARN) study. Of the sample, 353 participants identified as Hispanic, Latino, or of Spanish origin, and 1,713 identified as non-Hispanic. Regarding race, 66.4% identified as White, 24.8% as Asian, 8.2% as Black, 3.3% as Middle Eastern, 4.6% as Pacific Islander, 2.2% as Native American, and 0.8% identified with another racial background. Students were administered an online survey that included measures of grit, perceived school support, depression, and anxiety. Analyses will be run using multiple regression. Findings may support campus-based interventions designed to strengthen individual perseverance to complement institutional support to reduce internalizing symptoms among college students.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Mozeleski, Anne	Palomares, Melanie	Evaluating the Impact of Undergraduate TAs in Psychology View Full Text Abstract Text The Assistantship of Teaching in Psychology (AToP) is a service-learning class to explore the psychological science of teaching and learning, and to support students in large and challenging classes as undergraduate teaching assistants (UGTA). UGTAs hold tutoring and instructional sessions aligned to the lectures of their instructional mentor and their AToP seminar topics. Luckie et al. (2020) found that students who practice testing themselves with an UTA before an exam have enhanced performance on the exam in an Introduction to Cell and Molecular Biology class. The current study evaluated the impact on test scores in psychology classes. We analyzed test score differences for students who did and did not attend SE exam review sessions across different level psychology courses. Our hypothesis is that there will be an increase in test score for students who attend the UGTA exam review session and there will be a greater difference for Introduction to Psychology students compared to higher level psychology students. The role of student motivation and engagement will be discussed.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Castellanos, Isabella	Tan, Wenbin	The Role of NR2F2 in Regulation of Glutathione Synthesis and Acquisition of Laser Treatment Resistance in Capillary Malformations View Full Text Abstract Text Capillary malformations (CMs), also known as port wine birthmarks (PWBs), are a type of congenital vascular malformation characterized by flat red lesions, nodule formation, progressive vessel dilation, endothelial cell (EC) proliferation, and poor response to pulse dye laser (PDL) therapy, with approximately 20% of patients exhibiting treatment resistance. Prior studies using patient-derived induced pluripotent stem cell (iPSC) models demonstrate elevated glutathione (GSH) levels and upregulation of GSH-synthesis enzymes, suggesting that enhanced antioxidant capacity may contribute to laser-treatment resistance. However, the upstream regulatory mechanisms driving GSH upregulation remain unclear. This project investigates the novel role of nuclear receptor subfamily 2 group F member 2 (NR2F2), a master transcription factor involved in vascular development and endothelial-to-mesenchymal transition (EndMT), in regulating GSH synthesis and promoting laser resistance in CM endothelial cells. We hypothesize that NR2F2 upregulation increases expression of key GSH-related enzymes such as glutathione S-transferase Pi 1 (GSTP1), γ-glutamyl transferase 7 (GGT7), and glutamate cysteine ligase modulatory subunit (GCLM), leading to enhanced scavenging of laser induced reactive oxidative species and acquisition of a photodynamic therapy (PDT) resistant phenotype. Using CM and normal iPSCs integrated with a Tet-On inducible NR2F2 system, endothelial cells will be differentiated and assessed for GSH-enzyme expression via Western blotting. PDT with indocyanine green (ICG) and near-infrared laser (NIR) exposure will evaluate treatment resistance through quantitative cell viability analysis. We anticipate that NR2F2 overexpression will elevate GSH-associated enzymes and confer a PDT-resistant phenotype, identifying a previously unexplored molecular pathway linking NR2F2 to antioxidant regulation in CMs. These findings may reveal a novel therapeutic target to overcome laser resistance and improve clinical outcomes for pediatric patients with capillary malformations. Keywords: Capillary malformations; NR2F2; glutathione synthesis; photodynamic therapy; laser-treatment resistance; endothelial-to-mesenchymal transition.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Patton, Brady Wehmeir, Naomi	Meyer-Gutbrod, Erin Walsh, Ryan	Body condition of Pacific Coast Feeding Group gray whales from 2018 to 2019 in northwest Washington View Full Text Abstract Text Eastern North Pacific (ENP) gray whales (Eschrichtius robustus) are a population of gray whales that have faced recent declines in both total population and calf production. From 2019-2023, the ENP experienced an Unusual Mortality Event (UME) due to increased mortality and proportion of whales in poor condition. Within the ENP is a unique feeding group of gray whales, the Pacific Coast Feeding Group (PCFG), who feed off the coast of northern California to northern British Columbia during the summer. In this study, photos of PCFG gray whales were provided by the Makah Tribe to evaluate the body condition of this group during the feeding seasons of 2018 and 2019 to address how the UME may have impacted the PCFG. Individual whales photographed were identified and body condition was analyzed using an established protocol based on visual evaluation of three anatomical regions: the post-crania, scapula, and lateral flank. From these evaluations, individuals were assigned monthly body condition scores of poor, fair, or good. Repeated sightings of individuals were used to evaluate changes in body condition within and across seasons. This study provides important baseline information on seasonal body condition patterns in PCFG gray whales prior to and at the peak of the 2019-2023 Unusual Mortality Event. Furthermore, it contributes to a long-standing evaluation of body condition for PCFG gray whales in this region that dates back to 1996.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Wood, Julia	Fu, Xiaoxue Kong, Haiyan	The Impact of Anxiety on Executive Function in College Students View Full Text Abstract Text Executive functions (EFs) refer to the series of top-down cognitive processes that enable individuals to engage in the coordinated effort of behavior regulation and goal achievement, especially in novel or challenging situations. Working memory (WM) and inhibitory control (IC) are two distinct but interconnected components of EF. WM involves the ability to store and manipulate information over short periods of time. IC is the ability to inhibit an automatic or prepotent response to support goal-directed behavior. Mental health has significant impacts on EF, especially in college students that face increased vulnerability to internalizing disorders. Anxiety, characterized by persistent intrusive thoughts and concerns that result in perpetual worry and tension, is one internalizing disorder that can have bi-directional effects on EF. This study investigates the association between anxiety symptoms and EF performance, focusing on WM and IC, in college students. Participants aged 18- to 24-years (n=60) were recruited to complete a demographic questionnaire and the Beck Anxiety Inventory (BAI) to assess self-reported anxiety symptom severity, as well as computer tasks that measured components of EF. These participants completed the Color Change Detection (CCD) Task and the AX-Continuous Performance Task (AX-CPT) to provide measures of WM and IC, respectively. Performances were measured with accuracy and reaction time (RT) metrics to examine whether higher anxiety levels are associated with poorer performance on either or both EF tasks. Data analysis is in progress. It is hypothesized that there will be a moderate positive correlation between WM and IC measures, such that individuals who perform better on the CCD Task will also perform better on the AX-CPT Task. Additionally, higher levels of anxiety symptoms will be negatively associated with both WM and IC performance, with increased symptom severity predicting lower task accuracy and slower RTs.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Pitre, Michael	McQuail, Joseph Horovitz, David Sikora, Anna Tolaka, Iangel Wohlfeld, Christian Fadel, Jim	Dysregulation of D- and L-Serine Metabolism During Cognitive Aging View Full Text Abstract Text Aging is associated with impaired NMDA receptor signaling and cognitive decline. D-serine functions as a co-agonist at the NMDA receptor and is critical for hippocampal-dependent spatial learning. Prior transcriptomic analyses from our laboratory identified age-related changes in genes regulating D-serine synthesis (serine racemase; SRR) and the upstream L-serine biosynthetic pathway, including phosphoglycerate dehydrogenase (PHGDH) and phosphoserine aminotransferase (PSAT1). We therefore hypothesized that aging would alter protein expression of these enzymes and that enzyme levels would predict spatial learning performance. Young (4–8 months; n = 16) and aged (22–26 months; n = 33) Fischer 344 rats were tested in the Morris Water Maze, and a spatial learning index (SLI) was calculated from probe trials. SRR, PHGDH, and PSAT1 protein expression were quantified by Western blot in hippocampus and frontal cortex. Aged rats exhibited significantly higher SLI scores than young rats (p = .002), indicating impaired spatial learning. Hippocampal SRR expression was reduced with age. In regression models predicting SLI while controlling for age and sex, SRR did not independently predict performance; however, inclusion of an SRR × age group interaction improved model fit (R² = .287, p = .004), and the interaction term approached significance (p = .065), suggesting age-dependent differences in the association between SRR expression and spatial learning. In the frontal cortex, PHGDH and PSAT1 were significantly upregulated with age, although neither predicted SLI. These findings demonstrate coordinated, region-specific alterations in D- and L-serine metabolic enzymes during aging. While protein expression did not uniformly predict behavioral performance, such age-related shifts and preliminary evidence of age-dependent enzyme–behavior coupling support further investigation of serine metabolism as a contributor to cognitive aging. Ongoing work using the same aging and behavioral framework will quantify D-serine, L-serine, and glutamate levels to determine whether metabolite availability more directly relates to spatial learning.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Daino, Madelyn	Warren, Karen Dawson, Robin	Small Patients, Big Effects: NICU’s Impact on Healthy Siblings View Full Text Abstract Text This study uses a multi methods approach to explore the experiences of young adults who had a sibling in the Neonatal Intensive Care Unit (NICU), to examine potential psychological distress, connections to parentification, and to identify other shared lived experiences amongst this population. Current NICU research often overlooks the experiences of the siblings of NICU patients, despite the possible effects of this experience. Early exposure to a traumatic event, coupled with limited parental support and the assumption of adult roles during one’s formative years, may contribute to lasting psychological and emotional impacts. This study is grounded in Dr. Minuchin’s family systems theory, which links the behavior of one family member to the dynamics of the entire family. An explanatory sequential mixed methods design was used, combining surveys and interviews to explore the experiences of young adults who had a sibling in the NICU. Three surveys were utilized: the Parentification Scale, the Beck Anxiety Inventory, and the Posttraumatic Growth Inventory. Survey results informed the development of an interview guide, which was used for a focus group of five NICU siblings and one individual interview. Quantitative analysis shows that those with siblings in the NICU scored higher on the Parentification Scale and Beck Anxiety Inventory compared to those with healthy or no siblings. They also reported elevated scores on the Posttraumatic Growth Inventory. Interview themes included shifts in family roles, heightened anxiety, limited access to information, altered perceptions of the healthcare setting, and increased appreciation/personal growth. Data integration showed possible relationships between access to information during the hospitalization and anxiety and showed potential role of visitation and healthcare professionals in shaping sibling experiences. Further research is needed to deepen the understanding of this experience and to develop strategies to mitigate the negative outcomes for this population.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Martillotti, Ashley	Dudycha, Jeffery Bruner, Matthew Anderson, Adrian	Effect of Light Spectrum on Resource Allocation and Reproductive Fitness in Daphnia pulex. View Full Text Abstract Text Environmental light conditions play a significant role in organisms' physical development and reproductive patterns, especially in species where visual cues shape their behavior. This is known mostly from experiments that manipulate light intensity, but there is limited research done with respect to light spectrum. Daphnia have a single compound eye and use opsins, which are light sensitive proteins, to mediate light perception within their environment. Daphnia pulex contain a notably larger number of red opsins, compared to blue light opsins. This study was designed to determine whether this disparity influences fecundity and morphological composition in Daphnia, when they are exposed to different light wavelengths. Three light environments were designed to examine the potential response: a blue light, red light, and a broad light environment that served as a control. The project was focused on determining if light wavelength, and corresponding opsins in Daphnia, would impact resource allocation and reproductive fitness. Two clones were used in the experiment, KAP-100 and SKC-1, to test the interaction of light environments with genotype. Reproductive fitness was measured via a daily data collection of offspring produced per organism, from maturity through third clutch. Individuals were also photographed at maturity, and again at third clutch to measure eye size and body size. These two measurements would reveal if the energy investment in sensory structures differed between light environments and age. Factorial Analyses of Variance were conducted to test for the effects of light environment, genotype, and their interaction on fitness and morphology. These tests were done with respect to maturity and 3rd clutch to account for changes in age. Results indicated that light environment had a mostly weak, but detectable effect influencing reproductive fitness at first clutch and not third clutch. Light spectrum also influenced eye size, but in a genotype dependent manner.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Sutherland, Isabelle	Hudac, Caitlin McFadden, Jackson Mace, Olivia Benjamin, Sophie C. Nelson, Cailee	The Association Between Repetitive Behaviors and Social Responsiveness in Autistic Individuals View Full Text Abstract Text Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by restricted and repetitive behaviors and difficulties in social communication. Repetitive behaviors, sometimes observed as motor behaviors commonly known as stimming, may be used by autistic individuals as a means of self-regulation in response to emotional or sensory stimuli (Caldwell-Harris, 2021). Social challenges, including difficulties interpreting social cues, maintaining reciprocal conversations, and forming relationships are among the most prominent features of ASD and can significantly impact daily functioning (Hodis et al., 2025). Because repetitive behaviors and social impairments are core features of ASD, they co-occur, and a better understanding of how these two symptom domains are related could help develop more effective interventions that recognize repetitive behaviors as functional coping mechanisms rather than behaviors that should be suppressed, while also increasing awareness of stimming and reducing the social stigma and ostracization experienced by autistic individuals. The objective of this study was to examine the association between repetitive behaviors and social responsiveness in autistic adolescents. It was hypothesized that higher levels of repetitive behaviors would be associated with greater impairment in social responsiveness. Repetitive behaviors were measured using the parent-reported Repetitive Behavior Scale (RBS), and social responsiveness was assessed using the Social Responsiveness Scale (SRS) T-scores, with higher scores indicating more social problems (Constantino, 2013). Data were collected from 14 autistic participants (9 males, 5 females) aged 8–17 years. A linear regression analysis was conducted to investigate the relationship between repetitive behaviors and social responsiveness. Results showed a significant positive relationship between the two variables such that higher RBS scores (i.e., more repetitive behavior problems) were associated with higher SRS T-scores (i.e., greater social impairment) (R² =.58, p = .001). These findings suggest that higher levels of repetitive behaviors are associated with increased social difficulties in autistic youth.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Rucker, Caroline	Peryshkov, Dmitry Tellier, Gabby	Synthesis of Tetrazine Phosphines for Metal-Free Catalysis View Full Text Abstract Text Many important pharmaceuticals and industrial products are synthesized using precious metal catalysts, which accelerate chemical reactions without being consumed in the process. Although these catalysts are efficient, they are rare, expensive, and often toxic. Developing sustainable, metal-free alternatives is therefore a significant goal in modern chemistry. Work in the Peryshkov Group at the University of South Carolina explores tetrazine phosphines as a potential platform for metal-free catalysis. Phosphorus can exhibit metal-like reactivity by cycling through its available oxidation states enabling electron transfer and potential bond activation. Additionally, tetrazine, the nitrogen containing analogue of benzene, is efficient at mediating reversible electrons and proton transfer. By integrating these two components, this system aims to cooperatively drive key chemical transformations without relying on precious metals. This project focuses on developing the foundational starting materials necessary to access tetrazine phosphines, supporting ongoing efforts toward sustainable catalytic design.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Hughey, Aryana	Banerjee, Meeta	Exploring the Impact of Trauma and Racial Discrimination Among University Students View Full Text Abstract Text As access to higher education expands among marginalized groups, it is critical to examine the psychological factors that influence academic success (Jones et al., 2023). Mental health plays a significant role in shaping academic outcomes and student behavior, and frequent experiences of racism and discrimination have been linked to depression, stress, anxiety, and self-harming behaviors (Valentine et al., 2025). However, the relationship between post-traumatic stress disorder (PTSD) resulting from racial discrimination and students’ attitudes toward education remains underexplored. Experiences of racial trauma may shape how minoritized students perceive themselves within academic environments, interact with educators, and engage in their educational pursuits (Kirkinis et al., 2021). The present study examines how memories of racial discrimination during high school are associated with self-reported post-traumatic stress symptoms. We hypothesize that specific types of racial discrimination will be associated with greater trauma-related symptoms. Additionally, this study investigates the extent to which trauma influences academic self-concept and self-esteem among college students. Data were drawn from a larger study known as the Neighborhood Safety and Well-Being Study conducted in Southern California. The sample includes 892 college students identifying as African American (8%), Latinx (86%), or Multiracial (6%). From the sample, 73% of participants identify as female, and 51% reported being first-year students. Participants reported post-traumatic stress symptoms, past and current racial discrimination, academic self-concept, and academic performance. Preliminary findings indicate that racial discrimination experiences, past and present, are associated with reports of trauma. Additionally, reports of greater racial discrimination during high school were linked to poorer academic self concept, but greater racial discrimination was positively related to academic engagement. Findings from this study aim to inform trauma-informed and equitable educational practices that better support students from diverse backgrounds.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
de Luca, Summer	Krizek, Beth	Transcription Factors: Key Regulators of Floral Organogenesis in Arabidopsis thaliana View Full Text Abstract Text GROWTH REGULATING FACTORS (GRF) in plants are transcription factors that promote organ growth. Understanding these growth pathways would be crucial in agricultural settings and could allow for intentional manipulation of plants, such as increasing crop yield or size. In the plant Arabadopsis thaliana, a family of nine GRFs exhibit genetic redundancy with overlapping functions in the regulation of leaf size. GRF6 is most closely related to GRF5 but no mutant phenotype has been characterized. We have obtained newly generated CRISPR alleles of grf1,2,3,5,6 and have crossed grf6 with each of these mutants. Double mutants were identified by PCR amplification, restriction enzyme digestion, and gel electrophoresis. Preliminary analyses suggest the grf6 double mutants show no strong defects in organ size. Leaf and petal size measurements of the double mutants will be presented. It may be necessary to make higher order mutants, such as triples or quadruples, in order to produce more severe phenotypes.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Catapano, Allison Vallabhaneni, Neha	Roberts, Jane	Longitudinal Language Development Differences Between Children with FXpm and their NT Peers View Full Text Abstract Text Early vocal behaviors and caregiver-child interactions are well established predictors of later language development in neurotypical (NT) populations; however, less is known about how these early markers function in infants with the fragile X premutation (FXpm). FXpm results from a CGG repeat expansion in the FMR1 gene of the X chromosome and may have co-occurring social communication delays, autism spectrum disorder, and social anxiety (Tassanakijpanich et al., 2021). With deficiencies in language acquisition for this genetic group, it is important to assess early indicators of such delays for proper intervention. This study examines whether infant vocal behaviors and caregiver interactions predict language outcomes at 24 months in children with FXpm compared to NT peers. The experimental group included 19 participants with FXpm and the control group included 14 NT participants, both assessed at infancy (FXpm: Mage=11.74 months; NT: Mage=12.48 months) and around 24 months (FXpm: Mage=24.38 months; NT: Mage=24.21 months). Early vocal behaviors were measured during infancy using the Language ENvironment Analysis (LENA) system, a validated automated tool that captures standardized scores for conversational turns (verbal exchanges between adult and child), child vocalizations (utterances from the participant), and vocal productivity (quality of the child utterances based on consonant and vowel pairings) from recordings of interactions occurring in their natural daily environments (Gilkerson et al., 2017). The Bayley Scales of Infant and Toddler Development (BSID-4) assessed language at 24 months, with expressive and receptive communication scores serving as primary outcome measures (Balasundaram & Avulakunta, 2022). Regression analyses will examine if infant LENA measures predicted 24-month language outcomes and the association differences between FXpm and NT groups. We hypothesize that FXpm children will show lower BSID-4 language scores at 24 months and weaker predictive associations between infant LENA measures and 24-month language outcomes than NT peers.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Smerczynski, Eve	Stone, Joshua	Four decades of change in the copepod community of North Inlet Estuary, SC View Full Text Abstract Text Copepods play an essential role in estuarine food webs, providing a major food source to many organisms that thrive there. Thus, any responses of the copepod community to long-term changes in the environment are likely to cascade throughout the pelagic food web. This project aims to answer two main questions: Has the copepod populations in North Inlet Estuary changed over the past 43 years, and if so, can these changes be linked to known climate related variables such as temperature and salinity? To answer these questions, biweekly samples from the North Inlet Estuary Zooplankton Time Series (1980-2024) are being used to quantify copepod community composition and investigate any possible shifts in their populations over the past four decades. Sample analysis is ongoing, but preliminary results have indicated shifts in copepod phenology following warmer winter temperatures. Full results will be analyzed to observe any trends in species abundance and diversity and further assess their potential correlation with long term climate patterns. This project will contribute to a better understanding of climate driven changes in estuarine zooplankton communities.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Goedken, Mia	Walters, Wendell	Evaluating Concentration Methods for Isotope Analysis of Low Nitrate Concentrations View Full Text Abstract Text The stable isotopes of nitrogen and oxygen (δN, δO, and ΔO) in nitrate (NO3-) have proven to be powerful tools for investigating the sources and atmospheric transformation processes of this critical biogeochemical compound. Although significant advancements have been made in techniques to quantify the isotopic composition of NO3-, accurately measuring isotopes at low nitrate concentrations (i.e., below 1 μM- NO3-) remains challenging. These limitations hinder our ability to obtain isotopic data from certain environmental samples, such as ice cores and pore waters, where nitrate levels are often very low. Here, we evaluated several nitrate-concentration methodologies that included boiling, freeze-drying, fraction collection, and solid-phase extraction, using simulated ice core meltwater with low nitrate concentrations under varying pH and ionic strength conditions. Here, we evaluated these various methodologies using the following criteria: (1) evaluating the accuracy of the nitrate concentration using percent recovery, (2) comparing the isotopic composition to that of a known nitrate standard, and (3) analyzing the time and efficiency of the proposed methods. Overall, nitrate solid-phase extraction was found to be the most suitable option to maximize percent recovery (103% ± 7.8%; n=20). Further, the analysis of the ????¹⁵N and ????¹⁸O isotopes for the NO solid-phase extraction method showed the lowest standard deviations for ????¹⁵N and ????¹⁸O of 0.34 ‰ and 0.59 ‰ (n = 20), respectively. However, detectable isotopic fractionation was associated with the solid-phase extraction technique, necessitating that calibration standards be processed alongside samples using the same extraction procedure. Overall, we recommend the use of solid-phase extraction using AG1-X8 resin with 10 mL of 1 M sodium chloride (NaCl) as the best approach for concentration of NO3- for accurate isotopic analysis.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Markwell, Emma	Chen, Mengqian Roninson, Igor Broude, Eugenia Mack, Zachary	Investigating CDK8/19 in Drug Resistance and Cancer Stem Cell-Mediated Tumorigenesis in HER2+ Breast Cancer View Full Text Abstract Text Many patients with HER2-positive breast cancer (HER2+BC) develop resistance to Paclitaxel (Taxol). This resistance is often linked to the emergence of cancer stem cells (CSCs), a subpopulation capable of self-renewal and therapeutic evasion. Based on preliminary studies suggesting that CDK8/19 activity regulates pluripotency and tumor adaptation, we hypothesized that Taxol-resistant cells would exhibit increased tumorigenicity in vivo and upregulated CSC markers in vitro. To test this, we conducted an orthotopic limiting dilution assay in immunocompromised mice. Twenty-one mice were injected in the mammary fat pad with Taxol-resistant HER2+BC cells at four concentrations: 5 million (5M), 1M, 10K, and 1K cells. We monitored tumor initiation over 15 weeks and compared the results to a previous 65-mouse study of the parental cell line. Surprisingly, no significant differences were found in tumor initiation rates between the groups. In both lines, 5M groups developed tumors by Day 41, approximately 50% of 10K groups formed tumors, and the 1K groups remained tumor-free. These findings suggest that Taxol resistance in this model is not driven by an increased frequency of tumor-initiating CSCs. Instead, Western blot analysis revealed a significant upregulation of MDR1 (Multi-Drug Resistance 1) in the resistant line. While GSEA results for broad pluripotency markers were inconsistent, we have confirmed that the selective CDK8/19 inhibitor SNX631-6 effectively reduces MDR1 expression and reverses this drug-resistant phenotype in adapted cells. This demonstrates that CDK8/19 mediates Taxol resistance through the specific regulation of efflux transporters rather than a global transition to a stem-like state. These results highlight CDK8/19 inhibition as a targeted strategy to suppress MDR1 and restore treatment sensitivity in HER2+BC.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Barrett, Kanyisile Hanner, Chance	Martin, Pamela Weeks, Devin White, Kai Lundy, Aylanah Brown, Kalyn Tomlin, Naomi	From Data Screening to Trust: Strengthening Research Integrity in Black Communities View Full Text Abstract Text Botting refers to the use of automated scripts or coordinated fraudulent actors to complete online surveys while posing as legitimate participants. In online research, botting undermines data validity, inflates sample sizes, distorts statistical estimates, and threatens the credibility of findings. When research centers African American communities, fraudulent responses become particularly harmful, as they distort representation, misinform policy, and erode trust between researchers and historically marginalized populations. This challenge emerged directly in the NC/SC Black Church Study, Understanding the Influence of Black Faith Communities, sponsored by the Department of Psychology and African American Studies, which investigates how Black faith institutions influence health and educational outcomes among Black adults and adolescents. During data collection, 6,020 survey responses were received; however, systematic screening revealed that a substantial portion were fraudulent. To conduct a preliminary review of data integrity, the research team randomly selected 50 cases from North Carolina and 50 from South Carolina for structured review. A multi-step verification protocol was implemented to identify patterns consistent with automated or coordinated submissions. Duration thresholds were applied using Qualtrics metadata to flag entries under 2,640 seconds. reCAPTCHA v3 scores below 0.5 were classified as high risk for automation. IP addresses were examined for duplication, rapid timestamp clustering, anonymizing services, and fraud risk using bulk lookup tools and Scamalytics. Additional safeguards included restricting eligible denominations, excluding non-recruitment locations, cross-checking church affiliations, reviewing attention check responses, and verifying residency through public records. Descriptive statistics will assess the proportion and patterns of fraudulent submissions across screening indicators. These findings will inform best practices for fraud detection thresholds and strengthen methodological rigor in future community-based online research. Rigorous bot detection is both a methodological necessity and an ethical imperative essential for preserving validity and sustaining community trust.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Wade, Chaznine	Reisman, David	Investigating the Protein Coding Capability of a p53 Long View Full Text Abstract Text Human myeloid leukemia is characterized by uncontrolled proliferation and a critical failure of malignant cells to undergo normal differentiation. This impaired differentiation is associated with the overexpression of a specific long noncoding RNA (lncRNA) that contributes to excessive growth and spread of these cancer cells. Although this sequence is labeled as non-coding, a close analysis of this lncRNA identified a prospective small open reading frame with the potential to encode a previously unknown protein. This study aims to determine whether the identified small open reading frame is translated into a functional protein. The region of the gene containing the potential open reading frame will be PCR amplified and cloned into the pBiT3.1-N expression vector, which is designed to attach an 11-amino acid fluorescent protein tag to the candidate protein. Following introduction into human cells, protein expression will be assessed using antibody-based detection approaches, including Western blot analysis and immunofluorescence microscopy. Demonstrating translation of this putative microprotein would challenge the current classification of this transcript as strictly noncoding and suggest an additional layer of regulatory complexity in myeloid leukemia. Ultimately, this work may expand our understanding of hidden coding potential within lncRNAs and identify novel molecular mechanisms contributing to impaired differentiation in leukemia.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Zhang, Grace	Chen, Mengqian Cui, Linda Mack, Zachary	A 'Vibe Coding' Approach to Automating the Drug Screening Pipeline View Full Text Abstract Text High-throughput cell viability assays are a cornerstone of preclinical drug discovery. In our lab, we frequently perform dose-response assays in luciferase-tagged leukemia cells, yet analysis of the resulting final luminescence image relies on manual region-of-interest (ROI) selection and is the rate-limiting step. To address this limitation, we employed "vibe coding": AI-assisted programming where research intentions expressed in natural language are translated into executable code through interactive dialogue with a large language model. Through this development process, we created WellFinder and its batch-processing extension, WellSeeker: a fully automated pipeline for the detection and quantification of 96-well plate images. Implemented as an ImageJ macro followed by an R-based statistical workflow, WellSeeker automatically identifies well locations using multiple detection strategies and infers missing or low-visibility wells. The pipeline measures integrated intensity in each identified well within multiple plate images, greatly reducing hands-on analysis time. The resulting data are fed into an automated R script that performs background correction, outlier rejection, plot generation, and IC50 calculation. By using "human-in-the-loop" refinement, we were able to improve manual analysis results by minimizing human bias and accelerating data processing. This work illustrates how vibe coding democratizes software development in the life sciences, empowering small research teams to independently conduct sophisticated data analyses. By lowering the barrier to custom automation, this technique fosters deeper engagement with computational research and improves experimental reproducibility in cancer biology.