The research interests of these faculty encompass all areas of biochemistry, including cell and molecular biology, enzymology, spectroscopy, protein crystallography, and bio-inorganic chemistry.
"The Johnson lab seeks to transform our understanding of disease using structural, biochemical, and biological techniques. We complement biophysical and theoretical approaches, such as x-ray crystallography, molecular dynamics simulations, molecular modeling, and general protein chemistry techniques, with disease modeling techniques in mammalian cell culture and genetically engineered mice."
"Our research is focused on mining microbial genomes to discover drug leads, biosynthetic pathways, and new enzyme biocatalysts. We employ an interdisciplinary approach combining organic chemistry, natural products chemistry, biochemical analysis, metabolomics, genetic engineering, and synthetic biology."
"We study cell signaling of small G-proteins (Ras, Rho, Arf, Rab and others) in human diseases by using chemical biology, biochemistry, computational biology, and mouse model genetics approaches. We are developing neurotherapeutics for small G-proteins with such tools as Schrödinger-based in silico simulation, surface plasmon resonance, and cell-based assays at high content and throughput levels."
“We are interested in understanding how cells regulate the essential metal iron and control thiol-disulfide balance using yeast as a model system. We employ a multidisciplinary approach that includes protein biochemistry, biophysical spectroscopy, molecular genetics, and cell biology."
"We study the homeostasis and metabolism of essential metals like copper, iron and zinc, with the goals of disrupting metal metabolism in bacteria during infection and correcting defects in human metal metabolism that lead to disease."
"We are developing molecular tools to study and direct the function of immune pathways. These tools include peptides, proteins, and small molecules that we envision will enable immunotherapies for treating cancer and pathogenic diseases."
"We use state-of-the-art single-molecule spectroscopic techniques to resolve the conformational dynamics of complicated biomolecules."
"The overall research objective of Dr. Qian Wang's laboratory focuses on using chemical biology tools to probe intracellular activities and the development of hierarchically-structured nanomaterials to study the cooperative response of cells to extracellular matrixes."