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Tomlin, Naomi	Martin, Pamela Parker, Prince Sails-Dunbar, Tremaine Weeks, Devin Brown, Kalyn	Preaching Freedom or Preaching Silence: Black Churches at the Crossroads of Speech and Social Change View Full Text Abstract Text Research on Black churches has frequently reduced their theological diversity to a narrow binary between spiritual withdrawal and social activism. Earlier scholarship characterized segments of Black Pentecostalism as disengaged from public life, emphasizing preparation for the afterlife rather than structural change. Yet the prophetic stream of the Black Social Gospel, exemplified by Martin Luther King Jr. and sustained by contemporary leaders, insists that authentic Christian faith requires public witness against racial and economic injustice. This study examines how Black pastors navigated this theological spectrum in the wake of political violence. Specifically, what did Black Churches pastors preach after the assassination of Charlie Kirk? The sample comprises 10 churches representing diverse theological orientations, ranging from otherworldly Pentecostal traditions to congregations grounded in the prophetic Black Social Gospel. Churches were identified through systematic searches of YouTube to locate congregations with a sustained and significant online preaching presence. Sermon transcripts constituted the sole data source for analysis. The study contextualizes content analysis to code recurring theological themes, rhetorical frames, scriptural references, and explicit calls to civic engagement or restraint. Three research questions guide the inquiry: (1) How do pastors interpret political violence within theological frameworks ranging from otherworldliness to the Black Social Gospel? (2) In what ways do sermons encourage silence, neutrality, or prophetic confrontation? (3) How do theological orientations shape narratives of collective efficacy, empowerment, and community-level change? Preliminary findings will illuminate how Black churches function as sites of moral interpretation during moments of national crisis and how divergent theological commitments influence speech, silence, and pathways toward social transformation.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Tucker, Sonali	Banerjee, Meeta	Coping with Discrimination: Parental Experiences and Socialization as a Buffer for Adolescent Coping View Full Text Abstract Text Youth of color are at risk of being exposed to racial discrimination via direct or vicarious encounters (Benner et al., 2018). These associations have been linked to poorer mental and physical health (Pascoe & Smart Richman, 2009). There has been a call for finding what mechanisms may offset the effects of racial discrimination. Parents of racially marginalized youth can play a role in promoting positive coping strategies to build resilience to racial discrimination using techniques that build ethnic/racial socialization (ERS). ERS has a unique impact on an individual's ability to cope with discrimination (Wang et al., 2020). Individuals who encounter culturally relevant racial socialization messages are more likely to remain resilient when encountering racial discrimination (Brown & Tylka, 2011). Impacts of discrimination can influence the psychological development and wellbeing of racially marginalized youth. Previous findings indicate complex and variable associations between ERS as a buffer between coping and racial discrimination. The current study serves to further empirical data by examining whether parent’s experience with racial discrimination is associated with the parent perception of their child’s ability to cope. The sample consisted of 258 participants, of which the majority identified as male (n=181, 70.2%) and the remainder identified as female (n=77, 29.8%). Self reported measures assessed for perceived discrimination, ERS, parent's perception of their child’s ability to cope. Preliminary analyses reveal significant associations between perceived discrimination, ERS and parent's perceptions of their child’s ability to cope. ERS is positively significant with perceptions of coping as well. Future research will explore whether ethnic/racial socialization can buffer the relationship between discrimination and coping. Implications for how parenting practices may be vital for racially/ethnically minoritized youth in deleterious contexts will be discussed.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Raynor, Danielle	Kristinsson, Sigfus	Moving Towards Longevity: Physical Activity and Brain Health in Super-Agers View Full Text Abstract Text ‘Super-Agers’ is a relatively novel concept in aging research, referring to individuals who are cognitively resilient to the negative effects of aging. This small population maintains a midlife level function and activity in late life, which puts them at lower risk for the development of diseases such as dementia, Alzheimer’s, hypertension, cardiovascular disease, etc. Previous studies have focused on genetics, lifestyle, and physical activity as biomarkers associated with resilient aging, and recent results suggest that physical activity is beneficial to overall brain aging. However, the specificity of time point, frequency, and intensity’s impact on brain health requires further research. This study examines the hypothesis that greater midlife physical activity, moderate to high intensity, is a protective factor that predicts resilient brain aging. Relying on retrospective data from the Age, Gene/Environment Susceptibility (AGES) study, participants aged 85 years of age or older who underwent neuroimaging and cognitive testing across three domains (memory, processing speed, executive functioning) were included in data analyses. Participants who demonstrated preserved cognitive performance, measured as equal to or greater than that of study participants younger than 70 years of age, were classified as ‘Super-Agers’. The primary analysis used logistic regression to examine the association between self-reported midlife physical activity (type & duration) and odds of being classified as a Super-Ager after adjusting for the effects of age, sex, and education. While data analysis is ongoing, preliminary results suggest a graded relationship where participants who were more active in midlife are more likely to retain cognitive functioning in old age.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Falk, Madeline	Poulain, Fabienne	Analysis of Contactin-2 Expression and Sub-Cellular Localization in the Developing Visual System View Full Text Abstract Text Proper brain functioning relies on precise neuronal wiring, a process that begins early in life as axons grow and navigate to their targets. In the visual system, retinal projections form topographic maps, preserving the spatial layout of the retinal ganglion cells (RGCs) they originate from in the retina. Our previous work showed that nasal retinal projections first arborize in the anterior tectum, then refine to the posterior tectum, sharpening the retinotopic map along the antero-posterior (A/P) axis. However, A/P axis refinement does not occur in mutants lacking Contactin-2, a cellular adhesion molecule that promotes neuronal growth and axon fasciculation. This study examined cntn2’s role in axon guidance and map refinement by characterizing its expression and sub-cellular localization throughout development. First, we performed in-situ hybridization (ISH) on embryos fixed from 2-7 days post-fertilization (dpf) to quantify cntn2 retinal expression. We found that cntn2 predominantly localizes to the nasal region of the RGC layer. To track sub-cellular Cntn2 distribution along retinal axons, we generated a plasmid encoding cntn2 fused to Super ecliptic pHluorin (SEP) and TagRFP (SEP-TagRFP-cntn2). SEP is a pH-sensitive GFP that fluoresces at neutral pH, marking membrane-localized Cntn2, while TagRFP is pH-insensitive and fluoresces in all cellular compartments. In muscle cells, we found both SEP and TagRFP at the plasma membrane but only Tag-RFP in acidic organelles, validating our plasmid. In future work, we will express SEP-TagRFP-cntn2 in RGCs to track Cntn2 localization along nasal retinal axons during map refinement. Our results will offer a first visualization of receptor trafficking in axons in an intact embryo and insight into Cntn2’s role in circuit formation and refinement.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Katemba, Arissa	Banerjee, Meeta	EXAMING RACIAL ETHNIC IDENTITY IN LATINX COLLEGE STUDENTS AND ITS PROTECTIVE ROLE IN DEPRESSIVE SYMPTOMS View Full Text Abstract Text Racial discrimination remains a persistent problem in the United States and has been shown to elicit negative mental health outcomes in minority populations (Pascoe & Smart Richman, 2008). Furthermore, research indicates that experiences of racial discrimination is common among college students and is related to poor academic performance, depression, anxiety, and sleep problems (Banerjee et al., 2023; Bravo et al., 2023; Stevens et al., 2018). Considering this evidence along with how the college years are a critical developmental period, this study will continue to examine the role that racial discrimination plays in the psychological outcomes of marginalized college students. Additionally, this study will evaluate the protective role of racial ethnic identity on the association between racial discrimination and depressive symptoms. We hypothesize that (1) more experiences of racial discrimination will be related to higher levels of depressive symptoms and (2) racial ethnic identity will buffer the impact of racial discrimination on depressive symptoms. The current study is comprised of a sample of 607 Latinx college students from a large Hispanic-Serving Institution (HSI) in the Southwestern United States. Participants were asked to report their experiences with current discrimination, as well as their memories of teacher and peer discrimination along with reporting their current depressive symptoms. Preliminary analyses show that there are significant positive associations between all three forms of discrimination and depressive symptoms. Specifically, all experiences of racial discrimination were associated with higher rates of depressive symptoms. Further research will explore the moderating role of racial ethnic identity. We aim to deepen our understanding about how racial discrimination impacts the depressive symptoms of our target demographic and to evaluate whether racial ethnic identity can serve as a protective factor against the negative implications of racial discrimination.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Toth, Madeline	Hollingsworth, Brandon	Naegleria fowleri seroprevalence and risk factors for exposure within the University of South Carolina Campus Community View Full Text Abstract Text Central nervous system infection with the amoeba Naegleria fowleri leads to approximately 16 deaths each year in the US, with only four known survivors among all cases reported to date. Infection typically occurs following forceful inhalation of contaminated water during recreation, leading to rapidly progressing brain swelling and Primary Amoebic Meningoencephalitis (PAM). Despite the rarity of PAM, two recent serological surveys have reported >90% seropositivity to N. fowleri, indicating exposure to the amoeba is likely more common than previously thought. Therefore, the goal of this study is to understand N. fowleri seroprevalence among individuals on the University of South Carolina campus and risk factors for exposure. This study will recruit 500 individuals between the ages of 18-25 from across the country in April and September to donate a dried blood spot. Using these sample dried blood spots, we will do an ELISA to detect the presence of IgG and IgA antibodies to N. fowleri. Additionally, we will ask students questions about their outdoor recreational activities such as swimming, kayaking, and boating. The results of this study will increase our understanding of N. fowleri exposures among individuals in the USC community and how outdoor recreational activities may be associated with exposure. Further, understanding risk factors for exposure can help inform mitigation strategies to prevent future PAM cases.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Belcher, Erin	Chen, Mengqian Broude, Eugenia Mack, Zachary Roninson, Igor	Engineering CDK8/19-mutant breast cancer cell lines using CRISPR-ABE for mechanistic studies of drug synergy View Full Text Abstract Text While targeting the Mediator kinases CDK8 and CDK19 has shown promise in overcoming drug resistance in HER2-positive breast cancer (HER2+ BC), generating accurate genetic models remains a significant technical challenge. Our lab’s conventional CRISPR-Cas9 pipeline requires a multi-step process: creating a full knockout followed by the knock-in overexpression of mutant or wild-type alleles. However, HER2+ BC cell lines (specifically HCC1954, BT474, and SKBR3) frequently fail to survive the subcloning steps following a complete CDK8/19 knockout. This suggests that these kinases may possess essential, kinase-independent functions required for clonal growth and survival in these specific backgrounds. To overcome these viability hurdles and streamline the engineering process, we employed Adenine Base Editing (ABE). Unlike traditional CRISPR which disrupts the entire protein, ABE allows for a "one-step" solution by introducing precise, kinase-dead mutations (D173G in CDK8 and D151G in CDK19) directly into the endogenous genome. This approach inactivates kinase activity while preserving the physical presence of the protein, thereby avoiding the cellular stress associated with a total loss of CDK8/19. By bypassing the need for separate knockout and knock-in steps, this method more faithfully models the action of selective inhibitors like SNX631 in a fraction of the time. This project proved to be challenging and required extensive optimization and troubleshooting. We employed CRISPR-Cas9 adenosine base editing (ABE8e) to introduce CDK8 and CDK19 sgRNA guide sequences into highly transfectable HEK293 cells using Lipofectamine 3000. Our plasmid vector includes a transient GFP selection marker, enabling sequential enrichment of CDK8- and CDK19-mutant cell populations. Successful transfection of the CDK19 guide sequence was confirmed by GFP expression. While further experiments are needed to improve transfection efficiency and introduce additional engineered plasmids, these preliminary results are promising.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Allender, Shannon	Davis, Shannon	The effect of Psat1 deficiency in cell proliferation and hormone production in pituitary gland development View Full Text Abstract Text The gene Phosphoserine aminotransferase 1 (Psat1) codes for an enzyme required for biosynthesis of the amino acid Serine. Previous investigations have found that Psat1 knockout mice have anterior pituitary gland malformations on day 14.5 of embryonic development (e14.5) (Martinez-Mayer et al., 2024), establishing that the enzyme’s metabolic function plays a critical role in pituitary gland development. The purpose of this experiment is to investigate the mechanism behind how the loss of a key metabolic enzyme leads to pituitary malformation. Serine can contribute carbon to the folate cycle, which is necessary for the synthesis of DNA nucleotides and methylation. This means that abnormal development might be caused by low proliferation from reduction of nucleotides necessary for the synthesis of DNA or from an epigenetic effect caused by improper methylation. To begin our investigation, we are determining if Psat1 deficiency disrupts the cell cycle in pituitary progenitor cells. To measure cell proliferation, immunofluorescence (IF) staining for Ki67, a protein expressed in proliferating cells, was performed on embryos deficient in Psat1 during pituitary gland formation. The number of proliferating cells will be determined using ImageJ software to count the proliferating cells in the embryonic pituitary gland for Psat1 homozygous null embryos and their wild type littermates. If the Psat1 knockouts show reduced cell proliferation compared to Psat1 wild type mice, it would point to DNA nucleotide deficiency as a potential cause of anterior pituitary malformation.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Flynn, Kennedy	Hollingsworth, Brandon Lynn, Mary Torelli, Madeleine Zellars, Kia	Environmental Surveillance of Naegleria fowleri in South Carolina Water Bodies View Full Text Abstract Text Naegleria fowleri is a free-living aquatic amoeba and most common cause of primary amoebic meningoencephalitis (PAM) in humans. With an estimated 16 cases per year, PAM has a nearly 97% fatality rate. The majority of PAM cases have been associated with recreational activities in waterbodies, after accidental inhalation of amoeba-contaminated water that reaches the central nervous system. Three fatal cases of this rare infection have been reported in South Carolina within the last decade, including one case in July 2025 from Lexington County. Despite the public health risk, the relationship between environmental conditions and N. fowleri concentration is currently unknown. We will sample 15 waterbodies, consisting of a mix of rivers, small lakes, and large lakes, throughout South Carolina (Upstate, Midlands, and Low Country) that are commonly used for recreation. At each waterbody, we will collect 1L of freshwater from high and low recreational use areas once a month from May to September. During visits, we will also measure biotic and abiotic water conditions, including temperature, dissolved oxygen, and pH. We will then determine N. fowleri concentration within samples by qPCR. Understanding the environmental conditions that influence the concentration of N. fowleri can provide insight into environmental risk as well as determining what is considered an abnormal concentration of amoeba in water. It is essential to determine environmental conditions associated with the concentration of N. fowleri in local water bodies to help inform the public, allowing them to take appropriate preventative measures.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Davis, Abbie	Simoska, Olja	Electrochemical Investigation of Virulence Metabolism in Pseudomonas aeruginosa in Polymicrobial Communities View Full Text Abstract Text Polymicrobial infections represent a major and growing clinical challenge, contributing to increased morbidity, treatment failure, and antimicrobial resistance (AMR). Despite this, most laboratory studies are conducted in monoculture (i.e., single species), overlooking how interspecies can influence pathogenic behavior. Herein, we investigated how microbial community composition influences virulence factor production by Pseudomonas aeruginosa (PA), an opportunistic human pathogen increasingly associated with AMR. A central virulence determinant uniquely produced by PA is pyocyanin (PYO), a redox-active phenazine species that induces oxidative stress in host tissues and shapes microbial competition through extracellular electron transfer. Due to its redox activity, PYO serves as a selective electrochemical biomarker of PA metabolic state. Square wave voltammetry (SWV) was employed to quantify PYO over a 48-h growth period, while spectroscopic optical density (OD) measurements monitored PA cellular growth rates. Mono-, dual-, and tri-species cultures were evaluated, including combinations of PA with Staphylococcus aureus (SA) and Escherichia coli (EC), microorganisms frequently co-isolated with PA in clinical infections. In monocultures, PA produced approximately 250 µM PYO. Co-cultures with SA reduced PYO to around 100 µM, whereas EC nearly abolished PYO production (down to 10 µM). In tri-species cultures, PYO partially recovered (around 45 µM), suggesting that although EC exerts strong inhibitory pressure, PA retains metabolic activity within mixed micro-communities. OD measurements confirmed growth under all conditions, yet did not resolve species-specific contributions. Collectively, these findings demonstrate that polymicrobial interactions significantly reshape the expression of redox virulence factors, with community composition exerting strong control over PYO production. Reduced PYO levels in mixed cultures likely reflect the combined effects of altered PA abundance, metabolic regulation, and interspecies competition. These results underscore the necessity of studying pathogens within clinically relevant microbial communities to accurately model infection dynamics and to inform diagnostic and treatment strategies that account for microbial complexity.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Lynch, Isabella	Rebar, Amanda Burzee, Zachery	The Hidden Curve: How Age and Gender Shape Depression in Veterans View Full Text Abstract Text Background: Mental health disparities among U.S. Veterans remain a significant public health concern. Prior research has documented elevated rates of depression, anxiety, and stress within veteran populations; however, less is known about how these symptoms differ by gender and whether they are moderated by age and branch affiliation. Understanding these patterns is critical for informing prevention and intervention efforts for service members. Objective: Determine whether service-affiliated members differ in overall levels and variation in depression, anxiety, and stress across six weeks, and whether differences vary by sex and/or age. Methods: Participants (N = 99, M age = 59, 36.27% female) self-reported age, gender, and branch affiliation and completed weekly measures of depression, anxiety, and stress. Linear regression analyses tested for gender, age, and gender-by-age effects on overall (intraindividual mean) and variation (interindividual SD) of symptoms, controlling branch affiliation. Results: Depression showed an inverted U-shaped association with age, reflecting between-person differences rather than longitudinal change. Younger adults reported lower depression; midlife participants reported higher depression scores (DASS-21), while older adults reported decreases. The pattern differed by gender. The inverted U-shape was more pronounced for women, with a clearer rise in depression during midlife, while men showed a flatter pattern (age² × gender: β = 0.021, p = .032). No similar curved age effects were found for anxiety or stress. Conclusion: Stress, anxiety, and depression among Veterans remain public health concerns. Mean depression scores vary by age and gender, with women showing greater changes across age than men. These findings highlight the need for age- and gender-informed mental health care to better support vulnerable Veterans.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Havard, Madeyn	Chen, Mengqian Mack, Zachary Ma, Michael Mogila, Vladic	Genotyping and Breeding of an Inducible Double Knockout Mouse Model to Study CDK8/19 Paralog Specificity View Full Text Abstract Text Cyclin-dependent kinases 8 and 19 (CDK8 and CDK19) are paralogous transcriptional regulators critical for tumor growth. While they share overlapping functions, their independent roles in the tumor microenvironment remain unclear. To investigate this, we utilized a tamoxifen-inducible double knockout (idKO) mouse model (Cdk19-/-; Cdk8fl/fl; Rosa26-CreERT2). By crossing this model with wild-type (WT) mice, we are screening the F2 progeny (n=113) to isolate three specific genotypes: (1) Cdk19 knockout with WT Cdk8, (2) WT Cdk19 with inducible Cdk8 knockout, and (3) a Rosa26-CreERT2 control with intact Cdk8/19. Genomic DNA was isolated from ear biopsies and analyzed via a high-throughput PCR and gel electrophoresis pipeline. Each sample was evaluated across four distinct assays to confirm the presence of WT or floxed Cdk8 alleles, the 11bp deletion in Cdk19, and the Rosa26-CreERT2 transgene. To accelerate the generation of these specific cohorts, we implemented an enriched breeding strategy, identifying "near-target" heterozygous mice to establish new mating pairs. This rigorous genotyping process is the essential foundation for our upcoming in vivo studies. By comparing syngeneic tumor growth across these host genotypes, we can distinguish between the redundant and paralog-specific effects of CDK8 and CDK19 within the host environment. These findings will determine whether selective inhibition of a single paralog is sufficient to suppress tumor progression or if dual targeting is required.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Auten, Nathaniel	Matta, Fabio Villegas, Laura	Stabilized Earth Masonry as a Sustainable and Resilient Building Material View Full Text Abstract Text This poster presents ongoing research on stabilized earth masonry as an affordable, sustainable, and hazard-resistant material for low-rise building structures. As communities worldwide seek cost-effective and environmentally responsible construction materials, stabilized earth masonry offers a promising and innovative alternative. The research - conducted under the supervision of Ms. Laura Villegas (PhD student) and Dr. Fabio Matta at USC, in collaboration with Dr. Michele Barbato at the University of California, Davis - explores the mechanical and structural behavior of stabilized earth masonry to be used in seismic-resistant dwellings. A key focus of the study involves evaluating the feasibility of using recycled polyethylene terephthalate (PET) fibers from plastic bottles as a low-cost and structurally efficient replacement for horizontal reinforcement, and polyvinyl alcohol (PVA) microfibers as earth mortar reinforcement to increase the shear strength and toughness of the mortar joints. Experimental efforts include characterization of earth masonry blocks, mortar, steel rebars (used as vertical reinforcement), and fiber-reinforced specimens to understand material interactions and mechanical properties of each component. This project utilizes an advanced measurement technology developed at USC - Digital Image Correlation, which enables an accurate non-contacting and sensor-free measurement of surface deformations and crack development during testing. The findings of this research will contribute to the body of knowledge that is necessary to support the development of design provisions, making it possible for owners and designers to adopt stabilized earth masonry in hazard-prone regions in the US. By incorporating locally sourced soils and recycled plastic fibers, this earth masonry system enables a reduction in energy demand, transportation needs, construction costs, and environmental impact typically seen in more conventional materials, while ensuring a comparably safe structural performance. Ultimately, this work contributes to the advancement of environmentally friendly, regionally adaptable building systems capable of improving long-term community resilience against seismic events.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Walton, Hannah Green, Cassidy	Coulombe, Brianne	Positive Parenting and Child Persistence: The Mediating Role of Self-Efficacy View Full Text Abstract Text Positive parenting (i.e., high support, low hostility, low intrusiveness) is related to positive outcomes for children (e.g., emotion regulation, self-esteem, and academic achievement; Planalp et al., 2023; Chen et al., 2019). Specifically, positive parenting supports the development of persistence, the ability to sustain effort despite challenges (Fang et al., 2017. Indeed, Wang and Wang (2023) demonstrated that positive parenting was associated with greater self-efficacy in children aged 10-11, and Lyman and colleagues (1984) found that self-efficacy positively predicted child persistence. Understanding pathways to persistence across the transition to formal schooling is critical as children are expected to engage in tasks that require sustained effort (e.g., learning to read). The present study evaluated a mediation model wherein positive parenting at age 4 was expected to predict child persistence at age 8 via self-efficacy at age 6. Participants were 250 parent-child dyads from an ongoing longitudinal study (50% assigned female at birth; 46% Latine). At age 4, parenting was observed during structured teaching tasks adapted from prior work (Block & Block, 1980). Independent coders evaluated the extent to which the parent demonstrated high levels of warmth and low levels of intrusiveness and hostility. At age 6, teachers rated children’s self-efficacy on a single item ranging from 1 (poor) to 5 (excellent). At ages 4 and 8, independent coders evaluated the extent to which children-maintained effort when challenged on teaching tasks (Block & Block, 1980). Descriptive and bivariate statistics are reported in Table 1. Mediation analyses conducted in Hayes’ (2013) PROCESS procedure revealed a significant indirect effect of supportive parenting on persistence via self-efficacy, controlling for child sex, race/ethnicity, and prior persistence (see Table 2). Consistent with Bandura’s (1997) social-cognitive framework, self-efficacy develops through experiences and supportive feedback, underscoring its relevance as a potential intervention target for promoting children’s motivational and persistence-related outcomes.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Vann, Sarah	Pellegrini, Christine Horn, Kailyn	The Impact of Physical Activity on Chronic Disease View Full Text Abstract Text Introduction Most adults after knee replacements are overweight and have low activity levels. It is unknown how activity is affected by medications and other chronic illnesses post-op. This study examined the correlation between physical activity and the number of chronic illnesses and prescription medications in adults with obesity and knee replacement. Methods This study used data from a randomized controlled trial examining a weight loss program in adults after knee replacement. Participants reported medications and diagnosed chronic illnesses, specifically diabetes, hypertension, coronary artery disease, depression, anxiety, kidney disease, and cancer. Moderate-vigorous intensity physical activity (MVPA) was measured using an actigraph accelerometer worn around the waist for 7 days . Spearman’s rank correlations were used to examine the relationship between physical activity and chronic illnesses and medications. Results Participants (n=179, age: 65.95±8.39, BMI: 33.91±4.57, 73.7% White, 68.2% female) engaged in 8.3±11.0 min/week of MVPA and were 80.6±20.6 days post knee replacement. Almost all (94.4%) took medications with many (71.5%) taking three or more and 79.9% reported having at least one chronic illness. More chronic diseases and prescription medications were associated with less MVPA (chronic diseases: r= -0.21, p=0.005; medications: r=-0.30, p<0.001) and steps/day (chronic diseases: r= -0.19, p<0.05; medications: r=-0.20, p<0.01). Discussion Having more chronic diseases and taking more medications is associated with less MVPA and steps/day. Therefore, less MVPA after knee replacement is associated with more chronic illnesses and prescriptions needed. Health care providers may need to also consider comorbidities and medications when recommending physical activity after knee replacement.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Striz, Sage	Hollis, Brian	Direct and indirect effects of male exposure on female fitness in Drosophila melanogaster View Full Text Abstract Text Sexual reproduction necessarily requires some degree of cooperation between males and females but can sometimes also be characterized by antagonism that arises from the different fitness interests of the sexes. Previous research has shown conflicting effects, both positive and negative, of elevated male exposure on female Drosophila melanogaster. Most prior research supports negative effects, as increased exposure is believed to lead to male-inflicted damage, increased female energy expenditure, and harmful effects from male seminal proteins. Other work has shown that increased exposure to males can be beneficial due to increases to early life reproductive success. To experimentally test whether the net effect of exposure to males is positive or negative for female fitness, I manipulated male exposure levels of female flies. Female D. melanogaster were exposed either continuously or intermittently to males. Continuously-exposed females spent 4-day cycles with a single male. Intermittently-exposed females only spent the first day of matched 4-day cycles with a male. Males were replaced after each cycle. Cycles were repeated 3 times, and offspring were counted to determine direct fitness effects. I also collected offspring from females to assess indirect fitness effects. Progeny from male and female offspring of the previous maternal generation were used to assess indirect fitness effects of prior male exposure.. Results show a ‘rebounding’ effect in the first generation, as during days in which ‘L’ females are not exposed to a male, they exhibit significantly less offspring production in comparison to ‘H’ females. On days when ‘L’ females are re-exposed to a male at the beginning of a new cycle, they exhibit significantly more offspring production in comparison to ‘H’ females. As for indirect effects, only daughter fitness was affected. The results suggest that females directly benefit from male exposure, although some fitness gains may be lost in subsequent daughter generation.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Walsh, Ella	Brown, Michelle Wright, Kira	The Role of Positive Peer Relationships in the Association between Childhood Emotional Maltreatment and Adolescent Internalization View Full Text Abstract Text Childhood maltreatment is a significant predictor for internalizing problems during adolescence, such as depression, anxiety, difficulties in peer relationships, and other mental health issues (Berzenski, 2019). Psychological problems can significantly impair quality of life and day-to-day functioning (Berzenski, 2019). However, recent research suggests that positive peer relationships may be able to act as a moderator on the association between childhood maltreatment and the risk of internalizing problems during adolescence (Silva et al., 2025). Furthermore, emotional maltreatment specifically has not been addressed in this context despite strong associations with internalizing symptoms (Falgares et al, 2024) and lower positive friendship qualities (Zhou et al., 2025). The present study examines the role of positive peer relationships as a buffer for adolescents internalizing their problems and having experienced emotional maltreatment, while controlling for gender and age. As part of a larger longitudinal study, adolescents (N = 86) with and without histories of maltreatment completed an initial in-person visit (T1) and a 6-month follow up (T2). Caregivers reported on adolescents' emotional maltreatment experiences, and adolescents reported closeness with their best friend at T1 and internalizing symptoms at T2. Results showed that emotional maltreatment significantly predicted internalizing symptoms (β = 2.63, p = .030). This effect was moderated by closeness in the friendship (β = -2.59, p = .027), such that the association between maltreatment and internalizing symptoms was weaker among youth reporting a higher level of closeness with their best friend. The final model accounted for approximately 24% of the variance in internalizing symptoms. The findings suggest that positive peer relationships can act as a buffer in the association between emotional maltreatment and internalizing problems during adolescence. This reinforces the importance of developing strong peer support systems to promote adaptive development and mental wellbeing, specifically during critical developmental stages for childhood and adolescence.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Goodwin, Riley	Meekins, Benjamin Shimpalee, Sirivatch Likit-anurak, Kris	Electrochemical Performance Degradation of PBI Membranes Under Accelerated Stress Testing View Full Text Abstract Text Accelerated stress testing (AST) was conducted to evaluate the electrochemical durability of PBI membranes in fuel cells under repeated voltage cycling. Each membrane underwent potential cycling between 0.95 V and 0.60 V, with performance characterization performed after break-in, 10,000, 20,000, and 30,000 cycles. At each interval, polarization (IV) curves, electrochemical impedance spectroscopy (EIS), and electrochemical surface area (ECSA) measurements were collected to assess changes in resistance, catalytic activity, and overall cell performance. EIS analysis showed relatively stable ohmic resistances with variation of less than 10 mΩ for beginning of life (BOL), 10k, 20k, and 30k cycles, indicating minimal bulk resistance degradation over cycling. These resistances were used to correct cell potential and determine the iR-free potential. Polarization curves revealed increased voltage losses at higher current densities after cycling, with performance degradation most evident when comparing BOL to 10k cycles. ECSA measurements demonstrated a progressive decrease in active catalyst area with increasing cycle numbers, with most reduction occurring after 30,000 cycles. Ongoing work focuses on alternate PBI membranes and small potential cycling windows to further evaluate and compare durability trends.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Espinosa, Cole Tran, Sarah	Oskeritzian, Carole Madden, Michael	Computational Modeling of Interactions Between Gut Microbial Metabolite Capnine and Sphingosine-1-Phosphate Receptors 1 and 2 View Full Text Abstract Text The human microbiome is a complex ecosystem of microorganisms that inhabit organ systems. These microbes produce bioactive metabolites that can mimic human endogenous bioactive molecules and modulate the host immune system. Sphingosine-1-phosphate (S1P) is an endogenous sphingolipid (SL) that coordinates immune cell trafficking and activation by binding to a class of G-Protein-Coupled Receptors (GPCRs) known as Sphingosine-1-Phosphate Receptors (S1PRs). Sulfonolipids (SoLs) are bacterial metabolites structurally similar to human SLs, of which capnine strongly resembles S1P. We hypothesized that the structural similarities between capnine and S1P may enable capnine to bind to and activate S1PRs, altering downstream signaling. To explore this, we conducted computational chemical modeling via molecular docking. We used docked S1PR2(Protein Data Bank ID: 7TD3) and S1PR1(Protein Data Bank ID: 7WF7) with capnine (LMSP01080041) and S1P (LMSP0105001) in the Autodock suite, and visualized results with PyMoL. The molecular docking demonstrated that capnine achieved a similar binding configuration and affinity to that of S1P in S1PR2/S1PR1, supporting that capnine may interact with S1PR2/S1PR1. Overall, our molecular docking analysis suggests that microbiome-derived metabolites like capnine may bind to and modulate S1P/S1PR signaling axis.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Callahan, Finleigh	Hosseini, Seyyedamirhossein LeBarron, Christopher	Effect of Experimental Reaction Conditions On Dimerization Rate of Nickel(II) Salen Electrocatalyst View Full Text Abstract Text Reaction conditions such as solvent-supporting electrolyte (SSE) play a significant role in influencing electro-organic reaction pathways and thus product distribution. However, there exists a distinct lack of detailed study into the nature and trends of such contributions due to the absence of a multicomponent platform for such analysis through the extraction of elementary reactions steps to evaluate the reaction pathway and corresponding reaction rates. Herein, we report the development of an electroanalytical method based on cyclic voltammetry (CV), numerical simulation using DigiElch, and electrolysis supported by gas chromatography thermal conductivity detection (GC-TCD) to investigate the role of SSE and solvent in the dimerization rate of nickel(II) salen and subsequent electrocatalytic performance. By simulating the CV current response of nickel(II) salen, a pervasive error in the anodic peak height was determined to be a previously unreported dimerization process of two electrogenerated nickel(I) salen complexes. By adjusting the simulation parameters to maximize agreement with experimental results, the dimerization rate can be quantified for various reaction conditions.This dimerization rate was found to shift according to SSE and solvent identity, allowing for precise control over the dimerization reaction. The importance of controlling this dimerization can be observed in the established model system of electrochemical hydrogen evolution reaction (HER) via nickel(II) salen electrocatalyst. Through this cycle, electrogenerated nickel(I) salen is protonated by hexafluoro-2-proponol (HFIP) in organic solvent. Two protonated nickel complexes then perform a hydrogen atom transfer to produce H2 gas and two nickel(II) salen. Higher dimerization rates correlate with more pronounced indicators of electrocatalysis with the same reagent concentrations. Constant potential electrolysis was performed using various reaction conditions to produce detectible quantities of H2 gas, further supporting this conclusion.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Reed, Katherine	Arjmandi, Meisam Farrar, Reed Ashjaei, Samin Marlowe, Madeline	Cortical Responses to Vocoded Naturalistic Speech in Simulated Cochlear Implant Listening View Full Text Abstract Text Cochlear implants are neuroprosthetic devices that provide individuals with severe-to-profound hearing loss access to sound by directly stimulating the auditory nerve and bypassing damaged cochlear hair cells. While cochlear implants can significantly improve speech perception for many users, there is high variability in outcomes across recipients. Some individuals are able to understand speech at a level similar to those with typical hearing. While others continue to experience difficulties, especially in environments with background noise, such as restaurants. Understanding the neural mechanisms that drive this variability is a major focus in auditory neuroscience research. To investigate contributors to outcome variability, our lab uses vocoded speech to simulate cochlear implant processing in normal-hearing participants while measuring cortical activation with functional near-infrared spectroscopy (fNIRS), a neuroimaging device that measures changes in oxygenated and deoxygenated hemoglobin as an index of neural activity. In a previous experiment, participants completed a vowel identification task in quiet and noise under varying levels of spectral degradation. While this study design allowed us to tightly control specific acoustic features of the stimuli, the stimuli were brief, limiting our ability to examine sustained neural processing. Because real-world listening involves continuous, meaningful speech rather than isolated phonemes, we developed a storytelling design using segmented children’s stories presented in varying vocoded conditions, in noise and quiet. This design more closely reflects real-world listening by creating an environment where sustained auditory processing under spectrally degraded conditions is necessary. By examining cortical responses during naturalistic speech processing, this work represents a critical step toward identifying neural markers that may help explain individual differences in cochlear implant success and ultimately inform more personalized intervention strategies.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Henderson, Emily	Fillo, Jennifer	Resilience as a Moderating Factor of Adverse Health Outcomes after Childhood Adversity in Military Populations View Full Text Abstract Text Adverse childhood experiences (ACEs)—experiencing or witnessing abuse, neglect, or household dysfunction before age 18—are linked to poorer overall health, functioning, and quality of life in adulthood. Moderating factors, such as dispositional resilience, can buffer the impact of early adversity by influencing how individuals cope and seek support. US military service members are nearly twice as likely as civilians to have experienced ACEs. However, there is little research examining ACEs in this population, despite them experiencing unique stressors (e.g., combat exposure, frequent relocations) that may interact with early adversity in distinct ways. This study addresses the gap in the literature by examining (1) relations between ACEs and health-related quality of life in adulthood, and (2) the potential protective role of dispositional resilience to moderate these effects, among a sample of US military service members. Data were drawn from a study of US Army Reserve/National Guard service members (N=822). ACEs measures assessed childhood physical abuse, verbal abuse, sexual abuse, neglect, and witnessing abuse of others. The health-related quality of life (HRQoL) measure included both physical and mental health functioning. Regression models examined the main and interactive effects of ACEs types and dispositional resilience predicting HRQoL, controlling for sex and age. Approximately 13% of participants reported experiencing some form of physical or sexual abuse. Psychological abuse was the most common type reported, followed by physical abuse, neglect, and witnessing abuse of others in the household. Regression analyses are ongoing and will be reported in the final presentation. Findings will reveal the relative impact of specific types of ACEs on service members’ quality of life, as well as how dispositional resilience may mitigate these negative effects. Taken together, results will provide information essential for developing targeted behavioral health interventions and supporting the well‑being of service members.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Poston, Cooper	Edwards, Kay	The "Swamp Gas" Moment: The 1966 Michigan UFO Sightings and the Cold War Culture of Anxiety View Full Text Abstract Text This research examines the 1966 Michigan UFO sightings to analyze the cultural and psychological history of the Cold War in the United States. Starting out as reports of unexplained lights in the skies over multiple towns in rural Michigan, the incident quickly evolved from a local mystery into a national media episode involving scientists, the United States Military, and the United States Congress. Using newspaper coverage, press releases, television interviews, and government records, the presentation argues that these Michigan sightings were more than a small incident in the broad analects of UFO folklore. Instead, they reflected deeper Cold War anxieties surrounding aerial defense, technological uncertainty, and public trust in scientific and governmental authority. Eyewitness testimonies, police interviews, and increasingly sensational media coverage turned individual reports into a national story. As newspapers and wire services amplified the event, public intrigue over the Michigan sightings began combining with fears shaped by new technologies and the possibility of nuclear war. Scientific attempts to explain the sightings, like the “swamp gas” explanation, failed to reassure the public, and they only intensified skepticism toward institutions. This growing uncertainty prompted elected officials to intervene, culminating in congressional hearings initiated by then-Congressman Gerald R. Ford. By placing the 1966 Michigan UFO sightings within the broader context of the Cold War, this paper demonstrates how unexplained aerial phenomena became projections of national insecurity. The Michigan sightings reveal an anxious society grappling not only with mysterious lights, but also with deeper questions about government authority, national security, and the limits of scientific knowledge. Above all, this presentation shows how UFO sightings ultimately reveal more about ourselves than they might about anything beyond Earth.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Withers, Hayden	Grillo, Claudia	Effect of Ginseng on obesity and neurogenesis. View Full Text Abstract Text Obesity is becoming a strikingly more present problem as decades are passing. Obesity, which is the accumulation of unhealthy fat levels, comes with a large number of adverse side effects, including cancer, heart disease, hypertension and neuropsychiatric disorders. One of the most notable facts is the bidirectional link between obesity and depression. These conditions both are associated with a variety of biological mechanisms, including energy metabolism and immune activation. One of the lesser-studied areas is the impact that obesity and depression have on neurogenesis, the process for which new neurons are generated within the brain. This project will study hippocampal neurogenesis in a rat model of obesity-induced depressive-like behavior and, specifically whether or not Panax ginseng can restore the formation of new neurons within the dentate gyrus of the hippocampus. The rats were divided into four experimental groups: (1) control diet + vehicle, (2) control diet + ginseng, (3) high-fat diet (HFP) + vehicle, and (4) HFD + Ginseng. In order to determine the presence of newly formed neurons, I performed immunohistochemistry (IHC) for doublecortin (DXC), a microtubule-associated protein that is expressed in immature neurons within the dentate gyrus of the hippocampus. Once I completed the IHC for the DCX, I determined the number of immature neurons in the 4 experimental groups, and I also analyzed the morphology of these neurons with the Neurolucida software. This software allows a quantitative analysis of the neurons including process length, soma size, surface area, and branching complexity. By analyzing the immature neurons within the dentate gyrus, my research will allow for a broader understanding of Ginseng’s role within obesity-induced depression to be identified. With a future goal in mind, this study is a stepping stone to using Ginseng as a potential treatment for obesity-related neuropsychiatric disorders.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Simpkins, Taylor	Vick, Lori	Suffocating Inequities: Assessing the Impact of Air Quality on Individuals With Sickle Cell Disease View Full Text Abstract Text This project involves identifying individuals at risk of experiencing complications from sickle cell disease (SCD) related to air pollution. The study further considered the socio-economic inequalities associated with air pollution. Individuals with SCD experience different severity and frequency of complications. Identifying the underlying causes of these differences could help to mitigate complications. This pilot study involved adults with SCD who completed a cross-sectional survey, including the St. George’s Respiratory Questionnaire, Dr. Jenerette’s Demographic Survey, environmental and health questions, and the Adult Sickle Cell Quality of Life Measurement System 14-Item survey (ASCQ-Me). To assess household behaviors affecting indoor air quality four weekly activity logs were collected for one month. Outdoor air quality index (AQI) data from AirNow.gov was gathered from each participants’ location. A 12-question interview explored perceptions of air quality and the impact of social determinants of health on the home environment. Among ten participants, housing related factors aligned with more complications from SCD. Participants reporting more ventilation problems had more hospitalizations from SCD (M=4.0) compared to no reported ventilation problems (M=1.5). Less frequent air filter replacement corresponded with more hospitalizations (M=3.5) compared to participants who replaced filters more often (M=1.75). Interviews revealed themes of financial burden limiting access to improving indoor air quality. Participants rely on health care providers for air quality information but had limited awareness of formal air quality resources. This study provided insights to help individuals with SCD to make informed decisions and take control of their health. Assessing individuals with SCD to identify those most at risk of complications from indoor and outdoor air pollution will help determine factors relevant to health exacerbations. This study of air pollution and its effects contributes to health promotion science by identifying household and lifestyle factors that may negatively impact health.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Richards, Jackson	Sherman, Brett	The Normativity of Inquiry and Questioning View Full Text Abstract Text The relation between inquiry and questioning has received much attention recently. Specifically, many attempts have been made to codify norms that govern our inquiry in relation to questions. Such norms purport to tell inquirers when it is permissible and impermissible to inquire into a given question. However, it is my opinion that these attempts have failed. In this presentation, I will begin by analyzing some of the most influential norms in this domain and explaining why I believe they fail to give a satisfying account of inquiry and its norms. Then, having made my negative case against popular norms of inquiry, I will offer and make a positive case for what I believe to be a more satisfying account of inquiry, questioning, and the norms that govern them.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Alameri, Mustafa	Hosseini, Amir -, Pavithra	Alternative Pulsed-Potential Electrodeposition of RuO2 Nanoparticles View Full Text Abstract Text Metal oxide nanoparticles (1-100 nm) exhibit size-dependent properties useful for electrochemical energy technologies. Ruthenium oxide (RuO2) is promising because of its high electrical conductivity, reversible redox behavior, and strong electrocatalytic activity. However, RuO2 performance depends strongly on nanoparticle size, dispersion, and interfacial contact with the electrode. Many chemical syntheses require high-temperature steps and stabilizers, which can limit nanoscale uniformity and substrate selection whereas electrodeposition enables direct growth on substrate, but common steady-state methods (cyclic voltammetry, chronoamperometry, galvanostatic deposition) often provide limited control over size distributions. Here we report an alternative pulsed-potential (APP) electrodeposition strategy for producing highly monodisperse RuO2 nanoparticles (NPs) on glassy carbon electrodes. APP alternates cathodic and anodic pulses to introduce deposition and relaxation periods that tune the size and dispersion of RuO2 NPs. By systematically varying anodic and cathodic potentials, pulse time, total deposition time, and Ru precursor concentration, we establish parameter regimes that control nucleation, growth, oxidation state, and the transition between nanoparticle formation and film growth. Scanning electron microscopy quantifies changes in particle size and dispersity, and the observed trends are discussed with respect to APP parameters. High-resolution X-ray photoelectron spectroscopy collected on Au substrates confirms formation of hydrous RuO2 at 1.0 V vs Ag/AgCl. Electrocatalytic oxygen evolution reaction activity of RuO2-modified glassy carbon was evaluated in acidic 0.1 M Na2SO4 (pH 2.5). RuO2 with an average particle size of 60-100 nm achieved lower Tafel slope (⁓50 mV dec-1), and smaller nanoparticles showed higher activity when normalized to electrochemically active surface area. Overall, APP provides a rational framework for designing efficient, size-controlled metal oxide electrocatalysts.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Kane, Amanda	Ruppel, Susan	The Influences of Affect and Credibility on the Illusory Truth Effect View Full Text Abstract Text Repetitive exposure to statements can produce a cognitive bias known as the Illusory Truth Effect (Begg et al., 1992), in which repeated statements are more likely to be perceived as true, regardless of their actual validity. The effect was first demonstrated by Hasher et al. (1977), who presented participants with a series of true and false statements and asked them to rate their truthfulness. The researchers found that participants were more likely to judge repeated statements as true compared to statements they had not previously encountered. Since then, the Illusory Truth Effect has been widely studied, though its implications in the context of social media and rapid information sharing have gained attention more recently. Repeated exposure to information through news outlets and social media platforms may increase the believability of false information, highlighting the importance of understanding this effect in modern communication environments. Recent research has further examined factors that may strengthen or weaken this bias. Pan and Hu (2025) conducted three studies using both true and false statements, some of which were repeated after a brief distraction while others were new. In one study, certain statements were accompanied by warning labels indicating they came from an uncredible source. Results showed that participants rated repeated statements as more truthful than new statements and even more truthful than statements flagged with warning labels. Similarly, He et al. (2025) found that when participants were aware of source credibility, repeated positive statements were rated as more truthful than repeated negative or neutral statements. The current study aims to examine whether the combination of source credibility (credible vs. non-credible) and statement affect (positive, negative, neutral) further influences truth judgments. Participants will first rate statements paired with credible or non-credible sources. After 48 hours, they will rate repeated and new statements without source information.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Anderson, Ashley	Shinkareva, Svetlana Yang, Xuan	Perception and Mental Imagery: A Comparative Study of Physiological Responses View Full Text Abstract Text Mental imagery plays a critical role in affective processing and is thought to exhibit physiological mechanisms similar to those involved in perception. It has been established that physiological mechanisms underlying perception and mental imagery change when evoked by extreme valenced stimuli, but less is known about how these processes compare in everyday contexts. Moreover, mental imagery and audiovisual perception have not yet been compared within the same experiment. Controlled investigation of perception and mental imagery requires stimuli that are matched on valence and arousal across the conditions. To address this gap, the present study validated audiovisual clips and mental imagery prompts in a series of five online behavioral experiments. One hundred seventy-five participants rated each prompt and 15-second clip on valence, arousal, difficulty, familiarity, and vividness. Based on these ratings, we selected a final set of 120 stimuli, 60 audiovisual clips and 60 mental imagery prompts, that were equated on arousal with an even distribution of positive, negative, and neutral stimuli across the two sets. These validated stimuli will be used in a forthcoming psychophysiology experiment examining the underlying physiological responses to perception and mental imagery. Electromyography over the corrugator supercilia and zygomaticus major muscles, heart rate, electrodermal activity, and fingertip skin temperature will be measured, and differences in responses will be examined. Differences in physiological responding across modalities will clarify shared and distinct mechanisms underlying perception and mental imagery in everyday emotional contexts.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Wrigley, Brooke	D'Antonio, Edward	Incorporation of Cytochrome c as a Fusion Partner for the Enhanced Production of Recombinant Hexokinase from Trypanosoma cruzi with Biochemical Characterization View Full Text Abstract Text Chagas’ disease, caused by the protozoan parasite Trypanosoma cruzi, remains a major neglected tropical disease affecting millions, primarily in Latin America, with increasing spread to the United States. If left untreated, it can lead to severe cardiac and gastrointestinal complications. Current therapeutic options remain limited. The parasite’s hexokinase (TcHxK), which is essential for glycolysis in the mammalian bloodstream form of the parasite, is a validated drug target. To enable high-yield production and functional characterization of TcHxK for inhibitor discovery, a soluble fusion protein was engineered using an N-terminal 6x His-tagged Equus caballus cytochrome c (EcCyt c) attached via a flexible linker containing the Tobacco etch virus (TEV) protease cleavage site to TcHxK. EcCyt c gives the fusion protein its distinctive red color, allowing easy visual confirmation of successful expression and purification. This fusion protein strategy can accelerate a structured drug design against glycolysis-dependent T. cruzi which can offer a critical step toward new anti-T. cruzi therapeutics. The 6x His-tagged EcCyt c-TcHxK fusion protein was expressed in Escherichia coli, lysed, and purified by two rounds of column chromatography (Co-NTA affinity and size-exclusion). Red-colored fractions were recovered (indicated by EcCyt c), which corresponded to the presence of the fusion protein. UV-visible spectroscopy confirmed the hexokinase activity of TcHxK that was quantified by an NADPH fluorescence-based enzyme coupled assay Leuconstoc mesenteroides glucose-6-phosphate dehydrogenase. The Michaelis-Menten plot yielded a KM value of 27 μM for D-glucose where the reproducibility was observed with previously published interlaboratory data. This finding is significant because EcCyt c can be present with TcHxK during enzymatic assays as a fusion protein with minor interference; however, we also have the option to cleave the TEV linker using TEV protease. Finally, EcCyt c also enables the solubility enhancement of its protein partner, which facilitates the increased overall protein yield.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Ramamurthy, Rithi	Hung, Peiyin	Bridging the Digital Divide: County-level Telecommunication Capacity and Prenatal Telehealth Uptake in South Carolina, 2018-2023 View Full Text Abstract Text Introduction Telehealth is widely used to help bridge gaps in access to perinatal care. However, barriers remain and data is limited regarding the role of digital divide in prenatal telehealth uptake. Objective The goal of this study is to examine spatial and temporal trends in community telecommunication capacity (i.e., broadband access, digital device ownership) and prenatal telehealth use. Methods This cross-sectional study analyzed county-level factors from three data sources: 1) American Community Survey data from the Census Bureau for maternal sociodemographic factors 2) All-payer hospital-based patient records for telehealth records and pregnancy comorbidity; 3) Medicaid claims data for freestanding units’ telehealth records. Lack of telecommunication capacity was measured as proportion of households without broadband subscription and women with no telecommunication devices (computer, smartphone, tablet, etc.). We categorized these two measures into quartiles. Prenatal telehealth uptake was identified using Current Procedural Terminology (CPT) codes and CPT modifiers. Bivariate analysis and multivariable regression models were used to analyze annual trends and associations between digital capacity and prenatal telehealth uptake rates at the county level, overall and by rurality. Results In South Carolina, prenatal telehealth use has increased from almost none in 2018 to an average of 1.91% in 2023. Rural-urban differences in telecommunication capacity persist; as of 2023, 15.6% of rural noncore women versus 9.6% of urban women had no telecommunication devices. Prenatal telehealth uses consistently remained higher in counties with highest vs lowest quartile broadband access: peaking at 2.6% (standard deviation [SD], 0.7%) vs. 1.8% (0.6%) in 2020, and by 2023, the disparity had widened to 2.4% (1.6%) vs. 0.1% (1.2%). Urban counties had better access to digital devices and broadband compared to rural noncore areas, which exhibited the largest access gaps. Conclusion Geographic and socioeconomic disparities in prenatal telehealth uptake highlight the need to address the digital divide across communities as a structural barrier.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Barrett, Jamie	Osbaldiston, Richard	It’s not weighing on you anymore: Weight loss and self-esteem View Full Text Abstract Text Much research has been done on the physiological effects of weight loss, but much less has looked at the psychological effects of weight loss. One psychological variable that is related to just about every component of the human experience is self-esteem. We started with the research question “How strongly is weight loss related to increase in self-esteem?” To answer this question, we did a search for studies using two traditional literature search tools (PsycInfo, Google Scholar) and four new AI-based research tools (Semantic Scholar, Consensus, Primo Research Assistant, and Elicit). In addition to answering the research question, we wanted to compare the use of traditional research tools with new AI-based research tools. Our findings are that there is a moderate relationship between weight loss and self-esteem improvement (Cohen’s d = 0.52), although there is a significant amount of heterogeneity in the studies.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Suber, Avari	Lee, Dongkyu	Understanding Thermoelectric Behavior of Substrate-Free Oxide Thin Films View Full Text Abstract Text Thermoelectric (TE) devices are essential for sustainable energy systems because they directly convert temperature gradients into electrical power without moving parts, enabling efficient waste heat recovery and thermal management. La0.8Sr0.2CoO3 (LSCO) is investigated due to its promising thermoelectric properties and potential to enhance the power factor in flexible, freestanding membrane architecture. In this work, we introduce a freestanding membrane strategy to engineer the TE properties of LSCO. Epitaxial (001) oriented LSCO thin films were grown by pulsed laser deposition on single-crystal SrTiO₃ substrates. Water-soluble sacrificial layers, Sr₂CaAl₂O₆ (S2C1AO) and SrCa₂Al₂O₆ (S1C2AO), were employed, along with a polyimide (PI) protective layer, to preserve membrane integrity during release. After complete detachment, the LSCO membranes were transferred onto the PI tape. The resulting LSCO (001) membranes exhibited either flat or wrinkled surface morphologies, depending on lattice mismatch with the sacrificial layers. These structural differences provide a platform to study how strain relaxation and surface texture influence intrinsic TE performance. Electrical conductivity (σ) and the Seebeck coefficient (S) were measured, since the power factor (PF = S²σ) reflects the efficiency of charge carrier transport under a temperature gradient. Comparative analysis shows that the wrinkled membrane exhibits reduced electrical conductivity due to strain-induced carrier scattering, while the Seebeck coefficient remains relatively unchanged. In contrast, the flat membrane maintains high conductivity with minimal variation in S, resulting in higher power factors. These results clarify the relationship between strain relaxation, morphology, and thermoelectric transport in flexible LSCO membranes. Overall, this study provides practical design guidelines for flexible oxide-based TE devices and establishes a reproducible framework for evaluating freestanding epitaxial oxide films in realistic device configurations.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Kalaga, Pranav	Ray, Swapan	Quantum Dot Bioconjugates Advanced with Click Chemistry and Artificial Intelligence for Glioblastoma Imaging and Intervention View Full Text Abstract Text Glioblastoma (GB) remains one of the most aggressive and treatment-resistant malignancies. Current clinical management, including surgical debulking, radiotherapy, and temozolomide chemotherapy, provides only modest improvements in survival for GB patients. Persistent challenges in accurate imaging, early diagnosis, and effective therapeutic delivery contribute to high recurrence rates of GB and underscore the need for more precise and adaptable technologies for its imaging and intervention. Bioconjugated quantum dots (QDs) have emerged as versatile nanoplatforms for GB imaging and intervention because of their exceptional photostability, tunable emission profiles, and modifiable surfaces. Their nanoscale dimensions enable penetration of the blood–brain barrier, enabling high-resolution visualization of tumor margins and potential delivery of therapeutics. We propose embracing recent advances in QD engineering through click chemistry, which provides site-specific, efficient, and stable conjugation of targeting ligands, peptides, and therapeutic cargos. By enhancing molecular precision and functional diversity, click chemistry-generated QD bioconjugates offer improved selectivity toward biomarkers associated with GB. We further highlight the growing role of artificial intelligence (AI) in optimizing QD design, predictive modeling, image analysis, and treatment personalization. AI-driven algorithms hold promises for refining QD bioconjugation strategies, improving tumor segmentation, and forecasting therapeutic responses. We provide mechanistic insights into QD–cell interactions, including receptor-mediated endocytosis, intracellular trafficking, and signaling pathways that shape biodistribution and therapeutic efficacy. Particular attention should be paid to QD-enabled photodynamic therapy, in which photoactivation generates reactive oxygen species to induce apoptotic death in GB cells. Additionally, we address concerns surrounding the toxicity of metal-based QDs and appraise emerging approaches, including AI-guided material optimization, which aim to enhance biocompatibility and safety. By integrating nanotechnology, chemical precision, and computational intelligence, QD bioconjugates represent a promising and evolving platform for more accurate imaging, targeted intervention, and ultimately, improved clinical outcomes for GB patients.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Childress, Taylor	Wood, Susan Smiley, Cora	Impact of social stress and stress context on oxycodone preference and neural signaling in females View Full Text Abstract Text The opioid epidemic has expanded over the past several decades, and currently 9 million adolescents and adults misuse opioids each year. Opioid use disorder (OUD) is highly comorbid with stress-related psychiatric disorders, including post-traumatic stress disorder. While males have an overall higher rate of OUD, females exhibit a higher rate of stress-evoked relapse behavior. Given this, we designed a study to examine how a history of social stress and re-exposure to stress context impacts opioid preference in females, and the neural mechanisms associated with this response. Our lab has developed[SW1.1] an ethologically relevant stressor whereby female rats view social defeat between two males from within a protected compartment in the aggressor’s cage (Witness stress, WS). In this study, females were exposed to WS or control handling for 15 minutes/day for 5 days. Following this, rats went through conditioned place preference (CPP) training for 3 days to establish a preference for oxycodone (3.0 mg/kg) in the oxycodone-paired side of the chamber. The following day, a subgroup of rats previously exposed to WS were re-exposed to the context of WS (WS CXT), in the absence of the aggressor. Immediately afterwards, rats underwent a final CPP test to assess oxycodone preference, then brain tissue was collected. Brains were micro-dissected to collect 1 mm punches of the nucleus accumbens and the basolateral amygdala, which are important regions for addiction behavior and conditioned stress responses, respectively. Behavioral analysis revealed that a history of WS exposure heightened preference for the oxycodone-paired side, and that WS CXT exposure prior to testing exacerbates this preference. Looking forward, we will conduct high-performance liquid chromatography (HPLC) on these regions to determine neurotransmitter expression associated with stress and addiction behaviors, including norepinephrine and dopamine. Molecular analysis from HPLC will further elucidate the mechanism underlying heightened stress-evoked relapse behavioral response in females.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Dash, Darius	Yuan, Lang	Print Orientation and Manufacturability Analysis of Lattice-Structured Airfoils Fabricated via Laser Powder Bed Fusion View Full Text Abstract Text Additive manufacturing (AM) enables the fabrication of geometrically complex aerospace components that cannot be produced through traditional subtractive or formative manufacturing methods. This project investigates the design and manufacturability of an airfoil-inspired wing structure incorporating advanced internal lattice geometries fabricated using Laser Power Bed Fusion (LPBF). The structure was designed using a NACA-based airfoil profile and incorporates multiple internal lattice configurations, including body-centered cubic, gyroid, and re-entrant architectures, to demonstrate the structural design flexibility enabled by AM. The goal of this research focuses on evaluating the effects of build orientation on manufacturability, support requirements, and geometric fidelity during the LPBF process. Multiple build orientations are analyzed to determine their impact on print feasibility, support architecture generation, material usage, and post-processing requirements. By examining these factors, this study aims to identify optimal printing strategies for complex aerospace components containing internal lattice structures that are difficult to fabricate using conventional methods. Mass comparisons between lattice configurations demonstrate substantial potential for material reduction relative to traditional wing designs while maintaining the overall geometric envelope of the airfoil structure. Future work will incorporate finite element analysis (FEA) to evaluate the structural performance of these lattice architectures under aerodynamic loading conditions and compare them with traditional spars and rib-based wing structures. This research highlights both the opportunities and constraints associated with translating highly complex digital designs into manufacturable aerospace components using additive manufacturing. The results contribute to a broader understanding of how print orientation, internal geometry, and manufacturing strategy influence the feasibility of lightweight lattice-based aerospace structures.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Bommareddy, Nithin	Kacyznski, Andrew	Reframing Health Determinants: A Narrative Review and Introduction of the Macro-Level Determinants of Health (MLDH) Framework View Full Text Abstract Text The issue of healthcare affects every single person on the planet. Illness is a natural part of human life, and thus, effective and efficient healthcare systems are necessary for any successful society. Yet modern healthcare systems remain deeply influenced by a variety of structural and systemic factors that are often underexamined. This paper explores four such factors—Affordability, Proximity to Care, Geopolitics, and Economy—through a narrative review of 37 academic articles and supporting media sources. While these domains are frequently discussed in isolation, they are rarely unified under a common analytical framework. In response, this paper proposes a new conceptual model: the Macro-Level Determinants of Health (MLDH). Unlike the widely used Social Determinants of Health (SDOH) model, which tends to focus on individual and community-level influences, the MLDH model centers structural, national, and transnational factors as primary drivers of population health. By articulating a scalable and policy-relevant framework, this model provides a more holistic understanding of how systemic conditions shape health outcomes—laying the groundwork for more effective interventions and reforms.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Bui, Sidney	Ely, Bert	Purification and Genome Size Determination of Novel Bacteriophages Using SC1004 View Full Text Abstract Text Bacteriophages are abundant and genetically diverse viruses that play essential roles in microbial ecology and have important biotechnological applications. In a college-level microbiology course, undergraduate students isolated bacteriophages from environmental water samples collected across South Carolina, including Rocky Branch Creek, the Congaree River, Irmo Pond, the Thomas Cooper Fountain, and Granby Park. These isolates were subsequently purified and genomically characterized. Using the bacterial host strain SC1004, individual phages were purified through successive plaque assays to establish clonal populations. Plaque morphology was documented and found to be largely consistent among isolates, with plaques appearing predominantly clear, circular, and varying primarily in diameter. Spot dilution assays were conducted to determine phage titers and generate high-titer lysates for downstream analysis. Genomic material was extracted, and PCR amplification was performed to increase DNA yield prior to submission for genome sequencing. Agarose gel electrophoresis and pulsed-field gel electrophoresis were used to estimate relative genome sizes. Acridine orange staining was conducted to differentiate DNA and RNA phages, confirming several isolates as DNA bacteriophages. Although plaque morphology showed limited variation, differences in estimated genome size and titer suggest genetic diversity among phages recovered from distinct aquatic environments. These findings provide preliminary genomic data to support ongoing sequencing efforts and demonstrate the value of integrating undergraduate research with focused molecular characterization.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Horton, Brielle	Martin, Pamela Parker, Prince	Building Youth Resilience: A Preliminary Evaluation of the Lower Richland Disaster Preparedness C.E.A.L. Program View Full Text Abstract Text Decades of empirical scholarship have demonstrated that environmental hazards are not distributed evenly across communities, with racially and economically marginalized populations experiencing elevated exposure to pollution and disaster-related risks (Banzhaf et al., 2019; Kelly-Reif et al., 2016; Macias, 2016; Medina et al., 2022). In Lower Richland, South Carolina, the long-term effects of the 2015 historic flood continue to shape community concerns about recurrent flooding, chemical incidents, and wildfire threats. These persistent risks highlight the need for locally grounded strategies that strengthen preparedness and environmental stewardship. In response, the Lower Richland Disaster Preparedness and Resiliency Citizens Earning and Learning (C.E.A.L.) Science Initiative was established to cultivate youth leadership in disaster readiness, environmental monitoring, and environmental justice advocacy. This study presents a preliminary pre-post evaluation of a summer program implemented with high school students at Lower Richland High School. The program aimed to: (1) educate students about flooding, chemical release, and wildfire preparedness; (2) train youth to develop water and air monitoring protocols and contribute to a community database capturing baseline, routine, and deviant environmental recordings; (3) build community capacity to address environmental justice concerns; and (4) expand students’ knowledge, networks, and experiential exposure to environmental justice careers, including water, soil, sewer, and wastewater management pathways. Fourteen students participated in the summer program. Descriptive statistics from the pre- and post-test assessments will be conducted to examine disaster preparedness knowledge, environmental monitoring self-efficacy, understanding of environmental justice concepts, and interest in related career pathways over the duration of the program. Implications for future research include longitudinal tracking of participants’ civic engagement and STEM trajectories, refinement of youth-led environmental data systems, and integration of community-based participatory approaches to sustain intergenerational resilience. This evaluation underscores the potential of youth-centered, place-based environmental justice education to advance preparedness and community trust in historically vulnerable regions.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Nesmelova, Anna	Frizzell, Norma Cox, Hunter	Exploring the Oxidative Modification of Lysine by Urate View Full Text Abstract Text Several studies have shown that low serum urate levels are associated with accelerated Parkinson’s Disease (PD) progression. Under oxidative conditions, urate is converted to a urate radical, which can continue to degrade further into potentially reactive compounds. Oxidative uratylation describes the addition of urate-derived electrophiles to nucleophilic amino acid residues, which can alter protein function. This modification may alternatively explain why serum urate levels are low in people with neurological diseases linked to oxidative stress. The objective of this project was to purify a uratylated lysine standard that I synthesized to enable the detection and quantification of uratylation in human serum. Last year, I generated the standard for quantitative mass spectrometry to quantify free uratylated lysine. Several steps are used in purification of my standard. (1) C18 zip tips are used to remove the myeloperoxidase (MPO) from the sample, (2) I optimized MCX ion exchange chromatography to enrich the standard. I also cultured HL-60 cells, which were then differentiated to neutrophils using dimethylsulfoxide (DMSO). Neutrophils naturally produce MPO as a part of the immune response and are useful in replication of the uratylated lysine. I activated the neutrophils using phorbol 12-myristate 13-acetate (PMA) to stimulate the oxidative burst. Undifferentiated, differentiated, and differentiated + PMA-activated neutrophils were incubated in the presence of urate, lysine, and hydrogen peroxide to enhance uratylation. Mass spectrometric analysis of these samples suggest that uratylation is reproduced under physiological conditions. Overall, my research has elucidated a novel biomarker for early detection of Parkinson’s Disease, and this methodology will be applied to human serum in future studies.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Taylor, Zachary	Kloos, Bret Wong, Dylan Christy, Hunter Eagles, Amani	Development of a program model for a parent-focused warmline prevention program: Findings from a narrative review View Full Text Abstract Text Call the Moms and Dads is a warmline in its early phases of development. It emphasizes active, empathetic listening as a means of stress relief and mental wellbeing promotion for callers. Currently intended for any adult in need of emotional support, it utilizes trained, non-professional peer support volunteer call-takers. The program’s activities thus far have not yet fully incorporated insights from the most recent literature, which provides an opportunity to update their approach through a literature review methodology. Preliminary research findings provide evidence of the effectiveness of peer-run warmlines for promoting the mental wellbeing of callers (e.g., reducing the need for crisis services, cultivating effective coping mechanisms, and providing a sense of empowerment); therefore, a comprehensive review of effective techniques and approaches for the provision of peer-run warmline services is warranted. Findings provide suggestions regarding appropriate conversational frameworks that call-takers can utilize while speaking to callers, as well as specific competencies that should be developed by call-takers during training. We undertook a narrative review methodology to determine the appropriate scope of the warmline, and effective approaches for caller engagement, combining findings from the literature on warmlines and related program types (e.g., peer support) into a formal program model. An initial literature search phase was conducted to guide program development. Relevant articles were collected via PsycInfo, PubMed, and Google Scholar. Specific program development research questions were developed and additional literature searches were conducted to supplement our findings. Guided by approaches such as Intervention Mapping (Bartholomew et al., 2016) and the FORECAST Tool (Katz et al., 2013), research findings were organized into a logic model of the problem and a logic model of the solution. Additionally, we will describe potential applications and implications of this model for the iterative development of the warmline prevention program and next steps for its implementation.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Pana, Andrew	Ellermann, Melissa	Impact of Lipids on Salmonella enterica serovar Typhimurium IR715 Growth View Full Text Abstract Text Salmonella enterica serovar Typhimurium is a bacterial pathogen that infects the gastrointestinal tract of humans. Once S. Typhimurium enters the gut, the bacterium interacts with a complex environment of microorganisms and metabolites, including host derived and dietary lipid molecules. Certain lipid molecules can have antimicrobial effects on S. Typhimurium, while others can be used as energy sources, improving survival of the bacterium. This project aimed to determine which lipid molecules influence the growth of S. Typhimurium IR715 in vitro in nutrient-rich Luria-Bertani broth at 37C with shaking at 250 rotations per minute. IR715 is a derivative of an S. Typhimurium strain that was originally isolated from heart and liver tissues of 4-week-old chickens. This strain was selected because it is less characterized relative to other strains such as SL1344. To determine whether the lipid of interest altered IR715 growth, we measured bacterial growth and doubling times across a range of lipid treatments using a spectrophotometer. Acetate, between the concentrations of 31.75-63.51 mM, significantly decreased doubling time and extended lag phase without significantly reducing final density. Docosahexaenoic acid, at a concentration of 237.5 M, significantly increased doubling time and slightly increased optical density throughout the growth period. Lauric acid, at a concentration of 1.56 mM, significantly reduced IR715 growth through the growth period. Sphingosine, at a concentration of 18.75 M, completely inhibited IR715 growth. While not all tested lipids produced significant effects, the results support the initial hypothesis that specific lipid molecules can alter S. Typhimurium growth. This indicates that lipid structure and concentration are potential determinants of bacterial growth in the host environment. Understanding how dietary and host-derived lipids influence S. Typhimurium growth provides insight into how the host environment influences S. Typhimurium colonization.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Witzel, Caroline	Reagan, Lawrence Grillo, Claudia Maciejewska, Natalia Calamusa, Sydney Rehm, Jayshree Woodruff, Jennifer	The use of DREADDs to identify a leptin receptor circuit in the rat brain View Full Text Abstract Text In addition to regulating peripheral metabolism, leptin also facilitates hippocampal synaptic plasticity. While locally expressed leptin receptors (LepRs) facilitate hippocampal plasticity, less is known regarding the potential role of lateral hypothalamus (LH) LepRs in hippocampal function. We hypothesize that a leptin-mediated brain pathway from the lateral hypothalamus (LH) to the locus coeruleus (LC) to the hippocampus enhances hippocampal neuroplasticity, including cognition. To test this hypothesis, we developed a lentiviral vector that expresses the designer receptors exclusively activated by designer drugs (DREADDs; hM3Di) under the control of the LepR promoter. This DREADD was injected bilaterally into the LH of adult male Sprague-Dawley rats to specifically activate our hypothesized LH to LC to hippocampus circuit. Validation of the efficacy of the lentiviral constructs was confirmed by immunofluorescence (fIHC) for the reporter gene mCherry and/or a marker of neuronal activation (c-fos). Immunofluorescence identified the expression of mCherry in the LH, which validates the accuracy of the viral injections and the successful expression of the construct. Administration of the DREADD ligand JHU37160 (J60; 0.3 mg/kg) increased fos-like immunoreactivity (FLI) that was colocalized with tyrosine hydroxylase (TH) positive neurons in the LC, demonstrating that chemogenetic activation of LepR-positive neurons in the LH activates the LC. Intracerebroventricular (ICV) administration of leptin (1 μg) also increased FLI in TH-positive cells in the LC. However, we also observed FLI beyond the LC, including FLI lining the 4th ventricle. These results demonstrate that J60 treatment is specifically activating a LepR-mediated LH to LC circuit, while ICV leptin administration is more broadly activating leptin circuits and locally expressed LepRs. Our ongoing studies also demonstrate that J60 administration significantly enhances hippocampal-dependent learning and memory. Collectively, these results support our hypothesis that LepRs activate a LH to LC to hippocampal circuit that facilitates hippocampal synaptic plasticity.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Bhutani, Mira	Perumal, Nandita Owiredu, David	Growth and neurodevelopmental outcomes of HIV-affected children born small and vulnerable in low-and middle-income countries: a systematic review View Full Text Abstract Text Background: Children with perinatal HIV exposure are at increased risk of adverse birth outcomes, including preterm birth, low birth weight (LBW), and small for gestational age (SGA), particularly in low- and middle-income countries (LMICs). Both perinatal HIV exposure and adverse birth outcomes independently influence suboptimal growth and neurodevelopmental outcomes later in life; however, the joint effects of these exposures on longer-term child outcomes have not been systematically studied. Purpose: We conducted a systematic review to evaluate whether the relationship between HIV-exposure (HIV-exposed and infected, HIV-exposed but uninfected) and child growth and neurodevelopmental outcomes is modified by adverse birth status (LBW, SGA, or preterm). Methods: We systematically searched PubMed/MEDLINE, Embase, Scopus, and Web of Science without language or date restrictions to identify peer-reviewed studies that reported on growth or neurodevelopmental outcomes among children ≤10 years with perinatal HIV exposure and adverse birth outcomes. Studies that reported on outcomes in the neonatal period only (<30 days after birth), did not assess adverse birth outcomes, or did not record growth or neurodevelopmental outcomes were excluded. Title and abstract screening and full-text screening were conducted in duplicate. This review was registered with PROSPERO (CRD420261294975). Results: Of the 1,578 titles and abstracts identified after deduplication, 109 full-text articles are undergoing full-text screening, with 28 articles included so far. The results will be summarized narratively, and risk of bias for each study assessed using the Newcastle-Ottawa Scale will be presented. Implications: This review addresses a critical gap in understanding how adverse birth outcomes shape long-term growth and development of HIV-exposed children in LMICs. By identifying children at risk of growth or developmental delays, findings can inform public health practice by supporting early risk stratification and intervention strategies for children with multiple vulnerabilities, strengthening optimal maternal-child HIV care, and reducing health inequities in high-burden settings.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Stewart, Meredith	Hosseini, Seyyadamirhossein Stewart, Skylar	Mechanistic Analysis of the Electrochemical Reduction of o-Nitrobenzaldehyde at Strongly Reducing Potentials View Full Text Abstract Text Nitroarene reduction is a multistep proton-coupled electron transfer (PCET) process that generates several reactive intermediates prior to the formation of the corresponding amine. In ortho-nitrobenzaldehyde (o-NBA), the proximity of the nitro and aldehyde groups enables simultaneous reduction followed by intramolecular cyclization. Although this transformation has been widely reported, its mechanistic details remain insufficiently explored. This work investigates how applied potential and supporting electrolyte composition govern product distribution in the electrochemical reduction of o-NBA. Experiments were carried out in N,N-dimethylformamide (DMF) using tetrabutylammonium tetrafluoroborate (TBABF₄) and lithium perchlorate (LiClO₄) as supporting electrolytes. Cyclic voltammetry was first employed to characterize electrolyte-dependent redox behavior, revealing distinct reduction profiles in each medium. Bulk electrolysis was then performed at a range of potentials in a divided cell containing 5 mM substrate and 50 mM phenol. Constant current electrolysis (CCE) and controlled potential electrolysis (CPE) were evaluated as complementary approaches; while CCE maintains a fixed current and allows the electrode potential to shift during reaction progress, CPE fixes the potential at a defined value, improving experimental precision and mechanistic clarity. Product analysis by GC/MS, LC/MS, and NMR spectroscopy revealed marked electrolyte-dependent selectivity, and it was found that the formation of benzoxazole is an intermediate for o-NBA to form 2-aminobenzaldehyde (2-ABA). Additionally, 2-AAB was identified to undergo self-condensation to form a trimer structure that was observed through LC/MS. Collectively, these findings demonstrate that supporting electrolyte identity and electrolysis methodology significantly impact reaction selectivity and provide mechanistic insight into nitroarene reduction pathways.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Duckett, Wes Merkle, Daniel	Arjmandi, Meisam	Interaural Spectral Mismatch and Spectral Speech Cue Weighting Across Cochlear Implant Listening Configurations View Full Text Abstract Text Listening configuration influences speech perception outcomes in cochlear implant (CI) users, yet the mechanisms underlying these differences remain unclear. One potential factor is interaural spectral mismatch, which occurs when frequency information is represented differently across ears due to electrode placement, residual acoustic hearing, or cochlear anatomy. This review examines how interaural spectral mismatch across unilateral, bimodal, and bilateral CI listening configurations may influence the perceptual weighting of spectral speech cues during speech sound identification. When spectral information differs across ears, listeners may shift reliance toward different cue regions or adopt alternative perceptual strategies for speech categorization. Relevant literature was identified through searches of PubMed, Scopus, Web of Science, and Google Scholar using combinations of keywords including cochlear implant, interaural mismatch, bimodal hearing, bilateral cochlear implants, and speech cue weighting. Studies examining spectral cue processing or speech perception outcomes across listening configurations were included. Across studies, configuration-dependent differences in speech perception are consistently observed, yet relatively few investigations directly examine how listening configuration alters spectral cue weighting strategies. This synthesis suggests that interaural spectral mismatch may play a key role in shaping how CI users prioritize spectral information during speech perception. Understanding these mechanisms may inform CI programming strategies aimed at improving speech perception outcomes and highlights the need for future work directly measuring spectral cue weighting across listening configurations.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Grove, Emma Van Horne, Kate	Waldman, Alan	Genomic instability as a driver of aging: consequences of reduced ZMPSTE24 expression on DNA repair pathway choice View Full Text Abstract Text ZMPSTE24 protease plays a key role in the posttranslational processing of lamin A, an essential protein in a structure called the nuclear lamina that plays a critical role in a variety of nuclear functions. Mutations that reduce or eliminate expression of ZMPSTE24 result in disorders that shorten lifespan and produce symptoms of premature aging. Interestingly, ZMPSTE24 levels are also believed to decrease naturally during the aging process. The form of lamin A produced in the absence of ZMPSTE24 is permanently farnesylated and methylated. Previous studies from our lab and other groups have shown that other mutant forms of lamin A that are incompletely processed disrupt the repair of DNA double-strand breaks (DSBs) and cause a decreased ability to maintain genomic integrity. Changes in DNA repair have also been associated with the normal aging process. To enhance our understanding of both the biology of aging as well as ZMPSTE24 deficiency disorders, we are investigating the effects of ZMPSTE24 deficiency on DNA repair. To do so, we have used CRISPR/Cas9 to knock out the ZMPSTE24 gene in a human fibroblast cell line that contains a DNA repair reporter construct. A DSB can be induced within the substrate through expression of endonuclease I-SceI, and DSB repair events occurring via either homologous recombination (HR) or nonhomologous end-joining (NHEJ) are recoverable by genetic selection. HR is an accurate and templated form of repair, while NHEJ is an error-prone non-templated rejoining of DNA ends. We aim to reveal the impact that ZMPSTE24 deficiency has on DSB repair by investigating if repair pathway choice is altered in the absence of ZMPSTE24. Preliminary results are suggestive of a shift toward DSB repair via error-prone NHEJ. We present our ongoing studies using our model system to investigate the effects of ZMPSTE24 deficiency on genome integrity.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Gerstein, Caitlin	Fillo, Jennifer	Discrepancies in perception of romantic partner alcohol use among military couples View Full Text Abstract Text US military service members/veterans and their romantic partners are at high risk for alcohol misuse. Not only can higher drinking quantity/frequency negatively impact relationship functioning and stability, but research suggests that individuals’ perceptions of their partner’s drinking may also play an important role. However, previous research has not examined relative importance of these factors simultaneously. To clarify these effects, this project examined (1) factors predicting discrepancies in perceptions of partner drinking, and (2) discrepancy’s connection to relationship functioning over time among military couples. Data were taken from a longitudinal study of US Army Reserve/National Guard soldiers and their spouses/partners (N=822 individuals/411 dyads). Drinking frequency and quantity discrepancy variables were calculated by subtracting partners’ self-report from individuals’ perception of their partner’s drinking. Models predicting discrepancy variables examined the main and interactive effects of sex, military status, and individual and partner self-reported drinking. Models predicting relationship functioning variables included sex, military status, individual and partner self-reported drinking, and alcohol discrepancy variables. Across all models, females consistently overestimated their partners’ drinking frequency and quantity compared to males. For models predicting frequency discrepancies, sex differences were most pronounced for veterans, compared to service members and civilians. For models predicting quantity discrepancies, individuals’ higher self-reported drinking predicted greater over-estimation of partner drinking quantity. This effect was more pronounced for females. Analyses predicting relationship functioning are in progress and will be included in the final presentation. Results revealed that sex, military status, and individuals’ own drinking habits impact their tendency to over- or under-estimate their partners' drinking behaviors. Notably, females demonstrated consistent tendencies to overestimate partner drinking, whereas males were more likely to be accurate or underestimate. These findings provide valuable information on factors contributing to alcohol-related perceptual discrepancies and their impact on relationship functioning, which can inform couples-focused interventions for military couples.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Rescorl, Ziana	Fillo, Jennifer	Mental Health and Relationship Instability Among US Military Couples View Full Text Abstract Text PTSD is the most common mental health condition among US military service members (SMs). Mental health problems affect not only the SM, but also their romantic relationships. Whereas previous research has focused almost exclusively on the effects of SMs’ mental health on the relationship, spouses may also experience mental health issues that can harm relationship functioning. This project examined within- and between-person effects of mental health on relationship instability among military couples. Data were drawn from a longitudinal study of US Army Reserve/National Guard soldiers and their spouses/partners (N=172 male-female dyads). Relationship instability was measured as progressive steps partners took toward ending the relationship (e.g., thought about ending relationship, serious discussions with partner, contacted lawyer about divorce). Path analyses examined within- and between-person effects of negative mental health symptoms (i.e., depression, PTSD, anger) on each person’s report of relationship instability, controlling for SM sex. There was no evidence of between-person effects for any mental health variables. However, results revealed significant within-person effects of PTSD and anger on relationship instability, regardless of SM or civilian status. Participants with greater PTSD symptoms and anger reported taking more steps toward ending the relationship. Individuals’ relationship instability at baseline predicted their own report at follow-up, and SM relationship instability at baseline also predicted their partner’s report at follow-up. Results suggest that both SMs’ and partners’ mental health may have important implications for the stability of military marriages, particularly PTSD symptoms and anger. Effects were largely intra-personal; however, steps taken by SMs’ toward ending the relationship appeared to carry over to impact their partner’s behavior one year later. Future research should examine mechanisms through which these effects may occur. Findings underscore the importance of looking beyond the SM and highlight potential targets for future interventions supporting military couples.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Harris, Jonathan	Fillo, Jennifer	The Role of Spouse Social Control in Changes in Problem Drinking During Treatment View Full Text Abstract Text Despite a large literature demonstrating the positive impact of romantic partners for supporting drinking reduction, much less is known about the underlying mechanisms. Social control—deliberate attempts to influence another’s health-related behavior—is a promising candidate, but variation in conceptualization and measurement specificity has led to mixed findings. To clarify these effects, the present research examined the effects of romantic partner social control on changes in client drinking over the course of treatment, comparing the predictive power of a more general (2 factor) vs. more specific (4 factor) scoring of a popular social control measure—the Partner Interaction Questionnaire (PIQ). Data were drawn from a group treatment study for male “problem-drinkers” (N=64) and their female spouses/partners. Outcomes included change in percentage of days abstinent (%DA) and percentage of days drinking heavily (%DH) during treatment (end-start). PIQ responses were scored in 2-factor (positive/negative) and 4-factor versions (emotional support/instrumental support/complaints about drinking/criticizing drinker). Multiple regression analyses examined the effects of partner social control on change in %DA and %DH, controlling for study condition (partner involvement: yes/no) and drinker age. Separate models examined general (2-factor) and specific (4-factor) PIQ scoring. For %DA, the 2-factor model showed no effects of social control. However, the 4-factor model revealed this was due to nearly equal, but opposite effects of complaints about drinking (b=12.10) and criticizing the drinker (b=-10.06). Conversely, there were synergistic effects of emotional and instrumental support, resulting in a significant effect of positive social control predicting decreases in %DH during treatment (b=-5.68). Taken together, results demonstrate social control as an important mechanism through which romantic partners can support, or undermine, changes in drinking over the course of treatment for heavy drinking. Further, findings highlight the value of more specific conceptualizations of social control, particularly for “negative” strategies.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Smith, Spencer	Goldberg, Kelly	Consumptive Resistance on College Campuses: An Investigation of Foodways on The Historic Horseshoe View Full Text Abstract Text Since 2024 students at the University of South Carolina (USC) Columbia campus have been excavating historic sites on the Horseshoe in order to shed more light on the history of slavery on campus. Throughout these excavations artifacts recovered included materials such as worked bone objects, bone buttons and brushes. I will analyze these objects to observe how everyday foodway practices were used by enslaved people as a means of resistance against institutional oppression. Food remains from this site can provide information on how enslaved people navigated and engaged with local resources, knowledge, and networks. In this we can explore how resources, knowledge, and local connections were used as forms of resistance against tyranny. This research can be used to explore how the use of resources, networks, and knowledge affected how enslaved people interacted with foodways, when it came to increasing agency within abusive power structures. By using historical and archeological data to compare and contrast the histories of USC and other universities we can further explore how evidence of resistance varied among people enslaved on college campuses. This will further shed light on the myriad of ways in which enslaved people actively resisted systems of oppression throughout the U.S.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Rajaji Sivaranjani, Anuvarshini Joby Chacko, Angelina	Lu, Qun Chen, Yan-Hua Dixon, Emma	Spatial Regulation of ASAP1 Phosphorylation in Amyotrophic Lateral Sclerosis in Human View Full Text Abstract Text Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that progressively affects motor neurons in the brain and spinal cord causing muscle weakness, paralysis, and ultimately death. The most common genetic cause of this disease is a hexanucleotide repeat expansion (GGGGCC) in the non-coding region of the C9orf72 gene, affecting the C9orf72-SMCR8-WdR41 (CSW) complex. This complex acts as a GTPase-activating protein (GAP) which regulates intracellular trafficking by small GTPase, ARF1. ARF1 activity is also controlled by ARF1-GAP, ASAP1. When ASAP1(Tyr782) is phosphorylated by Src and Pyk2, it leaves ARF1 in a sustained GTP-bound form, over-activating ARF1 to cause dysregulation of vesicle transport. To investigate ARF1 dysregulation associated with ALS, we used immunohistochemistry (IHC) to analyze the expression levels of phosphorylated ASAP1(Tyr782) of the posterior frontal motor cortex (PFMC), cerebellum, and hippocampus formation (HF) from non-ALS control, C9orf72 ALS, and a sporadic ALS (sALS) patient. IHC analysis revealed that phosphorylated ASAP1(Tyr782) expression was altered between non-ALS control, sALS, and C9orf72 ALS in each brain region. In PFMC, phosphorylated ASAP1 (Tyr782) expression was increased in both sALS and C9orf72 ALS when compared to the non-ALS control. In cerebellum, there was no significant difference in ASAP1 signaling patterns between control, sALS, and C9orf72 ALS, while in HF, there was a marginal increase of phosphorylated ASAP1 (Tyr782) expression. Additionally, we observed the greatest ASAP1 (Tyr782) expression signal in sALS, followed by C9orf72 ALS, and then controls. These findings suggest a region-specific dysregulation of ASAP1 in ALS, supporting that altered ARF1 signaling may contribute to disease mechanisms. Supported by NIH R01GM146257/OD031672 and VA Biomedical Laboratory Research & Development Service.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Patel, Om	Schools, Gary	Expression of CDK8 and CDK19 in Mouse Tissue Development and Cancer Progression View Full Text Abstract Text Cancer progression is partly driven by dysregulated transcription, yet the roles of specific regulators remain incompletely understood. Cyclin-dependent kinases 8 and 19 (CDK8/CDK19) are paralogous Mediator kinases that regulate transcription by phosphorylating substrates such as STAT, leading to transcriptional reprogramming required for adaptation to anti-cancer therapies. Although CDK8 has been linked to oncogenic signaling, the distinct and overlapping roles of CDK8 and CDK19 in development and tumorigenesis remain largely unexplored. Individual cells preferentially express either CDK8 or CDK19, rarely both at similar levels, suggesting functional divergence. This study examines their differential roles in transcription, differentiation, and cancer progression using transgenic mouse models. Previous work in the lab developed a mouse model that enables CDK19 knockout (KO) and conditional CDK8 knockout via Tamoxifen, avoiding embryonic lethality of CDK8 KO. Immunofluorescence staining revealed that CDK8 and CDK19 are undetectable in several organs of the double KO (DKO) mice and that CDK8 and CDK19 are differentially expressed in the testes and prostate in wild-type (w.t.) mice. We used syngeneic orthotopic transplantation of EO771 mouse mammary tumors in w.t., CDK19 KO, and CDK8/19 DKO mice. Tumors were analyzed by immunofluorescence for CDK8/19 and markers of fibroblasts, angiogenesis, and proliferation. Fluorescence microscopy showed CDK8/19 absence in stromal and juxta-tumoral regions and decreased tumor-associated fibroblasts and vasculature in some DKO sections versus WT and CDK19 KO; however, these differences were not statistically significant in this small cohort and are being reassessed in a larger study. These findings support the CDK8/19 DKO model for studying breast cancer and suggest a role in regulating tumor-promoting fibroblasts. Further study may reveal therapeutic targets and clarify how Mediator signaling drives cancer progression and transcriptional reprogramming.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
McCay, Palmer	King, Sarah	Vietnam Veterans Oral History Project: Process, Results, and Significance View Full Text Abstract Text For over 50 years, depictions of Vietnam veterans in American culture, ranging from Forrest Gump’s Lieutenant Dan to Taxi Driver’s Travis Bickle, have misunderstood and misrepresented the Americans who served in Vietnam. Vietnam veterans are all too often depicted as “the baby killer,” less often as the “gentle warrior” who (albeit paternalistically) helps the Vietnamese population by building hospitals and orphanages. Since the 1990s, academic works by historians like Christian Appy, Heather Stur, and Meredith Lair have explored the realities of service and homecoming for this generation of veterans. From these historians and existing oral history collections, we know, for instance, that many Vietnam veterans thought that they were going to “fight a clean war,” like World War II. Existing academic works paint a vivid picture of the lives of individuals who served in Vietnam and underline that Vietnam veterans have extraordinary stories to tell and preserve. Speaking to a Vietnam veteran—someone who served on the ground in one of the most infamous and misunderstood wars of the twentieth century—can help answer questions not yet addressed in the historical literature. Building on a foundation of intensive secondary-source reading, this project asks questions raised by existing academic histories. Currently in year two, this three-year project records interviews with Vietnam veterans and preserves those interviews in a new, open-access digital archive. Year one, led by a student researcher who has now graduated, saw the completion of ten interviews. This is my first year working on the project, and I look forward to completing ten interviews by the end of the current academic year.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Ricard, Serria Wright, Jacob (Eli)	Webb, Emily	Sustainable Mosquito Control: Novel Techniques for Reducing Mosquito-Borne Disease Risk While Preserving Environmental Integrity View Full Text Abstract Text New mosquito control strategies are moving beyond reliance on traditional chemical insecticides and more towards sustainable biological and genetic approaches. Advances in molecular biology have introduced novel tools such as Sterile Insect Technique (SIT), CRISPR-based gene editing, and the release of mosquitoes infected with the endosymbiotic bacterium Wolbachia. These methods aim to reduce mosquito populations or suppress their ability to transmit pathogens by altering vector competence. For example, a recent study found that Wolbachia infection can interfere with pathogen replication and modify mosquito immune responses. Researchers observed that more than forty immune-related genes changed their expression in Anopheles stephensi following a bloodmeal when infected with Wolbachia, leading to crucial effects. In particular, infection with the Wolbachia strain wAlbB was associated with reduced reproductive success and decreased infection by the malaria parasite Plasmodium falciparum. Similarly, the SIT reduces mosquito populations through the release of sterilized males that mate with wild females, resulting in no viable offspring. While SIT programs have been promising, they require ongoing releases and can be complemented by emerging technologies such as CRISPR-based genetic modifications. These modifications can target reproductive ability or pathogen transmission. Together, these innovative strategies offer environmentally sustainable alternatives to traditional insecticides by minimizing off-target impacts, reducing the development of insecticide resistance, and either suppressing medically important mosquito populations or interfering with pathogen transmission.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Tyner, Alexandra	Edmunds, Sarah	Life on Their Terms (LOTT): Defining Quality of Life in Neurodivergent Communities View Full Text Abstract Text     The Life on Their Terms (LOTT): Defining Quality of Life in Neurodivergent Communities research study aims to better understand how quality of life is defined and experienced in neurodivergent populations. Current definitions of quality of life may not accurately represent neurodivergent lived experiences because they are influenced and constructed by medical and non-neurodivergent viewpoints (McConachie et al., 2018). The research study uses an accessible survey with structured response options and open-ended questions to investigate how participants define “good” quality of life, along with varying themes of social engagement, autonomy, social and physical environment, interpersonal and community relationships, and support needs.    By centering lived experiences and applying the social model of disability framework, the project seeks to contribute to more inclusive definitions of quality of life that may better inform healthcare practices, disability advocacy, and future research practices. To find themes and variations in how quality of life is perceived and experienced, the study will compare perspectives on quality of life among neurodivergent participants. The ultimate objective is to advance a more person-centered understanding of quality of life that recognizes unique experiences and includes neurodivergent perspectives in quality of life measures. According to preliminary analysis of 18 responses, quality of life is perceived as an all-encompassing experience that includes independence, meaningful engagement in everyday activities, and strong social relationships. Participants found the survey highly acceptable (M=1.5, SD=0.63) and feasible (M=1.25, SD=0.58), rated on a 5-point Likert scale, (1=strongly agree; 5=strongly disagree). Numerous participants reported multiple neurodevelopmental and psychological identities, which suggests that rather than being limited to a single diagnosis, definitions of quality of life may be shaped by complex and overlapping identities. For Discover USC, these qualitative results will be presented in full, along with quantitative results on relative levels of quality of life as reported on standardized measures.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Windsor, Lennox Turner, Kayleigh	Outten, F. Wayne Miller, Kennedy	Elucidating the Molecular Mechanism of Iron–Sulfur Cluster Delivery to IspG through the GrxD–ErpA Trafficking Proteins in Escherichia coli View Full Text Abstract Text Iron-sulfur (Fe-S) clusters are essential biological cofactors involved in gene regulation, electron transfer, and metal homeostasis. A-type carrier (ATC) proteins play a central role in delivering Fe-S clusters to their appropriate apoprotein targets in bacteria and the mitochondrion of eukaryotes. ErpA is an ATC that is required in vivo for maturation of the essential Fe-S dependent enzyme IspG in Escherichia coli. GrxD, the sole monothiol glutaredoxin in E. coli, has been shown to be essential for cluster delivery to both ErpA and IspG under iron-limiting conditions. Our first goal was to establish the order of cluster transfer among GrxD, ErpA, and IspG in vitro using FLPC, UV–visible spectroscopy, circular dichroism (CD) spectroscopy, and size–exclusion chromatography. Preliminary experiments suggest that holo-GrxD alone cannot efficiently mature apo-IspG in vitro, while published data from our lab showed that holo-GrxD efficiently transfers its Fe-S cluster to ErpA. These results support a model where ErpA functions downstream of GrxD. Our second goal was to characterize stepwise cluster transfer from GrxD to ErpA. ErpA coordinates its Fe-S cluster using three conserved cysteine residues. We generated Cysteine to Serine mutants of ErpA cluster ligands to probe stepwise cluster transfer between holo-GrxD and mutant ErpA proteins. Elucidating how the GrxD--> ErpA --> IspG cascade works at the molecular level will help clarify the biogenesis and trafficking pathways for Fe-S delivery to essential downstream targets.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Spivey, Georgia	Chen, Mengqian	Modulating Resistance to Paclitaxel Through Transcriptional Kinase Inhibition in Estrogen Receptor positive (ER+) and Triple Negative Breast Cancers (TNBC) View Full Text Abstract Text Paclitaxel, a microtubule stabilizing chemotherapy drug, is often prescribed for advanced, aggressive, or metastatic breast cancer. Unfortunately, paclitaxel resistance can develop. Our laboratory studies changes in transcriptional activity, regulated by Cyclin-dependent kinases 8 and 19 (CDK8/19), that may promote drug resistance in breast cancer and how pharmacological inhibition of CDK8/19 may prevent or reverse drug resistance. The first goal of this project was to generate paclitaxel-resistant cells. After determining baseline sensitivity to paclitaxel in our breast cancer cell lines (ER+: T47D and TNBC: MDA-MB-468) through cell viability assays, cells were treated for several weeks with paclitaxel doses that inhibited 80-90% of cell survival and photographed for growth pattern and cell morphology assessment. MDA-MB-468 cells were able to survive and proliferate at a 2.5 nM dose of paclitaxel after 10 weeks of treatment. Paclitaxel potency decreased in the adapted cells; the IC50 of parental cells was 1.3 nM, whereas the IC50 of adapted cells was 3.1 nM. In combination treatment of paclitaxel with a CDK8/19 small molecule inhibitor (SNX631-6), IC50 values were lower than treatment with paclitaxel alone. T47D cells are currently being treated with 2.5 and 3.0 nM and cell viability assays are ongoing to confirm adaptation. Another goal of this project is to establish durability, where the adapted cells would continue to exhibit resistance after treatment has stopped. This portion is ongoing as cells are on cycles of release and treatment, and durability is being assessed using cell viability assays and IC50 calculations. Elucidating the relationship between CDK8/19 and the propensity for breast cancer cells to develop resistance to standard of care drugs will help identify mechanisms which drive growth in these intractable tumors and may offer targets for treatment development.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Villanueva, Hannah Maja, Mariko	Pena, Marj	Impact of Pediatric Antibiotic-Induced Dysbiosis on Early-Onset Colorectal Cancer View Full Text Abstract Text Colorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer-related deaths. CRC has been decreasing in individuals over 50 years of age due to increased screening and healthier lifestyle choices. However, its incidence in individuals under 50, known as early onset CRC (EOCRC), has been increasing since the 1980's and is now the leading cause of cancer-related deaths in patients under 45 years old. Although common risk factors for CRC such as obesity, poor diet, and physical inactivity are linked to EOCRC, the causes as to why otherwise healthy and young individuals are susceptible remains unknown. In this study, we hypothesized that prenatal exposure to antibiotics (Abx) will cause dysbiosis leading to more frequent and aggressive tumors as compared to exposure in later stages of life. We used an A/J mouse model to determine if pre-natal exposure to Abx increases the risk of developing EOCRC in the offspring. Pregnant dams were treated with a single round of on eof the most commonly prescribed classes of pediatric Abx: amoxicillin (710 mg/kg), a beta lactam, or azithromycin (250 mg/kg), a macrolide. Control mice were given water or polyethylene glycol (PEG). At five weeks of age, the offspring were treated with azoxymethane (AOM, 10 mg/kg), a carcinogen at five weeks of age once a week for six weeks to induce tumor development. Tumor burden was assessed 14 weeks after the last dose of AOM. The results revealed that Abx did not greatly impact the tumor development in the proximal colon but rather increased the tumor burden in the distal colon, compared to our control groups treated with PEG and water. These findings suggest that Abx treatment in the prenatal developmental role may lead to frequent tumor development in the later stages of life.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Hargrave, Kevin	Patel, Jay	Examining Relationships Between Arm Length and Shoulder Force Production in Baseball Pitchers: An Exploratory Analysis View Full Text Abstract Text BACKGROUND: Glenohumeral joint health and stability are fundamental to baseball throwing mechanics. The shoulder is a primary source of force production (FP) down the upper extremity, utilizing joint actions such as shoulder internal (SIR) and external rotation (SER). Arm length is a measure that may influence force generation due to its role as a lever. Previous studies have examined the relationship between shoulder rotational force and pitch velocity, but not the role of arm length as a contributor to FP. The purpose of this study was to investigate possible relationships between arm length and shoulder FP in baseball pitchers. METHODS: Data from 47 male baseball pitchers (18.87±3.00yrs, 1.83±0.11m, 84.63±12.72kg) were retrospectively analyzed. Arm lengths were obtained via tape measure, and two trials of isometric strength measurements were taken for dominant and non-dominant SIR and SER FP via handheld dynamometer. Pearson correlations were conducted to determine possible relationships between variables. RESULTS: Moderate negative correlations were found between dominant arm length and FP for SIR (r = -.33) and SER (r = -.39). Non-dominant arms found moderate negative correlations between arm length and FP for SIR (r = -.47) and SER (r = -.46). CONCLUSION: These results suggest an inverse relationship between pitcher arm length and isometric glenohumeral FP for dominant and non-dominant arms. Additional exercises and preventative measures for pitchers with longer arms could help to mitigate upper extremity injuries and may enhance athletic performance. Future research could investigate shoulder FP differences in pitchers and position players or look further into these relationships within pitching kinematics.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Amisano, Maria Boyle, Connor	Salman, Nadra Newman-Norlund, Sarah Riccardi, Nick Fridriksson, Julius Bonilha, Leonardo	Exploring the nuanced relationship between executive inhibitory control and accelerated brain aging View Full Text Abstract Text Tasks to assess executive function have been paramount to identifying relationships between physiological brain markers and aspects of cognition. Previous studies have explored Stroop task performance in relation to regions heavily tied to executive function, including the dorsolateral prefrontal cortex, inferior frontal gyrus, and anterior cingulate cortex (Collette et al. 2005). Brain Age Gap, the difference between chronological age and estimated brain age, has emerged as a novel metric for assessing structural brain health. However, the application of this tool in regards to executive control has not yet been fully explored. Thus, this study seeks to investigate the relationship between regional brain age gap and executive inhibitory control. We have collected MRI and Stroop data from 109 participants (83 females and 26 males aged 40-80) at the Aging Brain Cohort (ABC) at UofSC. Using the volBrain pipeline (Nguyen et al., 2024) and structural T1-weighted MRI scans, we have calculated regional brain age gaps across 144 different brain regions for each participant. We plan to perform a correlation analysis between regional brain age gap and stroop performance while controlling for multiple covariates such as sex and education, and correcting for multiple comparisons. We hypothesize there will be a significant negative correlation between Stroop Performance and accelerated brain aging in the regions previously found to be associated with executive functions such as inhibition. This work will build on previous literature on the relationship between executive functions and brain health measures. Ultimately, we aim to provide a clearer lens on the implications of accelerated brain aging, exploring the intricate relationship between executive function and brain health.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Ventola, Matthew	Palomares, Melanie Vahlstrom, Christine	Investigating the Role of Attention in Number Line Estimation View Full Text Abstract Text Space and number are fundamentally connected. Smaller numbers are associated with the left side of space and larger numbers are associated with the right side of space, a phenomenon formally coined as the Spatial-Numerical Association of Response Codes (SNARC) effect (Cuttino et al, 2006). This research investigated whether number-space mapping is affected by attentional cues, such as the presence or absence of endpoints and arrows pointing to the left or right presented near fixation. Participants were asked to locate the position of numerical targets within (i.e. interpolation) or beyond (i.e. extrapolation) a line segment. The number line ranged from -500 to +500 in the interpolation conditions and -20 to +20 in the extrapolation conditions. If endpoints affect responses, then the interpolation and extrapolation conditions should produce different error patterns. Moreover, if arrows implicitly affect responses, then responses should shift consistently with the direction of the arrow. Additionally, participants performed a KTEA math assessment and a debriefing questionnaire to determine whether basic computational fluency and positive attitudes towards arithmetic correlate to higher performance in the number line tasks. Our study has implications in cognitive science, education, and medicine, potentially redefining early math education techniques and neurological disease rehabilitation.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Monnell, Bryan Wandel, Ethan	Shtutman, Michael Korunova, Elizaveta	U2OS Stress Granule Liquid Phase Separation and Rheological Properties of Cytoplasm View Full Text Abstract Text Cellular survival depends on the ability to withstand oxidative stress. Cells respond to oxidative stress by forming stress granules (SGs), dynamic ribonucleoprotein assemblies driven by the G3BP1 protein. SGs inhibit general protein synthesis while selectively permitting translation of stress-response proteins and protecting other translational components until the stress subsides. Proper SG assembly and disassembly are essential for cellular recovery, and persistent or dysregulated SGs are implicated in some neurodegenerative diseases. Viruses, including human immunodeficiency virus-1 (HIV-1), can manipulate SGs to facilitate viral protein translation. Previous work explored the varying level of oxidative stress-related SG formation in U2OS cells after 40 minutes of treatment with different concentrations of sodium arsenite and treatment with HIV-1 Tat protein. This protein was shown to enhance SG formation under high-stress conditions but had no significant effect at low stress levels, suggesting that HIV-1 Tat modulates SG assembly in a stress-dependent manner. However, while SG number and formation were characterized, the physical characteristics of SG mobility remain unclear. This study expands on prior findings by examining SG mobility using fluorescence recovery after photobleaching (FRAP) in G3BP1-tagged U2OS cells under low and high oxidative stress, with and without HIV-1 Tat protein. Additionally, doxorubicin was used to induce cellular senescence, associated with reduced cytoplasmic fluidity. Because HIV-1 Tat alters SG assembly, it was hypothesized that HIV-1 Tat treatment would reduce SG fluidity. It was also hypothesized that doxorubicin treatment would further reduce SG fluidity due to disruption of the cytoskeleton. Mobility data analysis is currently underway, and quantitative diffusion coefficients will be presented upon completion. This study aims to clarify how viral proteins influence the dynamics of stress granules. The findings could provide insight regarding the mechanisms linking stress granule dysregulation to neurodegenerative pathology.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Brown, Kendall	Riccardi, Nicholas	Mitochondrial Contributions to Accelerated Brain Aging: Associations with Cardiovascular Risk View Full Text Abstract Text As we age, it is increasingly evident that brain health is central to the preservation of overall cognition and function. Data shows increasing correlation of neurological decline and premature mortality. Recently, new techniques have allowed us to map brain age by area, focusing on specific regions where aging is more accelerated. This framework “brain age” uses structural fMRI analysis to estimate brain age by region. Comparing participant scans to healthy age-specific cohorts, allows for analysis of patterns associated with health risks. Cardiovascular risk specifically has been linked to mitochondrial dysfunction and neurological health. Previously, there was no way to measure the influence of mitochondrial profiles on these estimations in vivo. These factors led us to question: do adults with greater cardiovascular risk factors present with accelerated brain aging in mitochondria-rich regions? This study aimed to examine a potential link between adults with higher cardiovascular risk factors and accelerated brain aging in mitochondrial-rich regions. We hypothesized that cardiovascular risk factors relate specifically to aging within mitochondrial rich regions. Utilizing newly published atlases of mitochondrial properties, in combination with structural neuroimaging, we will analyze brain vulnerability in mitochondrial rich regions. Without this research, we lack clarity on contributors to cognitive aging, leaving many with poor health and unanswered questions. We hope that by investigating mitochondrial-focused brain age, we can identify correlations that will aid in the prediction of risk factors and cognitive decline.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Edwards, William	De Backer, Wout Hickey, Patrick	Development and Implementation of an Aviation Tutorial/Checklist for the USC Redbird MCX Flight Simulator View Full Text Abstract Text According to National Transportation Safety Board (NTSB) statistics, approximately 80 percent of all aviation accidents are caused by pilot error, the human factor. Aviation checklists are essential cockpit resources used to verify the aircraft instruments and systems are checked, set, and operating properly, with proper aviation checklist use and optimum aviation checklist design being human factors issues. Flight safety can be enhanced by proper aviation checklist usage and good checklist design. During preflight, a checklist ensures pilots inspect an aircraft’s components and systems for proper operation and structural integrity and allows them to verify airworthiness. Aviation checklists provide important structure to the things pilots check often, usually in a prescribed order of priority, and are a proven way to reduce errors and improve flight safety. However, accidents still occur in which misuse of the checklist or poor checklist design are often contributing factors. The University of South Carolina (USC) has a Redbird MCX Flight Simulator that is used by students in the aerospace engineering undergraduate labs, members of the Carolina Flight Club, as well as many other USC students interested in becoming pilots as it mimics the real-life experience of being in the cockpit of a plane. However, to date there has not been a checklist nor tutorial for students to use when “flying the Redbird”. Lessons learned by using an aviation checklist in a flight simulator can be transferred to a real cockpit as it provides a structured, standardized way to perform critical pre-flight, in-flight, and landing procedures, essentially acting as a memory aid to guarantee no vital steps are missed during flight operations.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Nasiri, Neekan	Matchin, William	Articulatory Precision Links Inferior Frontal Cortical Thickness and Cognitive Performance in Healthy Adult Women View Full Text Abstract Text Age-related cortical thinning in prefrontal regions has been linked to variability in speech production and global cognition. The Inferior Frontal Gyrus (IFG), a core region supporting speech motor planning and executive-language processes, may provide a structural bridge between articulatory precision and cognitive performance. Vowel Space Area (VSA), derived from first (F1) and second (F2) formant frequencies, indexes articulatory dispersion and may reflect functional consequences of neural variation. However, structural and articulatory pathways have rarely been examined jointly in healthy adulthood. Seventy-four healthy adult women (ages 20–78) from the Aging Brain Cohort completed structural MRI, speech production tasks, and the Montreal Cognitive Assessment (MoCA). Cortical thickness of the IFG, pars opercularis (opIFG), was extracted using the volBrain2 pipeline. VSA was computed from repeated productions of corner vowels. Analyses controlled for age, education, and socioeconomic status. OpIFG thickness was positively associated with MoCA (r = 0.284, p = 0.014) and VSA (r = 0.334, p = 0.004). VSA was positively associated with MoCA (r = 0.337, p = 0.003). Bootstrapped mediation analyses (5,000 samples) indicated a significant indirect effect of IFG thickness on MoCA through VSA (95% CI [0.0003, 1.41]), while the direct opIFG–MoCA association was not significant (p = 0.903). The full model explained 23% of variance in MoCA. Findings are consistent with articulatory precision statistically accounting for the association between prefrontal cortical thickness and global cognition, supporting a shared brain–speech pathway in healthy adulthood.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Keys, Olivia	Wyatt, Michael	Fluorescence Polarization Analysis of Abbapolin and Kinase Domain Inhibitor Induced Conformational Changes of Polo-like Kinase 1 View Full Text Abstract Text Polo-like kinase 1 (PLK1), a dimeric protein consisting of a kinase domain (KD) and a phosphopeptide-binding polobox domain (PBD), is a protein kinase associated with mitosis. Previous work has identified PLK1 overexpression in many human cancers with poor prognoses. Additionally, it was found that inhibition of PLK1 and its resulting inference with mitosis can lead to the death of cancer cells. Abbapolins, non-ATP competitive inhibitors developed from a 2-(4-AlkylBenzamido) Benzoic Adid macrophore, bind to the PBD of PLK1. Abbapolins block phosphorylation of TCTP, a target of PLK1. Abbapolins, in addition to antiproliferative effects, show the novel activity of inducing PLK1 degradation, unlike KD inhibitors that have been shown to promote open conformation when bound, facilitating binding to the PBD. Previous work shows that conformational changes of PLK1 during mitosis, caused by the binding of KD inhibitors, results in destabilization and accumulation of PLK1 in mitotic cells. Alternatively, appapolins were shown to stabilize PLK1 resulting in cellular degradation of PLK1. This degradation prevents cells from entering the M phase of mitosis, causing cells to undergo apoptosis. Fluorescence polarization (FP) assays can be used to quantitatively measure binding of competitive inhibitors in relation to that of a fluorescent tag. By designing a fluorescent tag that binds to the PBD of PLK1, compound efficacy can be determined by observing changes in polarization of said tag in the presence of compounds. When the tag is fully bound to the PBD, it is nearly immobilized, resulting in high polarization. However, when the tag is displaced from the PBD by a competitive inhibitor, the polarization is lost. This assay can be used to quantitatively measure the binding of a compound of interest to a protein. This work employs FP assays to elucidate conformational information and behavior of PLK1 when exposed to abbapolins and kinase domain inhibitors.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Furness, Tanner	Brown, Herrick	Botanical Inventory and Monitoring of Frequently-burned Sandhills Floristic Community View Full Text Abstract Text Sesquicentennial State Park is a predominately longleaf pine ecosystem located in the sandhills region of South Carolina. As longleaf pines typically offer more of a canopy cover, the burning of these trees and the pinestraw that covers the forest floor allows for more herbaceous plants to thrive. Prescribed burning is prohibited in this state park due to being landlocked by private property, periodic fires would be a natural part of this ecosystem affording us a unique opportunity to study this environment. The study site was subject to eighteen wildfires over a two year timeframe. The goal of this project was to compare plant coverage and species richness in the affected area to an adjacent unaffected area, while monitoring how secondary succession takes place in this specific ecosystem. This was done by mapping the burned and unburned area with GIS and monitoring plant life within a 15 meter radius of 10 randomly generated points. Through maintaining an active checklist of plants within Sesquicentennial State park, this will both allow comparison and act as a record of plant life for the state park service research management staff. This is the beginning of a long-term project which will continue for five years and will improve our knowledge of South Carolina flora as well as how plots recover after burning in sandhills environments.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Patel, Nidhi	Buckhaults, Phillip Mohseninia, Atefeh Nageswara Rao, Chintada McInnes, Campbell Wyatt, Michael Patel, Shrey	Multiplexed Barcoded Organoid Screening Reveals Genotype-Specific and Tumor-Selective Drug Responses in Colorectal Cancer View Full Text Abstract Text Cancer treatment outcomes vary widely between patients, highlighting the need for models that can predict individual drug responses. Patient-derived organoids (PDOs), grown directly from tumor tissue, preserve key features of the original cancer and provide a platform for functional drug testing. In this study, we applied a lentiviral barcoding strategy developed to uniquely label colorectal PDO lines, enabling pooled screening of multiple patient-derived models while maintaining sample-specific resolution. Using the CloneTracer system, stable DNA barcodes were introduced into 20 tumor organoids and one matched normal control. Following treatment, shifts in relative barcode abundance were used to quantify relative Darwinian fitnesses within pooled cultures. We determined the activity of a KRAS G12D inhibitor MRTX1133 across a mixture of 19 colon tumor organoids and found that, as expected, two organoids harboring KRAS G12D were the most sensitive to MRTX1133. We also determined the activities of PLK1 inhibitors targeting either the ATP-binding site (Onvansertib) or the Polo-box domain of PLK1 (two abbapolins) all three of which showed similar results, identifying two organoids sensitive to PLK1 inhibition. To assess tumor versus normal selectivity, we next performed a pooled tumor-normal comparison using a single tumor (F147T) and its matched normal organoid (F147N) challenged with 24 different oncology drugs. The PLK1 inhibitor Onvansertib, the Proteasome inhibitor Ixazomib and the Topoisomerase inhibitor Idarubicin all showed selective activity against the tumor compared to its matched normal. Collectively, these findings establish pooled barcoded organoid screening as a high throughput strategy for resolving genotype-driven drug responses. By enabling direct internal comparison across genetically distinct patient-derived models, this design enhances detection sensitivity while minimizing inter-sample variability, providing a scalable platform for functional precision oncology.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Simpson, Daniel	Johnson, Christian Odo, Chigozie	Purification of KRAS fast-exchange mutants for nucleotide exchange and SOS-binding assays to characterize mutant KRAS-SOS interactions. View Full Text Abstract Text Small GTPases are a family of proteins responsible for cell signaling and growth in humans. They function as molecular switches, existing in the “on” (GTP-bound) or “off” (GDP-bound) states. KRAS is a small GTPase that regulates the MAPK signaling pathway responsible for cell growth, and mutation of KRAS is implicated in ~10% of all human cancers. KRAS is normally activated by the guanine nucleotide exchange factors (GEF), such as SOS, and are deactivated by GTPase activating proteins (GAP). The uncontrolled upregulation of KRAS activation via mutation leads to uncontrolled cell growth. Mutations can activate KRAS through enhanced nucleotide exchange, decreased GTP hydrolysis, or a combination of both. While direct targeting of KRAS in the clinic has achieved some success, tumors often develop resistance. In response, vertical inhibition strategies targeting the MAPK signaling pathway at multiple nodes (e.g. KRAS and SOS1) have been developed and are currently being explored by the field. We are interested in deciphering the underlying mechanism(s) of mutation-enhanced nucleotide exchange in KRAS, and how it relates to the SOS-catalyzed mechanism of nucleotide exchange. Here, we examine how different fast-exchange mutants of KRAS bind to SOS and influence the kinetics of nucleotide exchange using fluorescent nucleotide analogues and pull-down assays. These studies will help clarify the ways in which SOS1 works with mutant KRAS in the cell to enhance tumor growth, and ultimately, predict whether vertical inhibition of SOS and KRAS is a rationally viable approach for different mutants of KRAS.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Callahan, Liam	Brown, Herrick	Clinal variation in Liriodendron tulipifera in South Carolina View Full Text Abstract Text This undergraduate research project investigates clinal variation in Liriodendron tulipifera across central South Carolina, with the goal of evaluating morphological differences between coastal and piedmont ‘ecomorphs’ and assessing whether these variations may indicate distinct taxa. In order to investigate trends in leaf morphology across environmental gradients, the study integrates morphometric measurements, field observations, and herbarium data analysis. Existing specimen records will be mined using regional herbarium databases, including SERNEC, to identify geographic trends in phenotypic variation. Morphometric analysis will focus on sun-grown leaves to ensure consistency in developmental conditions, allowing for reliable comparison among populations. Springtime fieldwork will evaluate ecological coherence in situ and confirm identified morphological trends in natural populations. Geographic information system tools and relevant primary literature will support spatial and ecological interpretation of results. By integrating historical collections with contemporary field sampling, this project aims to clarify whether observed morphological differences represent continuous environmental variation or evidence of taxonomic differentiation. The research contributes to understanding plant adaptation across environmental gradients and highlights the value of combining herbarium resources with field based ecological investigation.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
DiFondi, Taylor Mangallampalli, Veena	Bradshaw, Jessica Yurkovic-Harding, Julia	Hand–Eye Coordination During Toy Play in Infants at Elevated Likelihood for Autism View Full Text Abstract Text Infant hand-eye coordination (i.e., looking at toys they are touching) plays a foundational role in early development. During these moments, parents can readily align their attention with the infant’s focus, creating opportunities for shared attention and object labelling that support language and social development (Suanda et al., 2016; Yu & Smith, 2012, 2015). Infants who are later diagnosed with autism spectrum disorder (autism) demonstrate differences in how they coordinate visual attention and manual actions during play (Sacrey et al., 2013). However, it remains understudied whether the rate of hand-eye coordination differs for infants at elevated likelihood for autism, potentially shaping early opportunities for social learning. Participants were 41 parent-infant dyads with 8-month-old infants at elevated likelihood (EL, n = 25) or low likelihood (LL, n = 16) for autism. Both infants and parents wore head-mounted eye trackers during a ~10-minute free-play session with toys. Infant look to toys and touch of toys were coded frame-by-frame for the duration of the play session. Hand-eye coordination was defined as frames where infants were looking at a toy that they were simultaneously touching. EL and LL infants showed highly similar patterns of attention and action. Both groups looked at toys for about half of the session (EL: 54% (SD +/- 16%); LL 53% (11%); F(1,39) = 0.15, p = .71) and touched toys for over two-thirds of the session (EL: 69% (19%), LL 71% (17%); F(1,39) = 0.001, p = .97). Critically, the proportion of time spent in hand-eye coordination did not differ between groups (EL: 47% (15%), LL: 42% (11%); F(1,39) = .163, p = .21). These findings suggest that, at 8 months, infants at elevated and low likelihood for autism engage in similar attention and action dynamics during play. The availability of moments that could support shared attention and parental input may then also be similar across groups. Future work will examine whether parent-infant shared attention during these hand-eye coordination moments differs between groups.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Castro, Lexie Stalford, Sophia	Webb, Emily	Arbovirus Surveillance in South Carolina: Monitoring Mosquito Species Diversity and Viral Activity Using State-Level Data View Full Text Abstract Text Mosquito-transmitted arboviruses pose a growing public health concern due to their widespread distribution and ability to cause severe disease in humans and animals. In South Carolina, diverse mosquito species support transmission cycles for pathogens including West Nile virus, Eastern equine encephalitis virus, La Crosse virus, and Cache Valley virus. Surveillance efforts conducted by the South Carolina Department of Public Health have documented the presence of these viruses in mosquito populations and occasional spillover infections in humans and animals. State and local surveillance programs routinely conduct mosquito trapping and viral testing to monitor arbovirus activity and identify periods of increased transmission risk. Seasonal mosquito abundance, combined with environmental factors such as rainfall and temperature, creates conditions conducive to arbovirus transmission. In addition, migratory birds play a critical ecological role in maintaining and dispersing certain arboviruses, particularly West Nile virus, through enzootic bird–mosquito transmission cycles. This project presents a descriptive analysis of state-level surveillance data examining mosquito species diversity, infection monitoring, and reported arbovirus detections in mosquito pools, humans, and animals. By summarizing current mosquito surveillance data, this work highlights the importance of sustained vector monitoring for guiding mosquito control strategies and improving public health awareness in South Carolina.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Stone, Brea Davis, Hudson	Goldberg, Kelly	Peeking Beneath the Rust: Re-evaluating USC’s History Through Metal Artifact Analysis View Full Text Abstract Text The muddled history of the University of South Carolina can be better understood through the use of archaeology and a variety of preservation techniques. Through the analysis of metal artifacts recovered from USC’s historic Horseshoe using the process of electrolysis, which uses electrical currents to create a chemical reaction in metal, breaking down rust to reveal the original object underneath, we hope to expand the dominant narrative about the history of the University. This will uncover information about the activities of the people who used to live and work there. Following electrolysis, we will engage in metal preservation processes to allow for the continuation of long-term analyses and research. With the expansion of USC, history has been incrementally erased through the construction of modern buildings over historic ones. As a result, certain narratives have been neglected, including those of enslaved people on campus, forming gaps and affecting the knowledge that can be considered common about USC’s history. Analyzing these metal artifacts can help determine labor patterns and migration patterns of the university’s workforce and add to the perspectives available of people from the 19th century to develop our view of university life within the context of this time period. We predict that this research will begin to bridge the gap of USC’s undocumented history.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Adair, Taylor	Armstrong, Bridget Culverhouse, Josh Restino, Meghan Bowen, Kaia	Comparing Methods for Measuring Smartphone Screen Time: Passive Sensing and Screenshot Reports View Full Text Abstract Text Background: Accurate assessment of smartphone use is critical to examine associations between health outcomes and screentime. Prior research has relied on self-report measures prone to reporting bias. Recent approaches include screentime screenshots and passive sensing applications implemented to improve accuracy. Screenshot collection requires participant effort and staff oversight, increasing burden and potential data loss. While passive sensing may reduce participant burden, it requires preprocessing decisions that influence resulting estimates. This study examines how different preprocessing approaches for passive sensing data compare with screentime screenshots in estimates of daily screentime duration. Methods: We analyzed 433 days of Android smartphone passive sensing data and daily screenshots from 39 participants. Passive sensing data were preprocessed using three methods (Uzair, Parry+Toth, and EYEs), each applying rules to identify complete days of data and summarize daily screentime from raw usage logs. Agreement between passive sensing and screenshot-reported daily screentime was assessed using Bland-Altman plots. Mean difference, standard deviation, and 95% limits of agreement (LoA) were used to evaluate comparability between measures. Results: Using the Uzair method the mean difference (screenshot minus passive sensing) was 8.78 minutes (SD=37.78; LoA -65.26 to 82.82), indicating slightly higher values from screenshots. The Parry+Toth method resulted in mean difference of -17.91 mins (SD=45.37; LoA -106.84 to 71.02), while the EYEs method resulted in mean difference of 33.7 mins (SD=52.0; LoA -68.3 to 136). Conclusion: Across methods, bias between passive sensing and screenshots were small, but LoAs were wide., Screenshots cannot be assumed to represent a gold standard, as device algorithms are not fully transparent. In the absence of a definitive ground truth, preprocessing decisions substantially influence daily screentime estimates. Despite providing objective usage logs, passive sensing requires careful processing due to missing data and device-level differences, underscoring the need to evaluate whether screenshot collection is warranted.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Mullinax, Chloe	Pettay, Tye	Characterization of Pond Functioning on Spring Island View Full Text Abstract Text Spring Island in Okatie, SC is an ecologically coconscious private community that maintains a high standard for natural landscape and wildlife protection. They conduct numerous projects including monitoring and maintaining ponds around the island for various uses such as recreational fishing, sightseeing, and overall pond and land health. The ponds may be exposed to contaminants from wildlife and human runoff. During the summer of 2025, we consistently monitored the conditions of 9 ponds around the island in relation to the water health in relation to its surrounding environment. To visually show the weekly condition with the water temperature we graphed the different parameters and water temperature in correlation with each other. Sampling data sets were from the recent school year as well as the past two summers.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Quartaro, Elise	McQuail, Joseph	Differential Effects of Chronic Stress on Working Memory Performance and Locus Coeruleus Neurons in Aging Rats View Full Text Abstract Text The locus coeruleus is an area of the brainstem rich in norepinephrine-containing neurons. Norepinephrine is responsible for arousal, and increases alertness and attention. The concentration of LC-NE neurons has been positively correlated with working memory performance, while stress is associated with increases in norepinephrine. Large increases in norepinephrine are detrimental to working memory, but moderate increases are associated with improvements in working memory. Meanwhile, age-related deterioration of the locus coeruleus may decrease norepinephrine, leading to declines in working memory performance. Thus, we hypothesized that chronic variable stress affects working memory performance and causes changes in LC-NE neurons in an age-dependent fashion. Male and female Fischer 344 rats were obtained and tested at 6 and 24 months of age. Rats in the chronic variable stress sample were exposed to a stressor twice daily: either a forced swim in 15 or 25°C water, bobcat or coyote urine, cage flood, or 1-hour physical restraint. To test working memory, they performed a delayed match-to-sample task, with performance being measured as a percentage of correct trials. Chronic stress increased choice accuracy in aged males, but had no effect on aged females. Additionally, across all conditions, females had a higher average choice accuracy than males. Following these protocols, brain tissue was harvested from rats in each group. The brainstem was sectioned and LC-NE neurons were visualized using antibodies raised against tyrosine hydroxylase. TH+ neurons were counted manually using a microscope. Preliminary results suggest that TH+ cells were fewer in stressed rats than unstressed rats, with no difference between age groups. Our results support our hypothesis that stress differentially affects working memory across lifespan with impacts at the level of the LC. Future studies could investigate if stress-related changes to the locus coeruleus are correlated to activation, neurodegeneration or neural inflammation, using c-Fos, NeuN and Iba+ staining.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Lawrence, Madeline	Coulombe, Brianne	Caregiver Marijuana Use, Psychologically Aggressive Parenting, and Childhood Aggression View Full Text Abstract Text Caregiver substance use is related to a host of negative outcomes in and beyond childhood (e.g., psychopathology, academic problems, etc., Velleman, 2016). Marijuana use by caregivers predicts child aggression (Wesemann et al, 2022). One mechanism of this association may be the use of psychological aggression (i.e., threatening or demeaning language) in discipline. Caregivers who use marijuana are more likely to use psychological aggression towards their children (Wesemann et al., 2022). The impact of psychological aggression on child aggression is less clear, as many studies evaluate psychological and physical discipline tactics together (Bozzay et al., 2020). The current study evaluated a mediation model wherein caregiver marijuana use was expected to predict elevations in psychologically aggressive discipline and greater aggressive behavior across middle childhood (i.e., age 4-10). Participants were 250 child-caregiver dyads from a longitudinal study of child development. When children were 4, caregivers reported the number of times they used marijuana in the past year (M = 2.11; SD = 1.46). When children were 4 and 6, caregivers reported frequency with which they used psychological aggression in discipline (i.e., threatened to send your child away) using the Parent-Child Conflict Tactics Scale (Strauss et al., 1979). When children were 10, caregivers reported their child’s aggressive behavior using the Reactive-Proactive Aggression Questionnaire (Dodge & Coie, 1987). Mediation analyses conducted in Hayes’ PROCESS revealed a significant indirect effect of caregiver marijuana use on child aggression via psychologically-aggressive discipline (B = 0.010, SE = 0.006, 95% CI [0.001, 0.247]). Analyses controlled for socioeconomic status, gender, prior psychological aggression, and prior child aggression. The current study highlights psychologically-aggressive discipline as a pathway by which caregiver marijuana use eventuates negative outcomes for children. Existing research has focused primarily on other forms of abuse (i.e., physical, neglect; Tucker, 2022).This study offers evidence that psychological aggression should be considered equally for child-wellbeing.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Lieberman, Madeline	Deflem, Mathieu	AI and Academic Integrity: A Review of University Policies View Full Text Abstract Text The rapid adoption of artificial intelligence (AI) in higher education has expanded learning support and instructional tools while complicating long-standing norms of academic integrity. This research surveys existing institutional policies on AI and academic integrity at various universities, including the University of South Carolina, its peer and peer-aspirant institutions, and additional SEC-member schools. Data were primarily collected by means of targeted searches on university websites and, if no information was found, via a search on Google. Relevant policy webpages were saved as files organized per individual university. If additional information was needed after this initial search, emails were formally sent to deans, offices of academic integrity, offices of provost, and even the student affairs office. Some deans and offices replied with additional information or information that had already been found. These emails were also saved in files organized by universities. Results of the data collection revealed two dominant policy approaches: 1) academic integrity frameworks that reference AI but delegate allowable use to individual instructors (often supported by sample syllabus language or tiered permission scales); and 2) university-wide expectations that presume AI is not permitted for coursework unless explicitly authorized by an instructor. Across the SEC and nearby peer institutions, strict blanket prohibitions were uncommon. Most schools emphasize instructor clarity, student disclosure, and alignment with existing misconduct categories (e.g., plagiarism, falsification). Overall, findings suggest universities are actively negotiating a shifting boundary between legitimate assistance and misconduct, with policy clarity and instructor communication emerging as central mechanisms for maintaining academic honesty.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
DePratter, Dawson	Alshareef, Ahmed	Biofidelic Phantom Headform Model for Traumatic Brain Injury View Full Text Abstract Text Traumatic Brain Injury (TBI) impacts approximately 69 million people globally each year, frequently resulting from high-impact sports collisions or automotive accidents. A tool to evaluate the effectiveness of safety equipment is physical headform phantoms that measure intracranial kinematics. However, current industrial headforms often oversimplify the brain-skull interface, neglecting the internal dynamics necessary for precise kinematic measurements. The objective of this study is to develop a more anatomically biofidelic 3D-printed phantom headform to serve as a high-fidelity tool for physical impact testing. By utilizing computer-aided design (CAD), we built a finite element (FE) mode of the brain-skull interface using known volume fractions of the trabeculae within the subarachnoid space and detailed thicknesses of the surrounding meningeal layers—the dura, arachnoid, and pia mater—to better mimic real-world cerebral tissue kinematics. Soft 3D-printed materials were selected based on mechanical testing of a specialized FormLabs 50A silicone resin in tensile to ensure its behavior aligns with human brain tissue. Material data was analyzed using LS-Dyna finite element modeling and compared against experimental brain-skull interface literature. Following iterative design adjustments to optimize 3D printing supports and subsections, the final headform will be assembled with a brain stimulant and strategically placed sensors. This innovation will eventually be tested using a blunt force and analyzed to provide an accessible, accurate surrogate that can enhance laboratory testing for TBI, ultimately informing the development of superior protective devices for athletes, automotive safety, and military personnel.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Ottone, Brennan	Jasnow, Aaron	Cholinergic signaling in the anterior cingulate cortex influences the formation of contextual memory indexes in the hippocampus View Full Text Abstract Text Hippocampal indexing theory proposes that episodic memories are encoded as indexes that bind unique neocortical ensembles representing the features of an experience. The hippocampus (HPC) does not store the entire contextual memory locally; instead, it forms a relational index linking regional cortical representations. This enables retrieval later through pattern completion. The precision of index formation during encoding is critical for subsequent contextual discrimination and has implications for memory specificity and accuracy. We tested whether cholinergic signaling in the anterior cingulate cortex (ACC) influences HPC contributions to contextual memory specificity during fear encoding. Mice were pre-exposed to context B and subsequently fear-conditioned in a novel context A. Before conditioning in context A, animals received either vehicle, the non-selective muscarinic antagonist scopolamine, the specific M1 receptor antagonist VU255035, or the non-competitive nicotinic acetylcholine receptor (nAChR) antagonist mecamylamine. Manipulations of muscarinic receptors had a minor effect on fear acquisition but had no effect on fear recall when mice were tested in either context. When mecamylamine was infused locally in the ACC, there was no difference in fear acquisition. However, during a subsequent test in context B, mecamylamine-treated mice exhibited significantly greater freezing than vehicle controls, indicating reduced contextual discrimination and a less precise contextual memory. Within an indexing framework, these findings suggest that cholinergic signaling in the ACC through nicotinic receptors during encoding contributes to the formation of a precise contextual index. Disruption of this signaling degrades contextual specificity, increasing representational overlap between contexts A and B and promoting generalization at test. We are currently examining the representation of the hippocampal index using the neuronal activity marker c-Fos. We hypothesize that mice treated with mecamylamine will show a more restricted pattern of c-Fos expression, reflecting greater ensemble overlap.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Baker, Mariel Perdomo, Ashley	Webb, Emily	Eastern Equine Encephalitis Virus: Pathogenesis, Epidemiology, and Public Health Implications View Full Text Abstract Text Eastern equine encephalitis virus (EEEV), also known as “Triple E,” is a highly virulent mosquito-borne virus endemic to areas along the Atlantic and Gulf coasts of the United States. Although human infections are relatively rare, the disease can cause severe neurological illness and carries a high mortality rate in both humans and animals. Infection occurs when mosquitoes transmit the virus from enzootic bird reservoirs to humans or other mammals. Following infection, viral replication and immune-mediated inflammation can lead to encephalitis and significant neurological damage. Recent evidence suggests that environmental changes, including climate change, may be contributing to an expansion of the virus’s geographic range by altering mosquito distribution and increasing vector populations. Because no approved antiviral treatments currently exist for EEEV, preventative measures such as virus surveillance, vector control, and public health awareness remain critical. This project reviews the pathogenesis and epidemiology of EEEV while examining historical surveillance data and environmental factors that may influence transmission risk. Understanding these factors is essential for identifying high-risk regions, informing mosquito control strategies, and improving public health preparedness.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Motte, Jordan	Stodden, David	Comparison of TOPS and PMC Profiles in ROTC Cadets View Full Text Abstract Text Psychological skills and well-being are important for successful military careers. Need fulfillment of psychological skills has been linked to high perceptions of competence and autonomy in military training, but less is established in the context of Reserve Officers’ Training Corps (ROTC). Previous research has confirmed a relationship between fundamental motor competence and Army Combat Fitness Test (ACFT) that helps ROTC programs assess how a cadet will perform on the ACFT based on their motor competence. The goal of this study is to examine associations between perceived motor competence (PMC) and the Test of Performance Strategies (TOPS). The present study will examine different profiles of TOPS and PMC data in ROTC cadets at a Military College and a large university in the Southeast US. The Test of Performance Strategies (TOPS) is a self report questionnaire that examines athletes’ use of sixteen psychological skills across practice and competition settings. This study focuses on four of the subscales: goal setting, activation, relaxation, and emotional control. Each item is scored on a five point Likert response scale, where a five means more frequent use of skills, and a one means no use of skills. Another self report questionnaire examines perceived motor competence on a six point Likert response scale, where six means very true and one means very false for questions about perception of performance. Our hypothesis is that reported skills in TOPS and reports of perception of performance will have similar relationships across the profiles of TOPS and PMC data in ROTC cadets. Findings can inform ROTC programs on psychological needs that may need to be met and whether enhancing PMC may be a useful focus area to improve performance and military readiness.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Maloney, Julia	Fillo, Jennifer Blakley, Morgan	Secondary traumatic stress among U.S. military spouses: Relations with mental health, substance use, and relationship functioning View Full Text Abstract Text Secondary traumatic stress (STS) is the presence of symptoms similar to posttraumatic stress disorder (PTSD) which result from being indirectly exposed to the traumatic experiences of others. Despite extensive research on the consequences of trauma among military service members, there is limited data on how this exposure impacts spouses. The present research examined (1) the prevalence of STS among military spouses, and (2) relations between STS and spouse mental health, substance use, and relationship functioning. Data were drawn from a study examining health among U.S. Army Reserve/National Guard soldiers and their partners. The analytic sample included female spouses with no prior military history (N=320). STS was defined as the presence of PTSD symptoms above an established threshold (PCL-5 scores ≥31) without ever personally experiencing a traumatic event. Regression analyses examined relations between PTSD symptoms and mental health, substance use, and relationship functioning variables, controlling for service member PTSD symptoms, years of military service, and the service member’s equivalent score on the outcome variable. For civilian spouses with no prior traumatic event (N=119), 76.5% reported some degree of PTSD symptoms. Of these spouses, 9.2% met criteria for probable PTSD. Among civilian spouses without a prior traumatic event, their PTSD symptoms predicted greater depressive symptoms, anxiety, and anger. Spouse PTSD symptoms predicted higher alcohol use, more frequent heavy drinking, greater alcohol use problems, and higher likelihood of tobacco use. Additionally, spouse PTSD symptoms predicted lower marital satisfaction. Results revealed strong evidence of STS among military spouses. Nearly 1 in 10 civilian spouses met criteria for probable PTSD without having experienced their own traumatic event. These symptoms were associated with a range of negative mental health, substance use, and relationship functioning outcomes. Further research using dyadic approaches to study military-related trauma may benefit the future care of service members and their families.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Cargill, Michael	De Backer, Wout	Robotic Large Format Additive Manufacturing for On-Demand Tooling for Composites View Full Text Abstract Text The increasing use of carbon fiber reinforced polymers (CFRPs) in aerospace and advanced manufacturing has created significant demand for tooling that can withstand composite fabrication processes. Traditional tooling materials provide dimensional stability and durability but are associated with high costs ($5,000 to over $100,000) and lead times that can extend from months to years. This project investigates the feasibility of using robotic large-format additive manufacturing (LFAM) to produce polymer-based composite tooling as a lower-cost, rapid alternative. Leveraging the University of South Carolina’s pellet-fed, single-screw extruder mounted on a Kuka KR60 robotic manipulator, this research evaluates the performance of 3D-printed polymer molds for complex curved composite structures. The study addresses three primary questions: whether printed polymer tooling can withstand composite manufacturing processes, how the resulting composite quality compares to that produced with traditional tooling, and which design and process parameters most significantly influence tool performance. The methodology consists of three phases: tool manufacturing, composite manufacturing, and comparative analysis. A tooling geometry will be designed, tool-pathed, printed using LFAM, and CNC-finished to final dimensions. Both the printed and traditional tools will then undergo identical composite manufacturing processes. Performance metrics will be measured to benchmark printed tooling against conventional methods. It is anticipated that polymer-based tooling will demonstrate functional viability with minor reductions in quality compared to traditional tooling, while offering substantial reductions in cost and lead time. This research aims to expand in-house composite manufacturing capabilities and contribute to more accessible, responsive tooling solutions for aerospace applications.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Zahn, Jacob	Shtutman, Michael	Production and Quantification of EcoHIV: A Rodent-Specific Model of HIV Infection View Full Text Abstract Text Despite advances in antiretroviral therapy (ART), HIV infection remains a significant global health problem. More than 40 million people live with HIV worldwide, and new infections continue to occur yearly, including hundreds of cases annually in South Carolina. Although ART effectively suppresses viral replication, people living with HIV still experience an increased risk of long-term complications such as cardiovascular disease, neurocognitive decline, and reduced life expectancy. Understanding the biological mechanisms underlying these complications requires experimental models that allow investigation of HIV infection at the organismal level. However, HIV does not naturally infect rodents, limiting the use of conventional mouse models for in vivo studies. To address this limitation, EcoHIV, a modified HIV variant capable of infecting rodent cells, was developed. In EcoHIV, the viral envelope required for cell entry is replaced with the envelope protein from ecotropic murine leukemia virus, allowing infection of rodent cells while preserving essential aspects of HIV biology. Reliable production and quantification of EcoHIV viral stocks are therefore critical for experimental studies. In this project, we established a reproducible workflow for EcoHIV production and purification. EcoHIV plasmid DNA was amplified in NEB Stable Escherichia coli and purified using an endotoxin-free plasmid preparation. The purified plasmid was used for transient transfection of HEK 293FT cells at approximately 60% confluency. For each 100-mm dish, 6 µg of EcoHIV plasmid DNA was complexed with polyethyleneimine prior to addition to cells. Viral supernatants were collected, clarified by 0.45 µm filtration, and concentrated by centrifugation at 4 °C. For accurate viral titer quantification, we established a digital PCR (dPCR) assay using four fluorescent probes targeting distinct regions of the viral genome. By partitioning samples into thousands of nanoliter reactions and applying Poisson statistics, dPCR enables absolute quantification of viral genomes without standard curves, providing precise and reproducible measurement of EcoHIV titers.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Patel, Bhumika Abdalla, Jafar	Strohmier, Hala	Using Deep Learning to Detect Pixel-Level Tampering in X-Ray Images View Full Text Abstract Text Recent advances in algorithmic photo-editing combined with hospitals' vulnerability to cyberattacks raises concerns about the tampering of medical images. This study proposes a cloud-based deep learning framework for multi-class tampering detection in grayscale X-ray images using residual convolutional neural networks. Five image categories were assessed: clean, blur, copy-move, noise, and splice manipulations. Two architectures, ResNet18 and ResNet50, were compared. Class imbalance was mitigated by weighted cross entropy loss and weighted sampling. The optimized Reset50 model achieved test accuracy of 74.22 and macro-F1 of 0.6195 across five classes. The results show that residual networks are able to effectively detect structured tampering artifacts from image data without having to rely on metadata. However, subtle degradations such as blur are still hard to detect. The framework sets out a scalable architecture on which AI-based medical image integrity verification can be built.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Reed, Ainsley	Meekins, Benjamin Likit-anurak, Kris Shimpalee, Sirivatch	Acid Loss and Electrochemical Durability in PBI Membranes Under Continuous Operation at High Current Density View Full Text Abstract Text Continuous high-current density operation was conducted to evaluate phosphoric acid loss and electrochemical durability of a Celtec-Z polybenzimidazole (PBI) membrane in a high-temperature hydrogen fuel cell. The membrane was operated at a constant current density of 1 A/cm² with daily performance monitoring performed throughout extended operation. At regular intervals, cell potential (V) and high-frequency resistance (HFR, mΩ) were recorded, and effluent water volumes from both anode and cathode outlets were collected and measured to assess stability, conductivity behavior, and acid transport characteristics. Phosphoric acid concentration in collected water samples was analyzed to quantify membrane acid loss during continuous operation. Electrochemical data demonstrated a slight increase in cell voltage over time, with no significant performance degradation observed under the sustained load. HFR measurements showed a gradual decrease throughout operation, suggesting improved ohmic behavior and stable membrane conductivity under continuous high-current conditions. These combined electrochemical and analytical measurements provide insight into acid retention behavior and membrane durability under prolonged high-current operation.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Long, Lauren	Klusek, Jessica Christensen, Thomas Jenner, Lauren	“The child has to drive all of the decisions you make” - How Mothers of People with Fragile X Syndrome Navigate Parenting in Low Resource Areas View Full Text Abstract Text Between 55 and 200 CGG repeats on the Fragile X Messenger Ribonucleoprotein 1 (FMR1) gene is known as the FMR1 premutation (FXpm). FXpm women can pass on a full FMR1 mutation of over 200 CGG repeats to their children, resulting in fragile X syndrome (FXS), the leading inherited cause of intellectual disability. Mothers are frequently the primary caregivers for their sons or daughters with FXS throughout their life, including adulthood. Additionally, living in neighborhoods with fewer resources can create barriers that influence caregiving demands and complicate future planning. This study explores how FXpm mothers residing in low socioeconomic neighborhoods navigate caring and planning for their adolescent and adult sons or daughters with FXS. Interviews were analyzed for seven FXpm mothers aged 44-66 years (M=60 years) who had children with FXS (n=12; aged 16-38 years; M=30 years) and lived in a neighborhood with an Area Deprivation Index in the lowest quartile. The interviews focused on the current care of their son or daughter, future planning, and challenges with caregiving. Interpretative phenomenological analysis was used to identify personal and group experiential themes. Five group experiential themes were identified, which are 1) tension between supporting independence and recognizing limitations, 2) balancing conflicting identities as a mother, caregiver, advocate, and carrier, 3) facilitating community inclusion despite barriers to belonging, 4) reliance on institutional services despite ongoing frustrations, and 5) preparation of child’s long-term care despite uncertainty and anxiety. These themes give insight into how FXpm mothers who live in low resource neighborhoods manage current and future caregiving. The findings reveal potential disparities that highlight the need for targeted support for mothers in resource-limited areas. Future longitudinal research is necessary to study how caregiving and long-term plans evolve as mothers and children age, in order to develop interventions that address social and economic barriers.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Nallu, Sai Varun	Grillo, Claudia Withers, Hayden Maciejewska, Natalia Woodruff, Jennifer Reagan, Lawrence	Effect of Ginseng on Food Intake, Body Weight, and Neuroinflammation View Full Text Abstract Text Over the past 20 years, the prevalence of obesity has risen dramatically, contributing to a parallel increase in metabolic comorbidities, including cardiovascular diseases, type 2 diabetes, and major depressive disorder. Nearly 43% of individuals with depression are obese and adults with depression are more likely to be obese than adults without depression. However, the biological mechanisms linking obesity to depression remain unclear. Recent evidence implicates chronic neuroinflammation as the central connection. Obesity activates microglia, the central immune cells, leading to the release of pro-inflammatory cytokines and subsequent neuronal dysfunction in brain regions critical for mood regulation and energy homeostasis. This project investigates whether Ginseng, a natural herb known for its anti-inflammatory properties, can attenuate obesity-induced neuroinflammation and thereby improve metabolic and neurological outcomes. Using a diet-induced obesity model, male rats were maintained on either a high-fat diet (45% kcal fat) or a control diet (10% kcal fat) for 12 weeks to establish an obese phenotype. Following this period, animals were assigned to four treatment groups: control diet with vehicle (Con-Veh), control diet with Ginseng (Con-G), high-fat diet with vehicle (HFD-Veh), and high-fat diet with Ginseng (HFD-G). After treatment, brains were collected and processed for immunohistochemical analysis. Microglial activation was assessed in the arcuate of the hypothalamus using ionized calcium-binding adapter molecule 1 (Iba1) staining. Microglial morphology was analyzed with Neurolucida software. Under physiological conditions, microglia exhibit small cell bodies and highly branched processes. In contrast, neuroinflammatory states induce an amoeboid morphology with enlarged somas and retracted processes. We hypothesize that obesity will increase microglial activation and morphological simplification, whereas Ginseng treatment will promote a shift toward an anti-inflammatory phenotype. We anticipate that Ginseng-treated obese rats will exhibit reduced microglial activation, supporting the hypothesis that targeting neuroinflammation may represent a novel therapeutic strategy for obesity-associated depression.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Predmore, Amelia Pinter, Luke	Parker, Mickey	Assessing Herpetofaunal Diversity in an Urban Habitat Fragment in Columbia, SC View Full Text Abstract Text Because urbanization dramatically reduces and fragments habitats, it is critically important to examine the role habitat fragments play in harboring biodiversity within urban areas. Located in Columbia, South Carolina, the W. Gordon Belser Arboretum is an approximately 3-ha plot of land owned by the University of South Carolina (USC) that sits approximately 5.6 km from campus. The arboretum is surrounded by a suburban matrix and contains 10 plant communities, including upland forest and a bald cypress swamp. The mission of the Belser Arboretum is to serve as an outdoor laboratory for USC students, function as a conservation outreach center for the community, and maintain a wildlife preserve within metropolitan Columbia. An undergraduate-led project to quantify herpetofaunal diversity at the arboretum using coverboards and visual encounter surveys has been on-going since April 2024. To date, we have documented five lizard species, two snake species, one turtle species, two anurans, and three caudates at the site. To examine how the Belser Arboretum is preserving herpetofaunal diversity within metropolitan Columbia, we compared the species diversity of the Belser Arboretum with that of the greater region of Lexington and Richland Counties in South Carolina, using data from iNaturalist. Our analyses focused on lizards and amphibians found in the region as they are the most commonly found taxa at the Belser Arboretum. We also discuss how our project is contributing to the education and outreach goals of the arboretum.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Taylor, Sarah	Wood, Susan Hollis, Fiona Philbeck, Timothy Thomas, Lillian Smiley, Cora Spinale, Francis	Gestational witness stress results in long term alterations in cardiovascular health through persistent vagal withdrawal. View Full Text Abstract Text Maternal morbidity is strongly associated with both postpartum depression (PPD) and cardiovascular disease (CVD), potentially caused by stressors during pregnancy, however, mechanistic links remain unknown. This preclinical study examined the effects of gestational psychosocial stress on cardiovascular health in rats. Time-mated pregnant and virgin female Wistar rats were assigned to control or five days of witness stress (WS, 15 mins/day), a modified social defeat paradigm, on gestational days 8-12. All rats were implanted with cardiovascular transmitters to investigate autonomic function by analyzing the change in heart rate variability (RMSSD), a marker of vagal tone throughout the peripartum period. Cardiac function was assessed by echocardiography on postpartum days 14 and 22. We hypothesized that WS would negatively alter autonomic function, leading to cardiac strain, with exaggerated effects in peripartum periods. We previously identified that WS induced behavioral changes predominately in postpartum females, suggesting dysfunctional maternal care and impaired habituation to stress. This study extended these findings by identifying the associated cardiovascular changes. Blood pressure (mmHg change from baseline, virgin: Con 1.3± 2.56, WS 9.4±1.8; pregnant: PCon 12.4± 4.7, PWS 17.5±1.6; p<0.05) and heart rate reactivity (bpm change, virgin: Con 60±8, WS 75±14; pregnant: PCon 74±9, PWS 111±14, p<0.05) during WS was exacerbated in pregnant females compared with pregnant controls and virgin rats (p<0.05). WS also increased left atrial area (p=0.01; WS 18.5% increase vs Con, and PWS 30.2% increase vs PCon), a marker of diastolic dysfunction. Strikingly, in virgin females, under resting conditions, previously stressed rats showed a marked decrease in the percent change of RMSSD compared to controls, which showed an adaptive increase (CON: 7.25%±2.6 vs. WS: -9.35%±2.6; p=0.0007). Analysis is underway to understand if vagal withdrawal is exacerbated in postpartum WS rats. These findings point towards gestation as a period of heightened stress sensitivity that may increase PPD-CVD risk.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Green, Luci	Tang, Chuanbing Mathwig, Alexandra Zhao, Hai	Characterizing sustainable copolymers of α-methylstyrene and ethyl vinyl ether View Full Text Abstract Text Copolymers derived from simple organic monomers offer a promising and sustainable alternative to commodity plastics. Their inherent degradability enables optimization of recycling and reuse within a closed-loop economy. Their performance can be evaluated through measurements of molecular weight and thermal properties. α-Methylstyrene (AMS) is a commercially available monomer with a low ceiling temperature (~61 °C), which makes it a suitable candidate for designing recyclable materials. In this work, homopolymers and copolymers of AMS and ethyl vinyl ether (EVE) were synthesized at varying molar ratios using controlled cationic polymerization. The resulting polymers were characterized using nuclear magnetic resonance (NMR) spectroscopy, gel permeation chromatography (GPC), and differential scanning calorimetry (DSC). Several depolymerization methods were carried out with different Lewis acids, and the resulting degradation products were analyzed using NMR spectroscopy and GPC. The results demonstrate that AMS–EVE copolymers exhibit a relatively low glass transition temperature (Tg) while maintaining high degradability.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Patel, Shreena Cohn, Jake	Smith, Deanna	Can Missense Mutations in LIS1 Cause Autism? View Full Text Abstract Text The PAFAH1B1 gene encodes LIS1, a regulator of microtubule (MT) motor protein, dynein, which is vital for cell division, migration, and intracellular transport. LIS1 enhances dynein activity by stabilizing its open conformation, promoting interactions with dynactin and cargo adapters, and increasing the number of motors attached to a cargo, resulting in longer and faster runs overall. Mutations in PAFAH1B1 cause lissencephaly, a severe neurodevelopmental disorder characterized by reduced life expectancy and motor and cognitive disabilities. There have been no other neurological disorders linked with LIS1 mutations; however, a patient with Autism Spectrum Disorder (ASD) at the Greenwood Genetics Center was found to have a K351R missense mutation in LIS1, with no changes in 50 other ASD-linked genes. This patient did not have lissencephaly, suggesting the possibility that altered LIS1 function could contribute to ASD. Most, if not all, LIS1 functions are related to its ability to regulate dynein, so our current research aims to determine the effects of the K351R mutation on the physical and functional interaction between LIS1 and dynein. We used AQ5 mutagenesis to generate the K351R mutation in WT GFP-tagged LIS1 in the pEFGP-C1 plasmid. COS7 cells were transfected with these constructs, and K351R-LIS1 and WT-LIS1 were observed by GFP fluorescence. The GFP-plasmid alone was used as a control for effects of GFP expression. As reported previously, expression of WT-LIS1 results in an accumulation of dynein at centrosomes due to increased dynein movement along MTs. Unexpectedly, expression of K351R-LIS1 was more effective than WT-LIS1 at inducing centrosome accumulation suggesting hyperactivation of dynein. We will next determine if K351R-LIS1 binds more efficiently to dynein and whether it impacts known dynein functions in neurons and glia. We successfully expressed constructs in cultured mouse astrocytes and will soon express in cultured cortical neurons.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Murphy, Jacqueline	Kathrein, Katie Marchione, Alissa	Combined Effects of Curaxin and Rapamycin on ING4-Deficient Colorectal Cancer View Full Text Abstract Text Cancer remains well-studied in the world of disease research due to its rapid growth, complicated nature, and difficulty in treating. Many of these cancers exhibit stem cell characteristics that enable cell proliferation beyond normal limits. Loss of the tumor suppressor inhibitor of growth 4 (ING4), a chromatin-associated regulator within the HBO1 histone acetyltransferase complex, is observed in multiple malignancies and is associated with tumor progression and therapeutic resistance. RNA sequencing of ING4-deficient primary tumors and cancer cell lines reveals enrichment of pathways associated with metabolic activity and cellular proliferation, including oxidative phosphorylation, ribosomal biogenesis, mTOR, and MYC signaling. Preliminary studies using ING4 knockdown zebrafish models further demonstrated that treatment with small-molecule NF-κB inhibitors restored hematopoietic stem and progenitor cell specification, supporting a conserved role for ING4 in transcriptional regulation. Building on these findings, we evaluated targeted inhibition strategies in ING4-deficient colorectal cancer cell line (HCT116) using Curaxin (NF-κB pathway inhibitor) and rapamycin (mTOR inhibitor). High-dose single-agent treatment reduced colony formation and cell viability in vitro and decreased tumor burden in zebrafish xenograft models. Notably, combination treatment achieved comparable antitumor effects at lower concentrations, consistent with a synergistic interaction. Together, these findings indicate that coordinated targeting of NF-κB signaling and downstream metabolic regulators represents a promising therapeutic strategy for malignancies characterized by ING4 deficiency and highlight a broader role for ING4 in maintaining transcriptional and metabolic homeostasis during tumorigenesis.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Gacsy, Griffin	Burns, Andy	Evaluating How Mexican News Outlets Uphold The Principles of Journalism View Full Text Abstract Text This project analyzes how Mexican news organizations demonstrate the core values of journalism. Through processing multiple forms of media in Mexico, I will examine how the practice of reporting follows values such as objectivity, independence, and credibility, while also observing how other factors like journalist safety, including the threat of cartels, and freedom from power affect their news coverage.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Carleton, Kaya	Mcquillin, Samuel	The Relationship Between the Knowledge and Engagement of Healthy Sleep in University Students View Full Text Abstract Text Adequate sleep is necessary for cognitive functioning, emotional regulation, academic performance, and physical health, however many college students report inconsistent and poor quality sleep. While many authorities encourage healthy sleep behaviors, such as consistent sleep schedules and limited screen time, we are unsure whether students are promptly uninformed on these topics, or if this is the result of other variables, such as ignorance or inability to implement such behaviors. This study aims to understand the relationship between college students knowledge of healthy sleep practices and their engagement in such behaviors. Using an online questionnaire, undergraduate students will be evaluated on their sleep habits, bed time routines, and knowledge of healthy sleep practices. The data will be analyzed using correlational analyses to determine the strength of the relationship between knowledge and engagement. The results of this study will show if the problem behind lack of healthy sleep in college students is due to a lack of information, or if there are other variables affecting student’s engagement in healthy sleep. Using this information we can conduct further studies on the best way to implement healthy sleep behaviors in University students.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Kordamiri, Arshaam	Hollis, Fiona Wood, Susan Spinale, Frank	Effects of gestational stress on long-term cardiovascular health in female rats View Full Text Abstract Text While maternal mortality is decreasing in the western world, the United States continues to have the highest rate among high-income countries. Maternal health faces significant challenges in the United States, with cardiovascular disease (CVD) as the leading cause of pregnancy-related deaths. Stress is a known risk factor for CVD and gestation is a period of heightened cardiac vulnerability. Additionally, stress effects can impair a mother’s ability to provide a nurturing environment. Thus, it is crucial to identify and mitigate factors that can enhance maternal outcomes. Atrial natriuretic peptide (ANP), B-type natriuretic peptide (BNP), and troponin I are critical biomarkers of cardiac function, with essential roles in diagnosing and monitoring CVD. ANP and BNP are natriuretic peptides that regulate fluid balance, blood pressure, and cardiac remodeling, while troponin I serves as a marker of myocardial injury. We hypothesized that gestational stress would alter postpartum cardiovascular function and geometry, leading to increased protein expression of cardiac biomarkers. To test this hypothesis, we exposed adult female pregnant and nonpregnant rats to either 10 days of chronic gestational stress or handling. Cardiac function was assessed on postpartum days 14 and 24 using echocardiography. Rats were euthanized 24 hours after the last echocardiography session, and the heart was dissected into left and right atria and ventricles respectively. Tissues were weighed and prepared for protein analysis. Preliminary data showed that stress and parity decreased (increased?) changes in ventricular wall measurements while parity increased ejection fraction in the late postpartum (p=0.047). Parity significantly decreased ANP (p=0.001), Pro-ANP (p=0.026), and BNP (p=0.036) levels in the left atria. These data highlight independent effects of stress and parity on the postpartum heart that affect hemodynamic changes. Future directions will investigate cardiac corin, the enzyme responsible for natriuretic peptide cleavage, to determine whether stress compromises its function.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Yates, Myrtle	Grady, John	Protecting Sponsorship Value from Ambush Marketing in Mega Sport Events: 2026 Winter Olympics and 2025 FIFA Club World Cup View Full Text Abstract Text Mega-sporting events such as the Olympic Games and FIFA World Cup depend heavily on corporate sponsorships as a primary source of revenue. Perceived sponsorship value is threatened by ambush marketing, a strategy where companies attempt to associate their brand with an event in consumers’ minds without paying for official sponsorship rights. As global sporting events continue to grow in scale and media exposure, ambush marketing has become an increasingly significant challenge for organizers and sponsors, especially on social media. This research explores how ambush marketing occurs at major international sporting events, the implications it has for sponsors and event organizers, and the strategies organizers can use to protect sponsorship value. By examining the creative marketing tactics used by non-sponsor brands to gain visibility and engagement during high-profile sporting events, this project identifies key challenges to maintaining sponsor exclusivity. Through qualitative analysis of marketing campaigns, mainly via social media posts, as well as review of existing sport marketing and legal literature, this research contributes to the sport marketing knowledge base and provides a more contemporary understanding of the strategies available to protect sponsorship rights in the global sport industry.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Curry, Anajae	Billings, Deborah Perumal, Nandita	Nourishing Health: Observing the Role of Hormonal Phases and Social Determinants on Nutritional Needs During Reproductive Phases View Full Text Abstract Text Many young women of reproductive age experience the natural hormonal fluctuations of the menstrual cycle. Despite this common experience, limited education surrounding menstrual health has contributed to misunderstandings about how to manage hormonal changes effectively. While quantitative research suggests that nutrition influences the ovarian cycle and hormonal balance, less is known about how young women perceive and implement nutritional practices throughout their menstrual phases. This qualitative study explored the live experiences of women regarding nutrition and hormonal regulation during the menstrual cycle. Semi-structured interviews were conducted with 10 women aged 17 to 23, primarily from South Carolina. Interviews were audio and video recorded, transcribed, and analyzed using thematic analysis to identify common patterns in participants’ understanding and nutritional behaviors across the follicular, ovulatory, luteal, and menstrual phases. Results indicated that approximately 60% of participants perceived nutrition as playing a significant role in their menstrual health, while 30% reported no prior awareness of a connection between dietary intake and hormonal regulation. Participants expressed varying levels of knowledge regarding phase-specific nutritional needs. Overall, findings suggest a gap in menstrual health education and highlight the need for improved nutritional guidance tailored directly to hormonal phases. These results may inform future educational interventions aimed at empowering young women of reproductive age to better understand and support their reproductive health.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
McGregor, Linden	Outten, Caryn Warahena Liyanage Dona, Shashini	Purification and Reconstitution of the S. pombe Iron Repressor Fep1 for Structure/Function Analysis View Full Text Abstract Text Iron homeostasis is necessary to maintain sufficient, non-toxic iron levels in almost all living organisms. Iron plays an essential role in many biochemical pathways, but excess iron can lead to the production of damaging reactive oxygen species. The model yeast S. pombe maintains iron homeostasis via two iron-responsive transcriptional repressors, Php4 and Fep1 (1). Both proteins have close homologues in human fungal pathogens, thus S. pombe provides an effective model for understanding essential iron homeostasis pathways that may be targeted for the development of antifungal compounds. Fep1 is a GATA-type Zn-finger protein that downregulates iron import during iron sufficiency to avoid iron overload (2). Our lab has shown that binding of a [2Fe-2S] cluster regulates the DNA-binding activity of Fep1, and that the Fe-S cluster trafficking proteins Grx4 and Fra2 facilitate removal of the cluster from Fep1 during iron deficiency (3). However, the structure of Fep1 has not been experimentally determined. To produce a protein suitable for structural determination, we generated and purified a truncated version of Fep1 using site-directed mutagenesis and recombinant protein expression and purification. This truncated version is a portion of the DNA-binding domain (amino acids 1-110) that includes zinc finger 1 and the cysteine-rich region hypothesized to bind iron and interact with Grx4. We successfully generated the Fep1(1-110) plasmid and expressed the truncated protein in E. coli. Purification via cell lysis, sonication, and column chromatography yielded a sample with >95% purity, and the circular dichroism spectrum of the sample suggests binding of a [2Fe-2S] cluster, as hypothesized. Semi-enzymatic reconstitution also successfully loaded [2Fe-2S] cluster onto purified Zn-Fep1(1-110). The purified protein will be used for crystallization trials to obtain the 3D structure and visualize the metal-binding sites. Our future studies will focus on measuring the DNA-binding properties of this construct and evaluating its interaction with Grx4-Fra2.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Sturkie, Marion	Hollis, Brian	The Role of the Pheromone cis-Vaccenyl Acetate in Mediating the Rival Effect in Drosophila melanogaster View Full Text Abstract Text Previous research shows that sensory cues influence mating behavior in Drosophila melanogaster, but it remains unclear which cues are necessary to produce the male “rival effect,” in which males adjust mating behaviors such as mating duration when competitors are present (Bretman et al., 2011). To investigate this question, I first exposed males to other males using dividers that allowed visual and olfactory cues while preventing direct interaction. This limited sensory exposure did not produce detectable changes in mating behavior relative to controls, suggesting that these cues alone may not be sufficient to simulate the presence of rivals. To focus directly on a single sensory cue, I next conducted experiments testing the effect of synthetic cis-vaccenyl acetate (cVA), a male-specific pheromone associated with aggregation and courtship behaviors. By exposing males to both low and high concentrations of cVA, I tested whether this pheromone alone could generate the rival effect. If so, pheromone exposure could provide a controlled way to study changes in male mating behavior—such as mating probability, latency, and duration—without confounding factors introduced by the presence of live rivals. This work aims to better understand the role of olfactory cues in mediating mating responses and whether pheromone exposure alone can influence behaviors typically associated with rival males.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Plumer, Michael	Hofseth, Lorne Hebert, James	DIETARY INFLAMMATION AND COGNITIVE DECLINE IN INDIVIDUALS WITH ALZHEIMER’S DISEASE IN SOUTH CAROLINA USING THE DII™ View Full Text Abstract Text Alzheimer’s Disease (AD) is one of the most common causes of senile dementia worldwide, currently affecting over 7 million Americans, a number expected to double by 2050. AD is a multifactorial disease with numerous risk factors, two of which are inflammation and diet. Inflammation is the biological response to stress that is closely tied to oxidative stress (OS). Chronic high levels of inflammation or OC can be detrimental to immune function, linked to accelerated cognitive decline. The diet is a lifestyle factor linked to the modification of inflammation/OS and cognitive impairment in Alzheimer’s Disease patients. Dietary inflammation levels can be measured through the Energy-adjusted Dietary Inflammatory Index (E-DII™). The E-DII™ is an evidence-based score that estimates the inflammatory potential of an individual’s overall diet, based on the types and amounts of foods and nutrients consumed, while adjusting for total energy intake, a common confounding variable. Thus, the objective of this pilot study was to examine whether dietary inflammation is associated with AD-related cognitive decline by evaluating the relationship between Energy-adjusted Dietary Inflammatory Index (E-DII™) scores and longitudinal rates of cognitive decline. A total of 15 pairs of individuals with AD and their caregivers were enrolled in the study. Caregivers completed Food Frequency Questionnaires for the patient, and the patients’ cognitive function was assessed using the Mini-Cog and Mini Mental State Examination at baseline and again at a 6-month follow-up. Linear regression analyses were conducted to determine the relationship between dietary inflammation and cognitive decline. Despite the modest sample size, higher E-DII™ scores were associated with faster cognitive decline over time, with each one-unit increase in DII corresponding to a 0.73-point greater reduction in MMSE score (β = −0.73, p = .010). These findings suggest that a more pro-inflammatory diet may contribute to accelerated cognitive deterioration in individuals with Alzheimer’s Disease.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Kondrikova, Marina Samuel, Lindsey	Smith, Deanna	Molecular and behavioral changes in adult mice with astrocyte-specific Lis1 Knockout View Full Text Abstract Text LIS1 is expressed in both the developing and adult nervous systems and interacts with dynein, a microtubule (MT) motor protein important for mitosis, phagocytosis, cell migration and intracellular transport. Mutations in Lis1 cause lissencephaly, a rare brain malformation characterized by reduced brain folding, cognitive and motor disfunction and shortened lifespan. The Smith lab showed that Lis1 regulates axonal transport in cultured adult neurons, and that induced global knockout (iKO) of Lis1 in adult mice resulted in rapid lethality, demonstrating important post-developmental roles. We have now induced iKO specifically in adult mouse neurons or astrocytes. Depletion in neurons is lethal, and axons showed signs of severe degeneration. On the contrary, mice survive when Lis1 is disrupted in astrocytes but expression of glial fibrillary acidic protein (GFAP), a marker of astrocyte reactivity, is upregulated, indicating that the cells may shift into a “reactive” state. This reactivity can disrupt and alter neural circuit stability, and we have noted evidence for increased anxiety in these mice. We will use behavioral analysis tools such as MoSeq and Blackbox Bio, alongside established behavioral assays like the light-dark and open field tests, to quantify anxiety- and motor-related changes in these mice. Cultured astrocytes from iKO mice show evidence of reduced dynein activity. Because phagocytosis by adult astrocytes contributes to synaptic pruning, we will examine tissues for gain or loss of synapses, particularly in regions of the brain linked to anxiety. Also, because GFAP upregulation is typically caused by axonal pathology we will look for signs of axonal degeneration in fiber tracts in astrocyte-specific Lis1 iKO mice. These studies will correlate Lis1 and dynein-dependent cellular processes in astrocytes with mouse behavior.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Srivastava, Paras	Shimizu, Linda	Crystallization and utility of brominated phenylethynylene bis-urea macrocycles View Full Text Abstract Text Bis-urea macrocycles can spontaneously self-assemble into ordered structures through hydrogen bonding via their urea groups. These structures can be columnar, allowing for their utility as hosts in host-guest systems.1 Reactions between the guests within these hosts can be used to enhance or modify stereospecificity, reaction rates, and other physical properties.2 Previously, photodimerization reactions between coumarins and chromones have been studied in host systems of phenylethynylene bis-urea macrocycle 1, resulting in the improved specificity and yield of the photodimerization products.3,4 Herein, we apply a dynamic covalent chemistry (DCC) strategy to synthesize macrocycle 1 and its derivative macrocycle 2 containing exterior bromides, improving the yield of the cyclization reaction from 10% up to 29%. We are screening crystallization conditions to attempt to obtain large crystals of 1 and 2 for structure elucidation by single crystal X-ray diffraction. In addition, co-crystal formation is being screened using equimolar mixtures of macrocycles 1 and 2 as well as employing additives that can fit in the channels. Once crystals are obtained, these hosts with their accessible columnar channels will be investigated as nanoreactors. This study will contribute to the design of functional materials for the synthesis of useful photoproducts that are challenging to synthesize.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Remaili, Soraya	Meyer-Gutbrod, Erin Kreuser, Abigail	Lessons from Real-Time and Archival Acoustic Detections of North Atlantic Right Whales in the Southeast US across Three Types of Platforms View Full Text Abstract Text The critically endangered North Atlantic right whale (NARW) migrates seasonally along the US East coast to their winter calving grounds in the Southeast US. In the shallow waters off the coasts of South Carolina, Georgia, and Florida, NARWs nurse, rest, and socialize near the surface, exposing whales and calves to a high risk of ship strike. In NARW’s northern foraging grounds, real-time passive acoustic monitoring (PAM) using gliders and buoys is being used to inform monitoring efforts and communicate detections with vessel captains and managers to reduce risk of vessel strikes. In the Southeast US, glider-based PAM may also be a useful monitoring tool for providing 24/7 coverage. However, the unique shallow environment creates uncertainty in the detectability of NARWs in the region. To better inform the deployment of real-time instruments in this region, we analyzed acoustic data from three different platform types. Three bottom-mounted, archival hydrophones were deployed at increasing depths (15.9m, 19.5m, 22m) and distances off the coast of Savannah, Georgia, from January-May 2023-2026. Real-time PAM buoys were deployed off the coasts of Norfolk, Virginia and Savannah, Georgia at the beginning of the 2023 calving season. A real-time PAM-equipped Slocum Glider was deployed over 6 approximately 1-month long missions in January-March from 2023-2026. The Norfolk buoy triggered 17 acoustically-detected Slow Zones over this period, and 2 acoustic right whale detections on the Savannah buoy in January 2026 triggered the first ever acoustic Slow Zone in the South Atlantic Bight. The NOAA-issued Slow Zones provide critical real-time information to mariners about right whale presence and vessel strike risk, requesting reductions in vessel speeds to <10 knots. These detections and associated Slow Zone notices demonstrate potential for an acoustic real-time monitoring program that would complement existing aerial monitoring efforts in the Southeast US.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Hiers, Eli	Miller, Sarah	Structural Misalignment Through Perception of Local Opportunity; Allendale, SC View Full Text Abstract Text My research examines the economic barriers and their impact on career decision-making in Allendale County, SC. My results show that sustained disadvantages negatively affect community perceptions of local opportunities. Using 2019-2023 Census data, I examined barriers such as poverty, income level, job security, educational level, and access to computers, cars, and internet access for Allendale County and the surrounding counties of Bamberg, Barnwell, Colleton, and Hampton to contextualize the area. Next, I reviewed how these barriers manifest in K-12 education and intensify until graduation. The third phase of this project is to identify the misalignment between community perception and reality. The combination of IPEDS data and industry composition Census data is used as a benchmark for the reality of local opportunity in Allendale County, while interviews with local success stories and staff testimonies are used as a benchmark for community perception. During this study, I expected to find a direct link between how people in the community saw things and how many students from Allendale Fairfax High School signed up for classes at USC Salkehatchie. This was not the case. Instead, I found a structural misalignment between community perception and industry composition, which provides a basis for subsequent research and applications regarding the positive recognition of opportunities within the community perception framework.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Craft, Nicole	Shimizu, Linda	Modulating the Assembly of Supramolecular Polymers of Bis-Urea Macrocycles View Full Text Abstract Text Bis-Urea Macrocycles demonstrate precise natural self-assembly through noncovalent hydrogen-bonding interactions. These interactions form nanotube-like fibrous structures. The goal of this study was to investigate whether this natural polymerization could be controlled in m-terphenyl bis-urea macrocycles (1), to produce assemblies with defined size and structural selectivity. To achieve this control, two strategies were investigated: supramolecular chain-capping and template-assisted polymerization. The first strategy regulates nanotube length by introducing capping agents that bind to the ends of growing assemblies of (1), preventing further elongation entirely. The second strategy develops structural selectivity by incorporating a molecular template, designed to stabilize specific nanotube structures and sizes during formation. The effectiveness of both approaches was evaluated using UV–Vis spectroscopy, which monitors the assembly of (1) through size- and shape-dependent absorbance changes. To further investigate the assembly mechanism, concentration- and time-dependent cooling experiments were performed. By gradually cooling the solutions and measuring absorbance at multiple wavelengths, the formation process was able to be examined in detail. The resulting data were then used to generate a spectrum plotting aggregate fraction versus temperature to mathematically confirm structure formation. These results indicate that the supramolecular chain-capping method is the more effective method for controlling polymer growth of (1). Effective chain stoppers required hydrogen-bond acceptor strengths (β values) exceeding 8.3, comparable to the β value of the urea groups within macrocycle (1). Phosphate-derivative chain stoppers, particularly phosphonate diesters (β = 8.9), demonstrated the greatest ability to limit this elongation. Overall, this work demonstrates that supramolecular polymerization of (1) can be controlled in solution, providing a practical method for regulating macrocyclic elongation.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Kantor, Molly	Weik, Terrance Wright, Parrish	Alea Iacta Est, analyzing cultural transfer through Ancient Roman dice View Full Text Abstract Text Dice have been used for thousands of years, both as gaming tools and as divination devices- objects that help people communicate with the gods through chance. Roman archaeologists typically categorize dice only as gaming objects and treat them as small finds. This research investigates Ancient Roman dice as divinatory devices and how their features can show processes of cultural transmission by focusing on materials dating from the fifth century BCE to the fifth century CE from sites in Italy (Gabii, Pompeii), England (Londinium), and Egypt (Naukratis). The approach used in this research is a comparative typological and methodological study, viewed through the lens of entanglement. Changes in the die material, form, pip style, and configuration demonstrate the intentionality of die-making and therefore help identify cultural markers that indicate whether a die had the potential to serve as a divination device. Intentional symbolic meaning exists in Ancient Roman dice, and these meanings evolved through cultural transmission across the Roman Empire. The findings show that Ancient Roman dice should not be dismissed as solely gaming objects but as objects that could be used in ritual practices, thereby providing further insight into the everyday lives of the Ancient Romans and the groups they came into contact with.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Alarcon, Selene	Gonzalez, Veronica	California vs South Carolina: Political Differences Within Hispanic Communities View Full Text Abstract Text This study examines political differences within Hispanic communities in two distinct regions: California and South Carolina. While Hispanic populations are often treated as politically uniform, this project starts from the assumption that political attitudes are shaped by local context, including state policy environments, community demographics, migration histories, and everyday experiences with institutions. Using a mixed-methods design, the research combines survey data with semi-structured interviews to identify both broad patterns and deeper explanations for how participants understand contemporary politics. The analysis focuses especially on perceptions of the current political climate and immigration-related issues, including how respondents interpret policy debates, evaluate political parties and leaders, and describe the impacts of political decisions on their families and communities. Comparing two states with very different political cultures offers a way to examine how place shapes political attitudes within the same broad ethnic category. Rather than assuming a single “Hispanic perspective,” the study highlights variation across regions and emphasizes the importance of community-level and state-level context in shaping political beliefs. Findings contribute to discussions of political behavior, identity, and representation by showing how geographic setting can influence the issues that feel most urgent, the language people use to describe them, and the forms of political engagement they view as possible or effective.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Deutsch, Shannon Patel, Trishna	Wippold, Guillermo Garcia, Kaylyn	Bridging Research and Practice: The Role of Undergraduate Research Experience in Shaping Future Nurses View Full Text Abstract Text As nursing students at USC, we believe research experience is a vital component of the undergraduate nursing experience. Gaining research experience strengthens the clinical competencies essential to professional nursing practice and reinforces the principles of evidence-based practice (EBP), which integrates current research with clinical expertise to deliver high-quality, patient-centered care. Research shows that applied experiences with EBPs significantly improve undergraduate nursing students’ critical thinking, evidence appraisal, and clinical decision-making skills (Jeong et al., 2024). Furthermore, students involved in EBP projects report increased confidence in analyzing and applying research findings to real-world settings (Baixinho et al., 2022). Through our involvement as research assistants (RAs) in the Community Health Interventions and Resilience Promotion (CHIRP) Lab, we have gained experience translating research into practice through community-based participatory research (CBPR). CBPR is an approach to research that involves communities as equal partners in the research process to help bridge the research to practice gap. The CHIRP lab utilizes a CBPR approach to specifically address disparate health outcomes of Black Americans relative to other racial/ethnic groups. Being RAs in the CHIRP lab has thus deepened our understanding of the impacts of racism, discrimination, and medical mistrust on health outcomes among marginalized communities and how research can be leveraged by nurses to select/tailor EBPs, promote health, and advocate for health equity. Our experience as RAs in the CHIRP lab have also emphasized the importance of trust-building and culturally responsivity when working with marginalized communities - a critical component of our practice as future nurses. Ultimately, attendees of this presentation will learn that undergraduate research experience helps bridge the research to practice gap, shaping reflective, culturally responsive, and forward-thinking nurses prepared to meet the healthcare needs of diverse communities.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Childs, Alexandra	Wessinger, Carolyn	Testing biochemical hypotheses concerning a purple-white polymorphism in Penstemon whippleanus View Full Text Abstract Text Penstemon whippleanus exhibits a balanced within-population polymorphism in which individuals have either purple or white flowers. These polymorphic populations are found throughout the geographic range of P. whippleanus, suggesting that natural selection is maintaining variation via balancing selection. The gene responsible for this polymorphism is an R2R3-MYB transcription factor. This gene regulates the expression of the flavonoid pathway, which is responsible for production of colorful anthocyanin pigments and UV-protective flavonols found in flowers and leaves. Prior work suggests the purple allele is dominant, but remains untested. PCR-based genotyping allows us to test this dominance hypothesis by measuring flavonoids (anthocyanins and flavonols) and observing if genotype explains flavonoid concentration differences. We collected leaves and flowers for fifty individuals from a population in Colorado. Flavonoids were extracted through acid-methanol extraction and measured via UV-vis spectroscopy. We investigated genotype-based differences in flavonoid concentrations in flowers and leaves. Results showed all genotypes had differences in anthocyanin concentration in flowers (p< 0.0001), but not flavonols. Differences between purple-flowered genotypes were smaller (p=0.0084) than the differences between purple- and white-flowered genotypes (p<0.0001), suggesting partial dominance of the purple allele. Pleotropic genes (genes affecting many traits), are more likely to be selected against. Hence, theory predicts that the genetic basis of balance polymorphisms is unlikely to be pleiotropic. We tested this hypothesis by asking if the phenotypic difference in flowers is also present in leaves. Results showed no significant group differences between MYB genotype and production of anthocyanins or flavonols in leaves, suggesting the MYB gene is not pleiotropic. This supports the hypothesis that genes underlying balanced polymorphisms are likely to have few phenotypic effects, demonstrated by variation at the MYB only affecting flower anthocyanins and not floral flavonols or leaf flavonoids.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Mehta, Ariya	LoPresti, Eric Jaeger, Sierra	Dynamic between Betalain Pigmentation and Reproductive Success in Abronia fragrans View Full Text Abstract Text Varied pigmentation within a species can influence selective environmental factors. Specifically analyzed in the Abronia fragrans, exhibition of differing betalain pigmentation within the sole population geographically located in the same area is potent. Betalain is a nitrogen-containing pigment that aids in deterring herbivory and protects against abiotic stress. High betalain concentrated plants are associated with having a divergent phenotype of a pink coloration. These pink colored A.fragans have been discovered to be present in wet, hot climates as white colored A.fragans are found in cooler climates. Climate is not the only differing factor we see between the two varied betalain A.fragrans, the diurnal and nocturnal pollination patterns is another primary factor we believe pigment variations have influenced and what we plan to evaluate. We hypothesized that the white colored A.fragans will have greater nocturnal visitation during the night due to the moonlight reflecting onto the flower, making it visible for pollinators; the pink colored A.fragrans will have more diurnal pollinators during the day due to the bright color attracting pollinators. To test this, we quantified seed sets separately during day and night periods for both the white and pink A.fragrans. We have not derived our results yet; therefore, there are no conclusions or trends we can infer from our present data.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Washer, Lemon	Jilling, Andi	Linking Soil Health to Soil faunal Diversity Across South Carolina Farms View Full Text Abstract Text Soil health is defined by both the current and future capacity of the soil to function as a vital ecosystem that sustains all matter of life. Within agriculture, a healthy soil is productive (i.e., high-yielding) while also supporting biodiversity and microbial activity. Soil fauna are an overlooked aspect of soil health, despite their prominence in microbial food webs, nutrient cycles, decomposition, bioturbation, aggregate formation, and soil organic matter turnover. Common micro and meso-fauna in agricultural systems include nematodes and arthropods, which will be the focal point of this study. We will evaluate fauna abundance and diversity in soils under perennial or annual crop management as these systems are expected to differ significantly in soil organic matter and physical structure. Perennial systems are minimally disturbed, retain living roots and support more diverse plant communities and micro-habitats – all features that are expected to facilitate soil faunal activity. We have collected soils from three farms in South Carolina and will use an established Berlese-Tullgren funnel method to extract and count the abundance of nematodes and arthropods. We hypothesize that the increase in soil organic matter content will also lead to increased diversity and abundance of soil fauna.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
McLeod, Emily Page, Claire	Ferguson, Shea Dawes, Molly	The Role of Preparation in Developing Preservice Teachers’ Self-Efficacy for Classroom Management View Full Text Abstract Text Classroom management has important implications for both students (e.g., academic success) and teachers (e.g., teacher well-being) (Duan et al., 2024). However, new teachers often report difficulty managing behaviors in the classroom (Zhang et al., 2025). Prior research (e.g., Lazarides et al., 2020) suggests that teachers' classroom management practices are influenced by their self-efficacy (i.e., confidence). Notably, teachers' self-efficacy in classroom management is often formed early during teacher preparation (Dicke et al., 2014). This is consistent with Social Cognitive Theory (Bandura, 2001), which highlights the importance of mastery and vicarious experiences in developing self-efficacy. While teacher self-efficacy has been widely studied, less is known about how specific types of preparation during teacher training relate to self-efficacy in classroom management. Therefore, the purpose of the current study was to examine preservice teachers’ preparation in aggressive behaviors, proactive strategies for managing behavior, and their self-efficacy for classroom management. We hypothesized that teachers who reported higher preparation would also report higher self-efficacy. Participants included graduating preservice teachers from preparation programs across the United States (N = 241, 96% female, 82% white). Participants completed an online survey, which included measures of preparation in managing aggressive behaviors and proactive strategies for managing behaviors (O’Neill & Stephenson, 2012), as well as self-efficacy for classroom management (Tschannen-Moran & Hoy, 2001). In terms of findings, correlational analyses demonstrated a positive relationship between preparation in aggressive behavior and self-efficacy for classroom management, as well as between preparation in preventative strategies and self-efficacy for classroom management. A multiple linear regression predicting self-efficacy for classroom management revealed preparation in preventative strategies as a statistically significant predictor. Consistent with prior research (Ma et al., 2025), findings from this study emphasize the importance of receiving behavior management coursework in teacher education programs to strengthen preservice teachers' self-efficacy.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Mai, Nora	Ferguson, Shea Dawes, Molly	Can Children Control Their Emotions? Teachers' Beliefs About Emotion Control, Emotion Display, and Emotion Socialization Responses View Full Text Abstract Text Teachers’ responses to children’s emotions have implications for children’s social and emotional development (Denham & Bassett, 2019). This can be understood through Emotion Socialization Theory (Eisenberg et al., 1998), which states that children learn about emotions, including how they should be expressed and managed, through interactions with others, as well as through observing others. Teachers, therefore, have an important role as emotion socializers. Prior research suggests that teachers’ beliefs about emotions likely relate to how they respond to children’s emotions (Ornaghi et al., 2020). However, less research has examined how multiple types of emotion related beliefs relate to teachers’ emotion socialization responses. Therefore, the purpose of the current study was to examine teachers’ beliefs about children’s ability to control their emotions (i.e., emotion control beliefs) and their beliefs about the social consequences of displaying negative emotions (i.e., emotion display beliefs) in relation to their emotion socialization responses (i.e., supportive and unsupportive). We hypothesized that higher emotion control beliefs (i.e., belief that children can control their emotions) and higher emotion display beliefs (i.e., beliefs that displaying negative emotions will result in social consequences) would be negatively related to supportive responses and positively related to unsupportive responses. Lastly, we hypothesized that together, these beliefs would predict responses. First-year teachers (N = 140) across the United States completed an online survey on their beliefs about emotions and intended responses to children’s emotions. Correlation analyses will be conducted to examine the relationships between emotion control beliefs, emotion display beliefs, supportive responses, and unsupportive responses. Additionally, a multiple linear regression will be conducted to examine the role of beliefs in predicting responses. Findings from this study have the potential to inform the development of interventions by identifying how two distinct beliefs shape teachers’ responses to children’s emotions.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Franks, Hannah	Green, Jessica	Motivation on a Budget: How Reward Type and Sustained Attention Improve Auditory Spatial Processing View Full Text Abstract Text In an increasingly distracting world, our capacity to extract relevant information from our environment is crucial. One aspect of our ability to accurately pay attention to our surroundings is sound localization; therefore, investigating potential mechanisms to enhance sound localization remains a valuable area of study. Existing research suggests that using rewards to elicit motivation for attentional tasks may yield invaluable insight. Furthermore, the potential of non-monetary incentives to elicit effects comparable to monetary incentives offers an exciting opportunity for designing cost-effective experiments that reliably motivate behavior change. However, whether monetary rewards are necessary to elicit improvement in behavioral change remains unclear. Additionally, whether reward in general, regardless of type, is an effective method for motivating auditory spatial performance has yet to be explored. The current study investigated the effect of reward on performance in sound source localization (SSL), specifically examining whether reward type and frequency of attentional shifts significantly influenced performance. Through three experiments, we implemented a two-hemifield SSL task in a dark, sound-attenuated chamber, and varied reward type (monetary versus gamified points) and attentional sustainability (long-term versus short-term) across 106 university students. Participants were instructed to localize a beep tone from a random location within either a rewarded or unrewarded hemifield. Experiment 1 employed monetary incentives ($0.05), while Experiments 2A and 2B employed non-monetary rewards (5 points). Reward value was alternated across hemifields once at the halfway mark (Experiments 1 and 2A) or more frequently after each block (Experiment 2B). Across all experiments, reward-associated hemifields, regardless of reward type, elicited improved accuracy and precision. Experiments 1 and 2B revealed significantly slower reaction times, suggesting participants responded cautiously to maximize reward. Overall, these findings suggest that reward improves SSL performance, and that non-monetary rewards can produce effects comparable to monetary incentives when paired with frequent attentional shifts.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Soda, Sean Nomm, Kaeden	Berry, Hala Yongue, Zane	Integrating Blockchain Technology into RFID Middleware for Intrusion Detection View Full Text Abstract Text With the increased development of RFID technology, it has seen widespread usage within supply chain management within the commercial sector. This increased adoption of RFID has led to more possible attack vectors that can disrupt the systems that rely on RFID. Most research has put a focus on upholding the security of the RFID tags themselves but have overlooked the middleware that stores such events. This oversight has left the middleware vulnerable to attack vectors such as SQL injections via the tags to manipulate the data stored. The rise of blockchain integration has allowed the ability to create an immutable digital ledger that maintains the integrity of the stored data. The purpose of this research is to integrate blockchain technology with RFID based systems. To further verify the integrity of both the blockchain and database a LLM will be integrated. The LLM will monitor and analyze both systems for discrepancies to maintain data integrity. After completion, we successfully integrated a script that was able to conduct an automated audit on the blockchain and database to verify if the batch was altered. From there the LLM was able to analyze the mismatched batch and correctly determine where the discrepancy was located. This proves that integrating blockchain technology with the assistance of an LLM can be used for intrusion detection in RFID based middleware for supply chain management systems.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Siciliano, Sophia	Twiss, Jeff Matoo, Samaneh	REG3A to KHSRP Signaling Restricts CNS Axon Regeneration View Full Text Abstract Text Unlike in the PNS, neurons of the CNS have a limited ability to regenerate, restricting functional recovery after injury. PNS regeneration is supported in part by localized mRNA translation that enables local synthesis of growth-promoting proteins. Evidence shows that the CNS axons also contain mRNAs and synthesize proteins. We previously reported that in the PNS, RNA-binding protein KHSRP is locally translated in injured axons, where regeneration decreases by promoting mRNA decay. Although KHSRP translation is initially triggered by an injury-induced axoplasmic influx of calcium, KHSRP levels remain elevated after calcium levels normalize. Suggesting a mechanism exists to sustain axonal KHSRP synthesis. We have shown that REG3A protein increases axoplasmic calcium and recombinant REG3A (recREG3A), which increases axonal KHSRP, inhibiting axon growth in DRG cultures. Depletion of endogenous REG3A decreases axoplasmic calcium, increases axon growth, and nerve regeneration in the PNS. Using optic nerve (ON) crush for the CNS we find upregulation of Reg3a mRNA increases REG3A and KHSRP proteins in the injured ON. To test whether REG3A decreases CNS regeneration, we injected AAV2-shReg3a-BFP and shCntl-BFP intravitreally to target retinal ganglion cells (RGCs). Depletion of Reg3a increases axon regeneration after ON crush and increases RGC survival. CNS growth inhibitory substrates increase axoplasmic calcium and KHSRP levels. Depletion of REG3A allows axonal growth and prevents the increase in KHSRP when cultured on CNS growth-inhibitory substrates in cortical and DRG neurons. This shows that REG3A–KHSRP signaling limits CNS axon regeneration and likely enhances neuronal sensitivity to growth-inhibitory substrates. Sophia Siciliano1, Samaneh Matoo1, Jinyoung Lee1, Courtney N. Buchanan1, Lauren S. Vaughn1, Jeffery L. Twiss1,2 1.Department of Biological Sciences, University of South Carolina, Columbia SC 29208 USA 2.Carolina Autism and Neurodevelopment Research Center, University of South Carolina, Columbia SC 29208 USA	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Turner, Bailey	O'Reilly, Christian	A Systematic Review of Machine Learning Techniques for Biosignal Analysis View Full Text Abstract Text Biosignals such as electroencephalography (EEG), electromyography (EMG), and electrocardiography (ECG) are integral tools in neuroscience and biomedical research. In particular, biosignals such as electrodermal activity (EDA), respiration, and heart rate variability (HRV) derived from ECG are often used to analyze the autonomic nervous system (ANS), which regulates involuntary functions essential for survival. Understanding the ANS is important because it reflects the body's ability to maintain homeostasis and adapt to physiological and emotional demands. However, the fragmentation of literature across disciplines, biosignal types, and methodological frameworks has caused confusion among researchers. This project aims to write a systematic review synthesizing state-of-the-art machine learning (ML) methods from the last 5 years to clarify which approaches are the most effective for biosignal analysis. This project follows PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. An integrated search was conducted in PubMed, PsycINFO, Web of Science, and Scopus, using keywords and MeSH terms such as machine learning, signal processing, biosignals, and autonomic nervous system. The search resulted in 1,108 unique studies after duplication removal and screening through Covidence left 414 papers for full-text review and 83 for final extraction. Evaluation variables include F-1 scores, accuracy, specificity, sensitivity measures for classification studies, and R2 for regression studies. Anticipated results include a comparative evaluation of which machine learning techniques were most effective across different kinds of autonomic biosignals, the identification of research gaps, and directions for future studies. This project ultimately aims to identify the best ML techniques for biosignal analysis to help researchers more easily identify appropriate techniques for their work and make computational methods more accessible to all research fields involving biosignal analysis.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Sawhney, Sifat	Shinkareva, Svetlana Oh, Sewon	The Impact of Emotional Authenticity on Facial Fixation Patterns: An Eye-Tracking Study View Full Text Abstract Text Emotional authenticity reflects the alignment between one’s expressed emotions and the emotions felt internally. Understanding how individuals discern between genuine and disingenuous emotions is critical to effective social interactions. In everyday life, people hide their true emotions through subtle changes in facial expressions, making authenticity difficult to detect. We investigated how visual attention is distributed across facial regions when individuals process authentic versus inauthentic happy and sad emotional expressions using eye-tracking technology. Prior research suggests people look at the eyebrows, eyes, and mouth while trying to discern emotional expressions. This study focuses on these regions in happy and sad expressions, two affective states with distinguishable facial cues. We hypothesized that authentic happy expressions would elicit greater fixation in the lower facial region whereas inauthentic happy expressions would result in increased fixation towards the upper facial region. It was also hypothesized that authentic sad expressions would produce a more balanced fixation distribution where inauthentic sad expressions would drive increased fixation in the upper facial region. To test these hypotheses, 87 female participants viewed facial expressions across four conditions: authentic happy, inauthentic happy, authentic sad, and inauthentic sad. The experiment consisted of two blocks in which participants categorized whether each facial expression was authentic or inauthentic in one block and happy or sad in another. Each stimulus was presented for 2–5 seconds, after which participants made their judgement and rated intensity of their choice on a 4-point scale. Using silent videos expressing facial emotions, participants made judgements based solely on visual cues. Fixation count and duration were analyzed comparing upper and lower facial regions as a function of authenticity separated by emotion using repeated measures ANOVAs. By examining fixation patterns across facial regions, this study aims to deepen understanding of how emotional authenticity and valance guide visual attention during emotion perception.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Lutz, Hanna	Lee, Junsoo	Finite Time High Precision Control of Robotic Arm Manipulator View Full Text Abstract Text In dynamical systems theory, asymptotic and exponential control aim to drive system trajectories to a desired state over an infinite time horizon. However, in high-precision applications, control objectives must be achieved within a finite time window with minimal error. Finite-time control (FTC) ensures convergence to the desired state within a predefined time frame while maintaining stability and minimizing error. While rigorous analysis of finite-time control using sliding mode controllers and Lyapunov theory has been extensively studied, a significant gap remains in bridging continuous-time and discrete-time finite-time control. When the FTC framework is applied to discrete-time systems—where practical controllers are designed—some of its benefits are lost due to discrepancies between continuous-time and discrete-time dynamics. Recent efforts, including implicit discretization methods for FTC, have been proposed to address this gap. The objective of this project is to develop an implicit FTC framework for precision robotics applications. The focus of this research is on bridging the gap between continuous-time and discrete-time systems, where the finite-time property is often lost in the discrete domain. Specifically, the project evaluates the effectiveness of implicit FTC methods in reducing the chattering effect and improving convergence bounds, leading to minimal error. Validations are being conducted through simulations for robotic arm control. Additionally, a robotic arm testbed is being developed to further test and demonstrate the proposed methods in a real-world setting.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Campagna, Collan	Osbaldiston, Richard	Stress and sleep paralysis: A literature review using new AI-based tools View Full Text Abstract Text Roughly 25% of students experience sleep paralysis. To what extent is stress related to sleep paralysis? To answer this question, we used six different literature search tools, including two traditional tools (PsycInfo and Google Scholar) and four new AI-based tools (Semantic Scholar, Consensus, Primo Research Assistant, and Elicit). We evaluated the tools to determine which were most efficient at finding relevant studies. Our answer to the research question is that stress is only minimally correlated with sleep paralysis.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Batson, Emma	LoPresti, Eric	Patterns of Tympanal Ear Mite Parasitism in Noctuid Moths: Evidence for Sex-Biased Infestation View Full Text Abstract Text My thesis investigates host-parasite dynamics between noctuid moths and their highly specialized parasitic tympanal ear mites (Dicrocheles phalaenodectes and D. scedastes). These mites live and reproduce totally within the auditory organs of their host moths, a rare example of highly specialized organ-specific parasitism. Despite decades of foundational work by A.E. Treat documenting mite behavior and host specificity, many of the drivers of variation in infestation among individual moths remain unknown. My project examines patterns of infestation prevalence in noctuid moth specimens, with a particular focus on whether infestation is sex-biased. It is suspected that mites disperse via flowers visited by feeding moths; differences in nectar-feeding behavior between males and females may influence their risk of exposure and rate of infestation. Understanding and predicting these patterns is critical because infestation of the tympanal organ may impair hearing and therefore predator detection. This potentially alters host survival, reproduction, and a cascade of ecological interactions. By quantifying infestation patterns and exploring drivers of intraspecific variation in prevalence, this study contributes foundational ecological insight to a uniquely specialized parasite system.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Kapoor, Shriya	Merchant, Anwar	Assessing Nutritional Needs and Food Access Among Uninsured Free-Clinic Patients in Columbia, South Carolina View Full Text Abstract Text Chronic diseases such as diabetes, hypertension, and obesity remain among the most prevalent and preventable health conditions in the United States. Nutrition plays a critical role in preventing and managing these conditions, yet many individuals face barriers to maintaining healthy dietary habits. These challenges are particularly pronounced among uninsured adults, who often rely on free and reduced-cost clinics for healthcare services. South Carolina experiences some of the highest rates of food insecurity and chronic disease in the nation, yet limited research has examined the nutrition-related needs of uninsured adults within this region. This study explored the nutritional needs, barriers, and interests of uninsured adults receiving care at free and reduced-cost clinics in Columbia, South Carolina. An anonymous survey-based needs assessment was conducted among adult patients across multiple free clinic sites in Columbia. Data were collected in person over a two-month period. The survey gathered information on demographics, chronic illness history, food access and food insecurity, dietary habits, nutrition literacy, and interest in potential nutrition-related interventions. By identifying common barriers to healthy eating and understanding patient preferences for nutrition support, this study aimed to provide a foundation for community-centered nutrition initiatives within clinic settings. The findings inform practical, low-cost strategies, such as culturally relevant nutrition education materials, cooking classes, and clinic-based nutrition programs designed to support long-term health among underserved populations.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)
Spina, Andersen	Lee, Junsoo	Will add later View Full Text Abstract Text Small yet capable UAVs have become increasingly vital in both civil and military applications. The Russo-Ukrainian War exemplifies this trend, with both sides deploying large numbers of small UAVs for reconnaissance, surveillance, and strikes. This strategy enables rapid, low-cost deployment, replacing traditional high-cost aerial assets. However, a significant limitation of these drones is their restricted range and endurance. A portable launcher capable of deploying UAVs from any location could greatly extend their operational range and endurance by conserving the energy required for takeoff, which accounts for a substantial portion of power consumption. Additionally, such a system would enable fast and flexible launches, enhancing UAV effectiveness and adaptability, such as allowing completely vertical launches in crowded environments such as forests and urban areas. Recognizing these advantages, several UAV launcher systems have been developed for military applications. The AeroVironment Switchblade 300 Block 20, for example, utilizes a compact 7.2 lb (3.27 kg) launcher with a two-minute setup time and provides approximately 20 minutes of endurance. However, these systems rely on complex mechanisms, such as miniature rocket boosters or compressed gas propulsion, leading to high costs—estimated $53,000 for the AeroVironment Switchblade 300 Block 20, making them impossible for diverse applications other than military use. This project aims to develop a human-mounted fixed-wing UAV launcher with a simple, cost-effective design. We have created concept designs and are in the process of finalizing a hardware testbed for a launcher platform utilizing a flywheel-based propulsion system to achieve affordable, rapid, and efficient UAV deployment. This launch platform will be powered by a lithium polymer battery connected to brushless motors driving compliant flywheels along with high torque servo motors driving the push flap.	9:30-11:00 a.m. Exhibit Hall (CMCC lower level)